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  1. 31041
    “…The aim of the present study was to investigate the efficacy and side-effects of preventive treatment with pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) on concurrent chemoradiotherapy-induced grade IV neutropenia and to provide a rational basis for its clinical application. A total of 114 patients with concurrent chemoradiotherapy-induced grade IV neutropenia were enrolled. …”
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    Clinical observation of the therapeutic effects of pegylated recombinant human granulocyte colony-stimulating factor in patients with concurrent chemoradiotherapy-induced grade IV neutropenia
  2. 31042
    “…Taken together, this underscores the need for BRCA1-IRIS-specific therapy and strongly suggests that BRCA1-IRIS and/or signaling loops activated by it could be rational therapeutic targets for advanced TNBCs.…”
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    BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers
  3. 31043
    “…INTRODUCTION: The development of simple clinical tools to identify children at risk of death would enable rapid and rational implementation of lifesaving measures to reduce childhood mortality globally. …”
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    Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness
  4. 31044
    “…The high frequency of mutation carriers rationalizes genetic testing of ovarian cancer patients in this demographically defined population. …”
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    A targeted analysis identifies a high frequency of BRCA1 and BRCA2 mutation carriers in women with ovarian cancer from a founder population
  5. 31045
    “…The slope of the delivered volume calibration was 0.93 suggesting a systematic volume-dependent bias, which can be rationalized as an effect of suspension flow in capillaries. …”
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    Measurement of Microsphere Concentration Using a Flow Cytometer with Volumetric Sample Delivery
  6. 31046
    “…Therefore, well understanding the agronomic traits and describing germplasms would help to overcome these constraints, and morphological evaluation of tall fescue germplasm is the key component in selecting rational parents for hybridization breeding. However, describing the morphological traits of tall fescue germplasm is costly and time-consuming. …”
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    Association Analysis of Simple Sequence Repeat (SSR) Markers with Agronomic Traits in Tall Fescue (Festuca arundinacea Schreb.)
  7. 31047
    “…This information could warn the hospital to reconsider resetting prices of these tests profitability ration less than 1. The revenue collected could help to build capacity, upscale quality, and sustainable service delivery.…”
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    The revenue generated from clinical chemistry and hematology laboratory services as determined using activity-based costing (ABC) model
  8. 31048
    “…Moreover, recent findings have not only increased our understanding of the molecular basis of chemotherapy resistance but have also helped identify molecular subsets of DLBCL and rational targets for drug interventions that may allow for subtype/subset-specific molecularly targeted precision medicine and personalized combinations to both prevent and treat relapsed/refractory DLBCL. …”
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    Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
  9. 31049
    “…So, LdUMSBP may be an attractive target for rational drug designing and LdU(−/+) parasites could be considered as a live attenuated vaccine candidate against visceral leishmaniasis. …”
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    Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b
  10. 31050
    “…The study was conducted in order to develop a rational strategy to control mosquito populations and prevent the potential human exposure to mosquito-transmitted pathogens. …”
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    Assessment of productivity of Culex spp. larvae (Diptera: Culicidae) in urban storm water catch basin system in Wrocław (SW Poland)
  11. 31051
    “…Antivenom (AV), the rational and most effective treatment modality, is either unaffordable and/or unavailable in many affected countries. …”
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    A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia
  12. 31052
    “…The post-genomic era offers new opportunities for an expedited search using rational vaccine design and prioritization of key B-cell epitopes involved in natural acquired immunity. …”
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    An evolutionary approach to identify potentially protective B cell epitopes involved in naturally acquired immunity to malaria and the role of EBA-175 in protection amongst denizens of Bolifamba, Cameroon
  13. 31053
    “…The ever-increasing demand for natural products and biotechnology derived from bees and ultra-modernization of various analytical devices has facilitated the rational and planned development of biotechnology products with a focus on human health to treat chronic and neglected diseases. …”
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    Polymeric Nanoparticles of Brazilian Red Propolis Extract: Preparation, Characterization, Antioxidant and Leishmanicidal Activity
  14. 31054
    por Huo, Zhen-yu, Peng, Li
    Publicado 2016
    “…Previous analyses did not set up rational inclusive criteria for screening articles with strict control groups and a gold standard for ATB diagnosis. …”
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    Accuracy of the interferon-γ release assay for the diagnosis of active tuberculosis among HIV-seropositive individuals: a systematic review and meta-analysis
  15. 31055
    “…CONCLUSIONS: The parameters and PK/PD model derived from this study pave the way to the further rational development of ferroquine as an anti-malarial partner drug. …”
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    A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study
  16. 31056
    “…Adhering with evidence-based guidelines represents the only rational approach to effective and safe PPI therapy. …”
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    Effective and safe proton pump inhibitor therapy in acid-related diseases – A position paper addressing benefits and potential harms of acid suppression
  17. 31057
    “…Integrating D-R/E-R relationships with efficacy data and a safety profile that is unique to I-O therapy is a rational approach for dose selection of these agents. …”
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    Nivolumab dose selection: challenges, opportunities, and lessons learned for cancer immunotherapy
  18. 31058
    “…Feed intake, percent hen-day egg production, egg weight, egg mass production, feed conversion ratio (FCR), and economics of supplementation of salts of organic acids in layers’ ration were evaluated. RESULTS: The dietary supplementation of salts of organic acids did not significantly affect the feed intake (g/day/hen) and body weight gain (g). …”
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    The effect of dietary supplementation of salts of organic acid on production performance of laying hens
  19. 31059
    “…Discovery and identification of anthelmintic resistance-associate molecules/markers can provide a basis for rational anthelmintics-use and development of novel drugs. …”
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    Genome-wide SNP analysis using 2b-RAD sequencing identifies the candidate genes putatively associated with resistance to ivermectin in Haemonchus contortus
  20. 31060
    “…The measurements have been reproduced and rationalized from first-principles by 2-D (r, z) coupled kinetic and transport modeling, and comparison between experiment and simulation has afforded a detailed understanding of C/N/H plasma-chemical reactivity and variations with process conditions and with location within the reactor. …”
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    Microwave Plasma-Activated Chemical Vapor Deposition of Nitrogen-Doped Diamond. II: CH(4)/N(2)/H(2) Plasmas
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