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  1. 1681
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    Rational use of medicine in the pediatric age group: A summary on the role of clinical pharmacists
  2. 1682
    por Canbakan, Başol
    Publicado 2013
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    Rational approaches to the treatment of hypertension: drug therapy—monotherapy, combination, or fixed-dose combination?
  3. 1683
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    Rational design of cyclopropane-based chiral PHOX ligands for intermolecular asymmetric Heck reaction
  4. 1684
    “…A new iterative scheme has been constructed for finding minimal solution of a rational matrix equation of the form X + A*X (−1) A = I. …”
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    An Inversion-Free Method for Finding Positive Definite Solution of a Rational Matrix Equation
  5. 1685
    “…In perinatal stroke where potential applications are promising, rational adaptation of dosage for children remains under investigation. …”
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    Pediatric stroke and transcranial direct current stimulation: methods for rational individualized dose optimization
  6. 1686
    “…We describe a strategy for rationally designing analogues of hIAPP with improved properties; key proline mutations are combined with substitutions that increase the net charge of the molecule. …”
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    Rationally Designed, Nontoxic, Nonamyloidogenic Analogues of Human Islet Amyloid Polypeptide with Improved Solubility
  7. 1687
    “…BACKGROUND: Implicit rationing of nursing care is the withholding of or failure to carry out all necessary nursing measures due to lack of resources. …”
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    Linking patient satisfaction with nursing care: the case of care rationing - a correlational study
  8. 1688
    “…We argue that predicted disability is relevant both indirectly and directly to rationing decisions.…”
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    Disability, discrimination and death: is it justified to ration life saving treatment for disabled newborn infants?
  9. 1689
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    BioGPS Descriptors for Rational Engineering of Enzyme Promiscuity and Structure Based Bioinformatic Analysis
  10. 1690
    “…This result demonstrates the use of metabolic engineering on rationally developed high producing natural variants for the production.…”
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    Metabolic Engineering of Rational Screened Saccharopolyspora spinosa for the Enhancement of Spinosyns A and D Production
  11. 1691
    por Hadd, Andrew, Perona, John J.
    Publicado 2014
    “…[Image: see text] We have taken a rational approach to redesigning the amino acid binding and aminoacyl–tRNA pairing specificities of bacterial glutaminyl–tRNA synthetase. …”
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    Recoding Aminoacyl-tRNA Synthetases for Synthetic Biology by Rational Protein-RNA Engineering
  12. 1692
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    A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies
  13. 1693
    “…Such uncertain regions can be used for a rational experimental design to render initially highly uncertain model predictions into certainty. …”
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    Rational selection of experimental readout and intervention sites for reducing uncertainties in computational model predictions
  14. 1694
    por Choi, Jay H., Ostermeier, Marc
    Publicado 2014
    “…As a step toward addressing this challenge, we describe the design, construction, and characterization of AND, ORN, and YES logic gates built by introducing disulfide bonds into RG13, a fusion of maltose binding protein and TEM-1 β-lactamase for which maltose is an allosteric activator of enzyme activity. We rationally designed these disulfide bonds to manipulate RG13’s allosteric regulation mechanism such that the gating had maltose and reducing agents as input signals, and the gates could be toggled between different gating functions using redox agents, although some gates performed suboptimally.…”
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    Rational Design of a Fusion Protein to Exhibit Disulfide-Mediated Logic Gate Behavior
  15. 1695
    “…This both verifies the dopamine-first mechanism and demonstrates the potential for the rational engineering of NCS activity.…”
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    ‘Dopamine-first’ mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile
  16. 1696
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    Improving the Oxidative Stability of a High Redox Potential Fungal Peroxidase by Rational Design
  17. 1697
    por Mittal, Niti, Gupta, Mahesh C.
    Publicado 2015
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    Comparison of agreement and rational uses of the WHO and Naranjo adverse event causality assessment tools
  18. 1698
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    Rational strategy to stop arrhythmias: Early afterdepolarizations and L-type Ca(2+) current
  19. 1699
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    The regional myocardial infarction registry of Saxony-Anhalt (RHESA) in Germany – rational and study protocol
  20. 1700
    “…Here we utilize in silico polymorph screening in combination with rationally planned crystallization experiments to study the polymorphism of the pharmaceutical compound Dalcetrapib, with 10 torsional degrees of freedom one of the most flexible molecules ever studied computationally. …”
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    Combined crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening
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