“…Adaptive enrichment designs and strategies are important components of a rational approach to achieve clinical research objectives in shorter clinical trial timelines and with increased cost-effectiveness without compromising ethical standards or the overall statistical integrity of the study. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Assessment of the Weekly AdministRation of dulaglutide in Diabetes (AWARD) China 1 (CHN1) study (NCT01644500, n = 556) included patients on dulaglutide vs. glimepiride who were treatment naïve or on monotherapy but discontinued therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also refer to works in social cognitive psychology explaining how, in an anxiety-provoking situation, reasoning can be biased and lead to choices that ultimately prove to be not very rational, in the opinion of those who made them. The current situation in the health sector is favourable in this, as evidenced by the “debate on chloroquine” widely reported in the media and on social networks, opposing conclusions most often decided on the basis of beliefs on contrary to evidence based medicine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cows were housed in well-ventilated individual pens and fed a total mixed ration (TMR) comprising 70% roughage and 30% concentrate. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The role of antigen presentation by DCs, particularly CD103(+) DCs, is critical to drive antitumor immunity providing rational to combine a priming agent AZD4635 with check point blockade. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This view clashes with a longlasting assumption ordering traffic flows, the rational driver postulate (i.e., drivers’ alleged propensity to maintain a safe distance). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Report format, content and context are of utmost importance for further analysis: A distinction has to be made between reports that contain locally rational information and cannot be understood without further context and reports that may help inform about patient safety activities on a national level. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The pooled analysis showed no significant difference in all-cause mortality (risk ration [RR] = 0.93, 95% CI [0.52, 1.67]), serious adverse events (RR = 0.96, 95% CI [0.79, 1.17]) and adverse events (RR = 1.00, 95% CI [0.99, 1.02]) between the two, but in hypoglycemia (RR = 0.13, 95% CI [0.10, 0.17], P < 0.001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A common belief is that one should only include enough corn silage in a finishing ration to maintain rumen health. However, previous research conducted by our research group suggested that feeding increased levels of corn silage could increase the quantity of beef produced per hectare of cropland. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cows were consuming a midlactation total mixed ration (TMR; 1.60 Mcal/kg DM and 15.4%; net energy of lactation and crude protein, respectively). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PURPOSE: Some patients make a rational choice not to follow medical prescriptions; others fail to take their medications for reasons beyond their control, such as mere forgetfulness or a weak medication routine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The animals were offered total mixed ration with supplementary four levels of rumen-protected lysine and methionine throughout the whole experiment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It was suggested that the clinical application of the steroidal alkaloids veratramine and Jervine in Radix Veratri required rational use of drugs based on gender. CONCLUSION: An LC-MS/MS analysis method suitable for the pharmacokinetic study of veratramine and Jervine in Radix Veratri in SD rats was established to provide a basis for in vivo pharmacokinetic studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, the society should strengthen positive cognitive education, carry out targeted education for relevant personnel, correctly guide positive emotions, turn some anxiety and impulsive emotions into rational motives, and guide them to carry out relevant activities according to their own advantages and characteristics. …”
Enlace del recurso
Enlace del recurso

“…Negative emotions should be guided in time; The dedication of rescue workers and the spirit of mutual assistance of all parties in case of difficulties have stimulated the positive emotions of netizens; In terms of emotional guidance of Internet users, the government and media departments respond to the concerns of Internet users in a timely and accurate manner, which is helpful to dredge the Internet emotion; Effective information supply and topic focus transfer help to promote the rationalization of network emotion. Through the research, it is found that with the continuous development of the Internet, public emotional behavior will have an important impact on microblog public opinion. …”
Enlace del recurso
Enlace del recurso

“…Whereas previous studies did not demonstrate significant benefit of anti-IL-17A therapy for severe COVID-19, our data suggest that such therapy could be a rational choice for mild-to-moderate disease, considering the generally high safety profile of IL-17A blockers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Nanomaterials have many advantages over traditional antibiotics, including improved stability, controlled antibiotic release, targeted administration, enhanced bioavailability, and the use of antibiotic-loaded nanomaterials, such as the one herein reported for the first time, appear to be a promising strategy to combat antibiotic-resistant bacteria. The use of rationally designed metallic nanocomposites, rather than the use of single metallic nanoparticles (NPs), should further minimize the bacterial resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The DR for these births increased to 85.8%, 75.8%, 80.0%, and 82.5%, respectively. CONCLUSION: The rational use of ultrasound data can significantly improve the prediction of SGA statuses.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: High index of suspicion, early diagnosis, and appropriate management of mucormycosis can improve survival. Rational use of steroids and strict glycemic control in diabetic patients can prevent occurrence of mucormycosis. …”
Enlace del recurso
Enlace del recurso

“…Early diagnosis followed by rational antifungal therapy are essential for improved outcome.…”
Enlace del recurso
Enlace del recurso