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  1. 1081
    “…To overcome this limitation, we created more thermostable variants using semi-rational design. The amino acids for substitution were chosen according to the B factor in combination with four additional knowledge-based criteria. …”
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    Thermostabilization of the uronate dehydrogenase from Agrobacterium tumefaciens by semi-rational design
  2. 1082
    “…Nevertheless, clinical efficacy for CNS indications is lacking, and one reason for this is the relatively limited spread and transduction efficacy in large regions of the human brain. Using rationally designed modifications of the capsid, novel AAV capsids have been generated that improve intracellular processing and result in increased transgene expression. …”
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    Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
  3. 1083
    “…We conclude that such information will ultimately lead to an accurate understanding of the relationship between the bulk scale catalyst behavior and the nanoscale structural features, enabling a rationalization of catalyst design.…”
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    Rationalizing Acid Zeolite Performance on the Nanoscale by Correlative Fluorescence and Electron Microscopy
  4. 1084
    Publicado 1840
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    An Essay on the Treatment and Cure of Pulmonary Consumption, on Principles Natural, Rational, and Successful
  5. 1085
    por Pulcu, Erdem, Browning, Michael
    Publicado 2017
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    Correction: Affective bias as a rational response to the statistics of rewards and punishments
  6. 1086
    “…The Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos –Serviços (PNAUM – National Survey on Access, Use and Promotion of Rational Use of Medicines – Services) aimed to characterize the organization of pharmaceutical services in the Primary Health Care of the Brazilian Unified Health System (SUS). …”
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    National Survey on Access, Use and Promotion of Rational Use of Medicines: methods
  7. 1087
    “…By using the structure-based rational approach, the N-terminal sequence of TlXyn11B was modified for thermostability improvement. …”
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    Thermostability improvement of a Talaromyces leycettanus xylanase by rational protein engineering
  8. 1088
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    Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
  9. 1089
    “…Cholesterol oxidase catalyzes the oxidation and isomerization of the cholestane substrates leading to the addition of a hydroxyl group at the C3 position. Rational engineering of the cholesterol oxidase from Pimelobacter simplex (PsChO) was performed. …”
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    Rational design of cholesterol oxidase for efficient bioresolution of cholestane skeleton substrates
  10. 1090
    “…Combined, our multi-disciplinary study further reinforces that junction sterics and connectivity are important determinants of RNA folding, and demonstrates the potential of coarse-grained simulations as a tool for rationally tuning and optimizing RNA folding and function.…”
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    Tuning RNA folding and function through rational design of junction topology
  11. 1091
    “…We then devised ‘metabolically rationalized standard’ assay conditions, in which glutaminase-1 inhibition reduced glutamine metabolism differently in both cell lines assayed, and decreased the proliferation of one of them. …”
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    Rational cell culture optimization enhances experimental reproducibility in cancer cells
  12. 1092
    por Bennett, J. Hughes
    Publicado 1846
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    Contributions to Pathology and Rational Medicine: No. 3.—On Anormal Nutrition and Diseases of the Blood
  13. 1093
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    Rational Modification of a Metallic Substrate for CVD Growth of Carbon Nanotubes
  14. 1094
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    Simulation and Analysis of Mechanical Properties of Silica Aerogels: From Rationalization to Prediction
  15. 1095
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    Immunology of Cryptococcal Infections: Developing a Rational Approach to Patient Therapy
  16. 1096
    “…Accordingly, there is growing interest in the rational design of electrolytes for beyond lithium-ion systems by tuning the molecular-level interactions of solvate species present in the electrolytes. …”
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    Elucidating Solvation Structures for Rational Design of Multivalent Electrolytes—A Review
  17. 1097
    Publicado 1834
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    A Rational Exposition of the Physical Signs of the Diseases of the Lungs and Pleura, &c.
  18. 1098
    “…BACKGROUND: For rational decision making, assessing the cost-effectiveness and budget impact of new drugs and comparing the costs of drugs already on the market is required. …”
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    Evidence on the cost of breast cancer drugs is required for rational decision making
  19. 1099
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    Quantitative model for rationalizing solvent effect in noncovalent CH–Aryl interactions
  20. 1100
    “…Moreover, it discusses the application of the label “irrational” for biased decisions and proposes reasons for instrumental rationality, which exist at an unconscious, need-regulative level.…”
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    Motivational Reasons for Biased Decisions: The Sunk-Cost Effect’s Instrumental Rationality
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