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  1. 31221
    “…Targeting NFκB signaling through small molecule inhibitors may be a rational strategy to conquer chemoresistance and synergize platinum-based chemotherapy in KIAA1522 overexpressed lung adenocarcinomas.…”
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    KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma
  2. 31222
    “…Exploring the substantive impact of the internet on medical decision making is of great significance for further rational planning and utilization of the internet, in order to guide patients to appropriate medical institution.…”
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    Impact of the Internet on Medical Decisions of Chinese Adults: Longitudinal Data Analysis
  3. 31223
    “…We thus propose that NADPH cofactor engineering is indeed a valid strategy for metabolic engineering of A. niger to improve GlaA production, a strategy which is certainly also applicable to the rational design of other microbial cell factories. …”
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    Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger
  4. 31224
    “…Optimal padsevonil occupancy associated with non-clinical efficacy was translatable to humans for both molecular targets: high (>90%), sustained synaptic vesicle protein 2A occupancy and 10–15% transient GABA(A) receptor occupancy. Rational dose selection enabled clinical evaluation of padsevonil in a Phase IIa proof-of-concept trial (NCT02495844), with a single-dose arm (400 mg bid). …”
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    Padsevonil randomized Phase IIa trial in treatment-resistant focal epilepsy: a translational approach
  5. 31225
    “…The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies. …”
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    YAP and endothelin-1 signaling: an emerging alliance in cancer
  6. 31226
    “…Consistent with Degen et al. (2020), we conclude that listeners benefit from non-contrastive information that improves reference precision, and engage in rational reference comprehension. SIGNIFICANCE STATEMENT: This study investigated whether providing more information than someone needs to find an object in a photograph helps them to find that object more easily, even though it means they need to interpret a more complicated sentence. …”
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    When more is more: redundant modifiers can facilitate visual search
  7. 31227
    “…MRI pattern recognition can enable rationalization of investigations and also complement clinical and molecular findings, particularly confirming genomic findings and also enabling new gene discovery. …”
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    Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders
  8. 31228
    “…BACKGROUND: Integrated vector management (IVM) is defined as a rational decision-making process for the optimal use of resources for vector control. …”
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    Strengthening community and stakeholder participation in the implementation of integrated vector management for malaria control in western Kenya: a case study
  9. 31229
    “…All respondents reported shortages or rationing of at least one type of medical resource (e.g., sanitizing supplies and personal protective equipment). …”
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    Protecting providers and patients: results of an Internet survey of health care workers’ risk perceptions and ethical concerns during the COVID-19 pandemic
  10. 31230
    “…CONCLUSIONS: Mechanistic insights into differential IL-2c and αPD-L1 treatment and tissue-dependent effects could help develop rational combination treatment strategies to improve treatment efficacy in distinct cancers. …”
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    CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation
  11. 31231
    “…HMTBa was supplied in milk, and the amount of concentrated ration and hay provided and leftovers were recorded daily to estimate dry matter (DM) and crude protein consumption. …”
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    Performance and serum parameters of calves (Bos taurus) subject to milk restriction associated with supplementation with 2-hydroxy-4-(methylthio)butanoic acid
  12. 31232
    “…LC did not correlate with any TDR, but tumor response (partial response [PR] or complete response [CR]) correlated with all TDR in univariate analysis (e.g., TDR(60min,98%): hazard ration [HR] = 0.974, confidence interval [CI] = 0.952–0.996, p = 0.019). …”
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    Tumor-dose-rate variations during robotic radiosurgery of oligo and multiple brain metastases
  13. 31233
    “…Using the nomogram model may constitute a usefully clinical tool to guide a rational and personalized subsequent therapeutic choice.…”
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    Preoperative nomogram for microvascular invasion prediction based on clinical database in hepatocellular carcinoma
  14. 31234
    “…Robust predictive biomarkers for rational upfront therapy decisions are lacking, although they are urgently needed. …”
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    Online Artículo Texto
    CTLA4 promoter hypomethylation is a negative prognostic biomarker at initial diagnosis but predicts response and favorable outcome to anti-PD-1 based immunotherapy in clear cell renal cell carcinoma
  15. 31235
    “…Corresponding clinical trials vary considerably in the outcome measures assessing the efficacy of TCM, some that showed the improvement of clinical symptoms are not universally acknowledged. Rational outcome measures are the key to evaluate efficacy and safety of each treatment and significant elements of a convincing clinical trial. …”
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    Problems with the outcome measures in randomized controlled trials of traditional Chinese medicine in treating chronic heart failure caused by coronary heart disease: a systematic review
  16. 31236
    por Gao, Shan, Wang, Hanyi
    Publicado 2022
    “…It could provide corresponding decisions for the prevention and control of COVID based on the relevant parameters of the infectious disease dynamic model, which verified the rationality and feasibility of the scenario deduction method proposed in this study.…”
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    Scenario prediction of public health emergencies using infectious disease dynamics model and dynamic Bayes
  17. 31237
    “…In other domains, most algorithms are based on big data to help diagnose and suggest rational treatment options in medicine. But data in psychiatry are related to behavior and clinical evaluation. …”
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    Prevention of Suicidal Relapses in Adolescents With a Smartphone Application: Bayesian Network Analysis of a Preclinical Trial Using In Silico Patient Simulations
  18. 31238
    “…CONCLUSIONS: PEEP(upper) is a rational selection in ARDS cases with two similar best Crs. …”
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    Electrical Impedance Tomography Analysis Between Two Similar Respiratory System Compliance During Decremetal PEEP Titration in ARDS Patients
  19. 31239
    “…CONCLUSION: The population-based nomogram could help clinicians predict the occurrence and prognosis of DM in T1N0 CC patients and provide a reference to perform appropriate metastatic screening plans and rational therapeutic options for the special population.…”
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    Nomogram to Predict the Occurrence and Prognosis of Distant Metastasis in T1N0 Colon Cancer: A SEER Data-Based Study
  20. 31240
    “…Accordingly, supplements should be prescribed rationally even in dental caries. HOW TO CITE THIS ARTICLE: Jha A, Jha S, Shree R, et al. …”
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    Association between Serum Ferritin, Hemoglobin, Vitamin D(3), Serum Albumin, Calcium, Thyrotropin-releasing Hormone with Early Childhood Caries: A Case–Control Study
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