“…Therefore, the MSPC1 was a better source of SID Lys and digestible energy than either MSPC2 or SBM and could be used as a highly digestible protein ingredient in swine rations.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…ABSTRACT: Due to the intensive development of technologies for obtaining protein, energy feed and biologically active supplements from insects, the feasibility and effectiveness of introducing these products into the rations of farm animals require further study. This research aims to study the possibility and effects of feeding dairy cows fat from the larvae of the black soldier fly (BSFLF). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The incorporation of A. mearnssi forage in the ration had a reducing effect on GHG production and possibly improved utilization of dietary protein in response to the presence of tannins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, there is an increase in antimicrobial resistance to commonly used antibiotics. Hence to promote rational use of antibiotics, we aimed at establishing the etiology, local susceptibility patterns and outcome of children with sepsis aged 2 months to 15 years, admitted at Muhimbili National Hospital (MNH), Dar es Salaam. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, the wide use of psychotropics with weak clinical evidence raises serious concerns regarding rational use. Greater efforts are needed to increase the availability of psychotropic medicines and to facilitate proper psychotropic use.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cattle were fed with a total mixed ration (TMR) and supplemented with HY at 0, 1, 2, and 3 g/kg dry matter (DM), respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Control of inflammation and rationalization of treatment are necessary.…”
Enlace del recurso
Enlace del recurso

“…In conclusion, our study provides a rational basis for TAM sparing ADAM8-targeting in GBM to optimize standard chemotherapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Hypertensive disorders of pregnancy were not associated with breastfeeding intention (odds ration [OR] 1.30, 95% confidence interval [CI] 0.47–3.03, P = 0.57), intended breastfeeding duration (b = −3.28, 95% CI −7.04 to 0.48, P = 0.09), or initiation (OR = 0.64, 95% CI 0.29– 1.65, P = 0.32), but were associated with an increase in the odds of non‐exclusive breastfeeding at 4 months postpartum (OR = 2.11, 95% CI 1.39–3.22, P < 0.001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Within each block (baseline milk yield), cows were randomly assigned to: control (no microbial feed supplementation), MFS1 (0.33 g/kg total mixed ration [TMR] of an MFS containing a minimum of Clostridium beijerinckii at 2 × 10(6) CFU/g and Pichia kudriavzevii at 2 × 10(7) CFU/g), or MFS2 (0.33 g/kg TMR of a MFS containing a minimum of C. beijerinckii at 2 × 10(6) CFU/g, P. kudriavzevii at 2 × 10(7) CFU/g, Ruminococcus bovis at 2 × 10(7) CFU/g, and Butyrivibrio fibrisolvens at 2 × 10(7) CFU/g). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To this aim, we developed a rationally designed live attenuated ASFV-Δ110-9L/505-7R mutant based on the highly pathogenic Genotype II ASFV CN/GS/2018 backbone by deleting 2 well-characterized interferon inhibitors MGF110-9L and MGF505-7R. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among the examined compounds, Ph(2)SnL(1) complex (MIC = 0.0095 µmol/mL) was found to be the most active. To rationalize the preferred mode of interactions of the most active compound, a molecular docking study of compound Ph(2)SnL(1) was executed in the binding site of 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of E. coli and sterol 14-alpha demethylase of C. albicans. …”
Enlace del recurso
Enlace del recurso

“…The CH1 domain was identified as a conserved interaction site for IgG1 and IgG4 mAbs against the HCPs phospholipase B-like protein (PLBL2) and lysosomal phospholipase A2 (LPLA2). Rationally designed mutations in the CH1 domain of the IgG4 mAb caused a 3- to 70-fold K(D) reduction against PLBL2 by surface plasmon resonance (SPR). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The calves were kept in individual pens (1.5 × 3 m) and fed similar pellet and grass hay rations. Three troughs (14 L) of water were provided for each heifer calf and refreshed 3 times per day. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cows were fed the diets as a total mixed ration (TMR) for ad libitum DMI once daily. Analysis showed numerical increases in performance variables such as milk yield and fat and protein contents in both MFS1 and MFS2, although the differences were not significant over time. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, there is a critical need for obesity medications that provide glycemic control with enhanced hypophagic response without nausea/emesis. Based on rational design and in silico modelling of the glucagon-like peptide 1-receptor agonist (GLP1RA) exendin-4 (Ex4) and the neuropeptide Y2 receptor (Y2R) agonist peptide YY (PYY) 3-36, we have developed and screeened several new monomeric chimeric peptides that display dual agonism of the anorectic Y2R and the glucoregulatory GLP1R. …”
Enlace del recurso
Enlace del recurso

“…Taken together, the results of this study reveal an antagonistic mechanism by which pH240R suppresses the host immune response by manipulating activation of the NF-κB signaling and NLRP3 inflammasome, which might guide the rational design of live attenuated vaccines or therapeutic strategies against ASF in the future. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Future research will focus on enhancing the degree of rational drug use among outpatients and realizing the economical, safe, and effective use of pharmaceuticals to lessen the economic burden of patients.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our data demonstrate that the antigenic distances of representative swine strains from human vaccine strains represent an important part of the rational assessment of swine IAV for zoonotic risk research and pandemic preparedness prioritization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…One strategy to face this problem in a reasonable way is training health personnel for the rational use of antimicrobials. There are some difficulties associated with medical staff to receiving training with E-learning education, but there is a lack of studies and insufficient evidence of the effectiveness of this method compared to face-to-face learning. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso