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  1. 1641
    “…RESULTS: Based on a homology model of PsXR, six residues were predicted to interact with the adenine ribose of NAD(P)H in PsXR and altered using a semi-rational mutagenesis approach (CASTing). Three rounds of saturation mutagenesis were carried to randomize these residues, and a microplate-based assay was applied in the screening. …”
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    Altering coenzyme specificity of Pichia stipitis xylose reductase by the semi-rational approach CASTing
  2. 1642
    “…To increase the glucose uptake rate, we propose a rational strategy for designing the molecular architecture of the Escherichia coli glucose PTS by using a computer-aided design (CAD) system and verified the simulated results with biological experiments. …”
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    Computer-aided rational design of the phosphotransferase system for enhanced glucose uptake in Escherichia coli
  3. 1643
    “…A greater understanding of the molecular causes of castration resistance is allowing a more rational approach to the development of new drugs and many new agents are now in clinical development. …”
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    Improving the outcome of patients with castration-resistant prostate cancer through rational drug development
  4. 1644
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    Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers
  5. 1645
    “…BACKGROUND: It is ethically controversial whether medical doctors are morally permitted to ration the care of their patients at the bedside. …”
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    Bedside rationing by general practitioners: A postal survey in the Danish public healthcare system
  6. 1646
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    The Nutrition of the Mouse. VI. Growth Rates of Two Strains on Stock Rations and on Purified Diets
  7. 1647
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    Rational use of the fixed combination of dorzolamide – timolol in the management of raised intraocular pressure and glaucoma
  8. 1648
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    Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core
  9. 1649
    “…Due to the over-and misuse of anti-malarials, widespread resistance to all the known drugs is increasing at an alarming rate. Rational methods to select new drug target proteins and lead compounds are urgently needed. …”
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    Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria
  10. 1650
    “…It is hoped that translational genomic and proteomic research will discriminate more accurately than is possible at present between patients with a good prognosis and those who carry a high risk of recurrence. Rational treatments, targeted to the specific molecular pathways of an individual’s high-risk tumor, are at the core of tailored therapy. …”
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    The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients
  11. 1651
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    Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs
  12. 1652
    por Rowe, Bryan P, Glazer, Peter M
    Publicado 2010
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    Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms
  13. 1653
    “…Decision models such as these function under a shared assumption of rational choice and utility maximization in the decision-making process. …”
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    Rationality versus reality: the challenges of evidence-based decision making for health policy makers
  14. 1654
    por Bloomfield, Eric L.
    Publicado 2009
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    The Ethics of Rationing of Critical Care Services: Should Technology Assessment Play a Role?
  15. 1655
    “…We are at the point where an increasing number of modular, inter-changeable and well-characterized components is needed to expand the construction of synthetic devices and to allow a rational approach to the design. RESULTS: We used interchangeable modular biological parts to create a set of novel synthetic devices for controlling gene transcription, and we developed a mathematical model of the modular circuits. …”
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    Rational design of modular circuits for gene transcription: A test of the bottom-up approach
  16. 1656
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    Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010
  17. 1657
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    “Rational Vaccine Design” for HIV Should Take into Account the Adaptive Potential of Polyreactive Antibodies
  18. 1658
    por Roberts, David N, Miner, Philip B
    Publicado 2011
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    Safety aspects and rational use of a naproxen + esomeprazole combination in the treatment of rheumatoid disease
  19. 1659
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    Fractal-like Distributions over the Rational Numbers in High-throughput Biological and Clinical Data
  20. 1660
    por Dutta, Alipta, Chakraborty, Subrata
    Publicado 2010
    “…Rational drug use is a function of prescription practices having medical, social, and economic implications. …”
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    Practice of rational drug uses in a rural area of 24 pgs(s) in West Bengal
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