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  1. 31461
    “…It casts a significant influence on the rational use of voriconazole. We conducted this study to investigate the relationship between steady-state voriconazole trough concentration (C(trough)) and adverse effects (AEs), especially hepatotoxicity. …”
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    Therapeutic drug monitoring and safety evaluation of voriconazole in the treatment of pulmonary fungal diseases
  2. 31462
    “…Between afternoon and morning milking, the cows were housed receiving a partial mixed ration and water ad libitum. The effect of treatments on milk production, milk composition, body weight, rumen function, and blood parameters were analyzed using a linear–mixed model. …”
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    Effects of Sugar Beet Silage, High-Moisture Corn, and Corn Silage Feed Supplementation on the Performance of Dairy Cows with Restricted Daily Access to Pasture
  3. 31463
    “…In this study, we assessed the fecal microbiome of organic dairy cows across different time points receiving a mixed diet of pasture and total mixed ration (TMR) or TMR only. We hypothesized that the fecal methanogenic community, as well as co-occurrence patterns with bacteria, change across diets. …”
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    Contrasting Fecal Methanogenic and Bacterial Profiles of Organic Dairy Cows Located in Northwest Washington Receiving Either a Mixed Diet of Pasture and TMR or Solely TMR
  4. 31464
    “…First， the tandem MS spectra of peptide sequences are highly complex， which poses a great challenge for the strict and accurate matching of peptides based on the rational speculation of MS fragmentation rules and theoretical calculations in non-targeted proteomics. …”
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    疑似蛇毒液样品的纳升级超高效液相色谱-高分辨质谱分析鉴定
  5. 31465
    por Thompson, Eric M, Hielscher, Thomas, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E, Bigner, Darell D, Lipp, Eric S, Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Seung-Ki Kim Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Li, Kay Ka Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Low, David CY, Seow, Wan Tew, Chang, Kenneth TE, Mora, Jaume, Pollack, Ian F, Hamilton, Ronald L, Leary, Sarah, Moore, Andrew S., Ingram, Wendy J., Hallahan, Andrew R., Jouvet, Anne, Fèvre-Montange, Michelle, Vasiljevic, Alexandre, Faure-Conter, Cecile, Shofuda, Tomoko, Kagawa, Naoki, Hashimoto, Naoya, Jabado, Nada, Weil, Alexander G, Gayden, Tenzin, Wataya, Takafumi, Shalaby, Tarek, Grotzer, Michael, Zitterbart, Karel, Sterba, Jaroslav, Kren, Leos, Hortobágyi, Tibor, Klekner, Almos, László, Bognár, Pócza, Tímea, Hauser, Peter, Schüller, Ulrich, Jung, Shin, Jang, Woo-Youl, French, Pim J, Kros, Johan M, van Veelen, Marie-Lise C, Massimi, Luca, Leonard, Jeffrey R, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Cooper, Michael K, Thompson, Reid C, Faria, Claudia C, Carvalho, Alice, Nunes, Sofia, Pimentel, José, Fan, Xing, Muraszko, Karin M, López-Aguilar, Enrique, Lyden, David, Garzia, Livia, Shih, David JH, Kijima, Noriyuki, Schneider, Christian, Adamski, Jennifer, Northcott, Paul A, Kool, Marcel, Jones, David TW, Chan, Jennifer A, Nikolic, Ana, Garre, Maria Luisa, Van Meir, Erwin G, Osuka, Satoru, Olson, Jeffrey J, Jahangiri, Arman, Castro, Brandyn A., Gupta, Nalin, Weiss, William A, Moxon-Emre, Iska, Mabbott, Donald J, Lassaletta, Alvaro, Hawkins, Cynthia E, Tabori, Uri, Drake, James, Kulkarni, Abhaya, Dirks, Peter, Rutka, James T, Korshunov, Andrey, Pfister, Stefan M, Packer, Roger J, Ramaswamy, Vijay, Taylor, Michael D
    Publicado 2016
    “…There was an observed PFS benefit of GTR over STR (hazard ration [HR] 1·45, 95% CI; 1·07–1·96, p=0·02) but there was no observed PFS or OS benefit of GTR over NTR (HR 1·05, 0·71–1·53, p=0·82 and HR 1·14, 0·75–1·72, p=0.55). …”
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    Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup: An Integrated Clinical and Molecular Analysis
  6. 31466
    “…Importantly, this study provided a strategy for the rational design of a protein corona-based brain-targeted drug delivery system. …”
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    Novel brain-targeted nanomicelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo
  7. 31467
    “…This is why in 2004, the health authorities decided to revise the policy of malaria management by adopting a new strategy based on the rational use of artemisininbased combination therapies after the biological confirmation of suspected malaria cases. …”
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    Influence de la numération leucocytaire sur la densité parasitaire dans le paludisme simple chez les enfants de 6 à 59 mois au Bénin
  8. 31468
    “…However, no systematic studies of PCOS have been performed in Sub-Sahara Africa, limiting the ability to develop rational screening and public health approaches to address the disorder in this part of the world. …”
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    SAT363 The Prevalence And Phenotype Of Polycystic Ovary Syndrome (PCOS) In A Community-Based Population In Sub-Sahara Africa: The Nigeria-PEP Study
  9. 31469
    “…AR, extracellular matrix (ECM) remodeling marker MMP9, pro-fibrotic marker TGF-β, renal injury markers (urinary albumin to creatinine ration (UACR), KIM1, and NGAL) were assessed by Western-blot or ELISA. …”
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    OR35-02 Novel Androgen Receptor PROTAC Degrader ARV-110 Ameliorates Androgen Mediated Renal Injury in a Mouse Model of Polycystic Ovary Syndrome
  10. 31470
    “…The previously reported yeast strain BP10001, which expresses heterologous xylose reductase from Candida tenuis in mutated (NADH-preferring) form, stands for a series of other yeast strains designed with similar rational. Using 20 g/L xylose as sole source of carbon, BP10001 displayed a low specific uptake rate q(xylose )(g xylose/g dry cell weight/h) of 0.08. …”
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    Fermentation of mixed glucose-xylose substrates by engineered strains of Saccharomyces cerevisiae: role of the coenzyme specificity of xylose reductase, and effect of glucose on xylose utilization
  11. 31471
    “…BACKGROUND: The key to understanding changes in gene expression levels using reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR) relies on the ability to rationalize the technique using internal control genes (ICGs). …”
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    The dilution effect and the importance of selecting the right internal control genes for RT-qPCR: a paradigmatic approach in fetal sheep
  12. 31472
    “…This is the first proof-of-principle study to show that high anti-stalk titres can be induced by a rationally designed vaccine in humans and opens up avenues for further development of universal influenza virus vaccines. …”
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    Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial
  13. 31473
    “…Because the major attributable LSD-associated and MSD-associated pathogens are the same, implementing vaccines and rapid diagnosis and treatment interventions against these major pathogens are rational investments. FUNDING: Bill & Melinda Gates Foundation.…”
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    Diarrhoeal disease and subsequent risk of death in infants and children residing in low-income and middle-income countries: analysis of the GEMS case-control study and 12-month GEMS-1A follow-on study
  14. 31474
    “…Antimicrobial prophylaxis was prescribed rationally and was not recommended, except for patients with a long course of disease, repeated fever, and elevated procalcitonin, similarly secondary fungal infections were of concern. …”
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    Translation: Management of Coronavirus Disease 2019 (COVID-19): Experience in Zhejiang Province, China
  15. 31475
    “…Comprehensive characterisation of clinical syndromes is crucial to allow rational selection and evaluation of potential therapies. …”
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    Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study
  16. 31476
    “…SIMPLE SUMMARY: New Zealand dairy cows predominantly feed on pasture with protein to energy ratios well in excess of requirements and consequently their urine has a substantially greater concentration of nitrogen compared to cows fed indoors on total mixed rations. The nitrogen excreted directly onto land decompose into nitrous oxide and ammonium, causing global warming and freshwater pollution, respectively. …”
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    Can Nitrogen Excretion of Dairy Cows Be Reduced by Genetic Selection for Low Milk Urea Nitrogen Concentration?
  17. 31477
    por Bowman, Clive E.
    Publicado 2021
    “…This review shows that predatory mesostigmatids do have cheliceral designs with clear rational purposes. Almost invariably within an overall body size class, the switch in predatory style from a worm-like prey feeding (‘crushing/mashing’ kill) functional group to a micro-arthropod feeding (‘active prey cutting/slicing/slashing' kill) functional group is matched by: an increased cheliceral reach, a bigger chelal gape, a larger morphologically estimated chelal crunch force, and a drop in the adductive lever arm velocity ratio of the chela. …”
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    Feeding design in free-living mesostigmatid chelicerae (Acari: Anactinotrichida)
  18. 31478
    “…Holstein bull calves in the control group (COG) were fed a basal total mixed ration (TMR), while experimental treatments (BMG) were fed with the TMR diet supplemented with 12 g/head/day of BM1259 powder (1 × 10(10) cfu/g) separately. …”
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    Effects of Bacillus megatherium 1259 on Growth Performance, Nutrient Digestibility, Rumen Fermentation, and Blood Biochemical Parameters in Holstein Bull Calves
  19. 31479
    “…We also found that demographic characteristics of the public can significantly influence attitude, with those respondents who are not vegetarian or religious, who have higher levels of education, or are younger in age being more likely to appreciate the rational science approach of SWM. Our research suggests that conservation organisations may need to adapt their management aims and practices to avoid direct conflict with the rising tide of animal rights sentiment. …”
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    Compassionate Conservation and the Challenge of Sustainable Wildlife Management: A Survey of the Urban Public of China
  20. 31480
    “…Patients who had medications deprescribed had nonsignificantly greater odds of dying within 90 days [odds ration (OR) = 3.23 (95% confidence interval (CI): 0.68, 14.92; p = 0.136]. …”
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    Prospective cohort study of nonspecific deprescribing in older medical inpatients being discharged to a nursing home
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