“…The high quality in terms of actinide to backing mass ration, large surface and thickness have been crucial to overcome the limitations of previous similar capture experiments. …”
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“…The complexity of issues requiring rational decision making grows and thus such decisions are becoming more and more difficult, despite advances in methodology and tools for decision support and in other areas of research. …”
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“…A non-parametric analytical tool (binary logistic regression) was applied to rationalize the study objectives and a Chi-squared test was performed to estimate the booster- hesitant risky group. …”
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“…SIMPLE SUMMARY: To reduce the impact of livestock on the environment, in modern rations for farm animals the concentration of relevant nutrients is aimed to be lowered. …”
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“…The current experiment investigated the effect of four isonitrogenous (14.7% crude protein) rations formulated to supply low (Lo-ME) or high (Hi-ME) metabolizable energy based on enset leaf (Ensete ventricosum) and commercial concentrate and the effects on local Doyogena ewes in Ethiopia. …”
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“…The information provided here is relevant for the rational design of control strategies in the context of integrated vector management. …”
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“…HS135 is an activin receptor ectodomain-based (ActRII) Fc-fusion protein, rationally designed to achieve best-in-class potency against activins and GDFs, without dose-limiting effects that would impede achieving full activity. …”
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“…AZP-3813 is a 16-amino acid, bicyclic peptide antagonist of the GH receptor (GHR) derived from peptide sequences discovered using a unique, cell-free in vitro transcription-translation system screened against the human GHR, and optimized by rational design to increase binding affinity, solubility and half-life. …”
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“…Our computational analysis provided a rationalization of the ability of naturally occurring withaferin A to alter the NF-κB signalling pathway along with its proposed mode of inhibition of the pathway. …”
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“…CONCLUSIONS: The priority actions to rationalize the use of antibacterials in the preschool age should concentrate on the active participation of the pediatricians in permanent education activities. …”
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“…CONCLUSION: Clinical professionals should enhance risk management regarding the combination use of two classes of drugs by increasing their awareness of the potential changes in therapeutic efficacy and adverse drug reactions, by rationally prescribing alternatives, by paying attention to dose adjustment and the administration schedule, and by review of the appropriateness of physician orders. …”
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“…Genome-based comparison of drug targets together with quantitative tissue expression analysis allows rational prediction of pharmacology and cross-reactivity of human drugs in animal models thereby improving drug attrition which is an important challenge in the process of drug development. …”
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“…A recently published metaanalysis of 5,508 patients in 9 RCT’s confirmed a cost savings of 48% with a pooled hazard ration for overall survival of 1.02 in favour of IAS (95% CI, 0.94 to 1.11). …”
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“…However, because the residue limits and food safety policies were revised on an ad hoc, emergency basis after the nuclear accident, the monitoring procedure needs to be reviewed based on objective and scientifically rational criteria. A transparent and objective scientific framework is needed for prioritizing foodstuffs for inspection and revising Prefecture-specific restrictions. …”
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“…Qualitative analysis is needed to address differences in context in order to implement this strategy to improve rational antibiotic use for patients with acute respiratory infection in low-income and middle-income countries. …”
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“…Alternatively, unique phospho-PR target gene sets may provide useful tools with which to identify patients likely to respond to selective PR modulators that block PR Ser294 phosphorylation as part of rational combination (i.e., with antiestrogens) endocrine therapies designed to durably block breast cancer recurrence. …”
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“…BACKGROUND: In previous reports, Marrero-Ponce et al. proposed algebraic formalisms for characterizing topological (2D) and chiral (2.5D) molecular features through atom- and bond-based ToMoCoMD-CARDD (acronym for Topological Molecular Computational Design-Computer Aided Rational Drug Design) molecular descriptors. These MDs codify molecular information based on the bilinear, quadratic and linear algebraic forms and the graph-theoretical electronic-density and edge-adjacency matrices in order to consider atom- and bond-based relations, respectively. …”
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“…We currently lack an understanding of the extent to which this metabolism varies between individuals, the mechanisms by which these microbial activities influence human biology, and how we might rationally manipulate these reactions. This deficiency stems largely from the difficulty of connecting this microbial chemistry to specific organisms, genes, and enzymes. …”
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“…Based on the ability of ETX2514, a rationally designed novel diazabicyclooctane inhibitor (Figure 1A), to inhibit class D β-lactamases as well as PBPs, we hypothesized that highly resistant clinical isolates of A. baumannii will demonstrate susceptibility to the sulbactam-ETX2514 combination and that A. baumannii β-lactamases, ADC-7 and OXA-58 will be readily inactivated by ETX2514. …”
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“…The goal of the study was to identify integrated management options for further improving productivity and profitability while rationalizing resource use and reducing environmental externalities (i.e., “sustainable intensification”, SI) by drawing on the principles of diversification, precision management, and conservation agriculture. …”
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