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“…Here, we combine the utility of nucleic acid aptamers with predictable control over the secondary structure to rationally design sequences with controlled affinity towards a target analyte when employed as the recognition element in an electrochemical sensor. …”
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“…While the concept of Nash equilibrium assumes perfect rationality, in reality players display heterogeneous bounded rationality. …”
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“…Here, we report that a triangular topology can be developed for the rational design and synthesis of a new class of COFs. …”
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“…We demonstrated that FMAP could be used to rationalize improvement in the activity of known protein inhibitors upon introduction of fluorine. …”
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“…In this review, these risks are identified and recommendations are made for the rational prescribing of the drug in light of current evidence.…”
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“…OBJECTIVES: To investigate the rational use of drugs from patient’s perspective. METHODS: This study was conducted at the Afyon Kocatepe University Training and Research Hospital between February and March 2013. …”
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“…With modern fabrication tools a large variety of possibilities is available for shaping both nanoparticles and nanocavities; in particular nanocavities in thin metal films have emerged as attractive candidates for new metamaterials and strong linear and nonlinear optical systems. Here we rationally design metallic nanocavities to boost their Four-Wave Mixing response by resonating the optical plasmonic resonances with the incoming and generated beams. …”
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“…Here, we show that halotolerance can be generated in an enzyme solely by modifying surface residues. Rational design of carbonic anhydrase II is undertaken in three stages replacing 18 residues in total, crystal structures confirm changes are confined to surface residues. …”
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“…In such settings, we present a scenario where a rational player is able to make better use of his/her weak preferences due to quantum reasoning, without any altering or resetting of the classically defined game. …”
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“…Rational: Studies conducted showed that there were gaps regarding the rational use of medicines (RUM). …”
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“…Resource-constrained settings use risk profiling to ration the use of drug susceptibility testing (DST). …”
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“…Rational flux design in metabolic engineering approaches remains difficult since important pathway information is frequently not available. …”
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“…The aim of the present study was to provide a guide to ameliorate the appropriate and rational use of clinical antimicrobial agents by analyzing the distribution of drug-resistant pathogenic bacteria in patients. …”
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