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  1. 1761
    “…RESULTS: In this paper, we have rationally engineered the tricarboxylic acid (TCA) cycle that increased the carbon yield (from 36.18 to 59.65%), final titer (from 14.47 ± 0.41 to 23.86 ± 2.16 g L(−1)) and productivity (from 0.30 to 0.50 g L(−1) h(−1)) of l-lysine by Corynebacterium glutamicum in shake-flask fermentation because of improving the OAA and l-glutamate availability. …”
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    Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum
  2. 1762
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    Concise Review: Rational Use of Mesenchymal Stem Cells in the Treatment of Ischemic Heart Disease
  3. 1763
    “…However, the entangled nature of arbitrary rational-order OAM has long been considered a myth due to the absence of an effective strategy for generating arbitrary rational-order OAM beams. …”
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    Spiniform phase-encoded metagratings entangling arbitrary rational-order orbital angular momentum
  4. 1764
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    Rational Use of Mechanical Circulatory Support as a Bridge to Pediatric and Congenital Heart Transplantation
  5. 1765
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    Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment
  6. 1766
    por van den Berg, Ronald, Ma, Wei Ji
    Publicado 2018
    “…Our findings raise the possibility that cognitive "limitations" arise from rational cost minimization rather than from constraints.…”
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    A resource-rational theory of set size effects in human visual working memory
  7. 1767
    “…Here, we propose a “rational metabolic-flow switching” strategy to efficiently produce exogenous secondary metabolites using suspension-cultured bamboo (Phyllostachys nigra; Pn) cells as model production hosts. …”
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    Rational metabolic-flow switching for the production of exogenous secondary metabolites in bamboo suspension cells
  8. 1768
    “…In order to directly convert alcohols into carboxylic acids, rational engineering of 5-(hydroxymethyl)furfural oxidase was performed. …”
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    Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids
  9. 1769
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    Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers
  10. 1770
    “…A new series of calix[n]arene analogues, benzimidazole[3]arenes, was rationally synthesized by Cu(II)-catalyzed post-macrocyclization transformation of a tris(o-phenylenediamine) macrocycle, and fully characterized by NMR, MS, and single-crystal X-ray diffraction (XRD) analyses. …”
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    Rational synthesis of benzimidazole[3]arenes by Cu(II)-catalyzed post-macrocyclization transformation
  11. 1771
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    Filling the Gaps: Current Research Directions for a Rational Use of Probiotics in Preterm Infants
  12. 1772
    “…Lessons from the limitations of approved NNRTIs and past development failures informed a rational approach to the development of DOR. METHODS: This review describes the development of DOR, which applied resistance selection and crystallography studies to improve resistance profiles, qEEG studies to evaluate CNS effects, and animal studies to optimize pharmacokinetic profiles, with confirmation in clinical trials. …”
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    545. Rational Design of Doravirine (DOR): A Review of Development From Bench to Patients
  13. 1773
    por Wu, Zhanxiong, Wu, Dongnan, Xu, Dong
    Publicado 2018
    “…Aiming to estimate 3D fiber pathways more accurately from orientation distribution function (ODF) fields, we presented a novel tracking method based on nonuniform rational B-splines (NURBS) curve fitting. First, we constructed ODF fields from high angular resolution diffusion imaging (HARDI) datasets using diffusion orientation transform (DOT) method. …”
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    White Matter Fiber Tractography Using Nonuniform Rational B-Splines Curve Fitting
  14. 1774
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    Improvement of isoprene production in Escherichia coli by rational optimization of RBSs and key enzymes screening
  15. 1775
    “…The analogues of BuIA with an appropriate and rational mutation showed high selectivity and maintained the regulation of Ca(2+) capacity in neurons and activities of analgesia, whereas the analogues demonstrated that the adverse effects of natural α-conotoxins could be reduced.…”
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    Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects
  16. 1776
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    Preoperative brain MRI for clinical stage IA lung cancer: is routine scanning rational?
  17. 1777
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    Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
  18. 1778
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    A Cue for Rational Reasoning: Introducing a Reference Point in Cognitive Reflection Tasks
  19. 1779
    por Jokić, Biljana, Purić, Danka
    Publicado 2019
    “…The usual distinction between rational and intuitive thinking styles is still a subject of scientific debate, as there is no consensus about their nature, mutual relations and relations to other personality constructs. …”
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    Relating Rational and Experiential Thinking Styles With Trait Emotional Intelligence in Broader Personality Space
  20. 1780
    “…In this review, we discuss a number of approaches developed by our University of Texas MD Anderson Lung Cancer Multidisciplinary Program to process and utilize such large datasets with the goal of identifying rational therapeutic options for biomarker-driven patient subsets. …”
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    Integrated Approaches for the Use of Large Datasets to Identify Rational Therapies for the Treatment of Lung Cancers
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