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  1. 1781
    “…Another factor to consider in the rational design of an HSV vaccine is adjuvant choice. …”
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    Mechanisms of Immune Control of Mucosal HSV Infection: A Guide to Rational Vaccine Design
  2. 1782
    “…Here we demonstrate efficient total biosynthetic and biocatalytic platforms that use a pair of fungal OMTs with orthogonal regiospecificity to produce unnatural O-methylated benzenediol lactone polyketides. We show that rational, structure-guided active-site cavity engineering can reprogram the regioselectivity of these enzymes. …”
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    Rational Reprogramming of O-Methylation Regioselectivity for Combinatorial Biosynthetic Tailoring of Benzenediol Lactone Scaffolds
  3. 1783
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    Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space
  4. 1784
    “…Rationality is introduced by means of a predictive rule for strategy update and is bounded by the assumed model society. …”
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    Direct reciprocity and model-predictive rationality explain network reciprocity over social ties
  5. 1785
    “…In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and computational studies. …”
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    Rational Design of Antiangiogenic Helical Oligopeptides Targeting the Vascular Endothelial Growth Factor Receptors
  6. 1786
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    The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta
  7. 1787
    “…To further development of FR or YM mimics for other Gα subunits, we here set out to rationally design Gα16 proteins with artificial FR/YM sensitivity by introducing an engineered depsipeptide-binding site. …”
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    Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
  8. 1788
    “…DNA-enabled molecular engineering allows the rational design of FRNPs with a detection limit as low as 5 × 10(−15) M. …”
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    DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy
  9. 1789
    “…RESULTS: Definitive (e.g., chromatography-based) testing is recommended as most clinically appropriate for UDM because of its accuracy; however, institutional or payer policies may require initial use of presumptive testing (i.e., immunoassay). The rational choice of substances to analyze for UDM involves considerations that are specific to each patient and related to illicit drug availability. …”
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    Rational Urine Drug Monitoring in Patients Receiving Opioids for Chronic Pain: Consensus Recommendations
  10. 1790
    por Li, Wei Vivian, Li, Jingyi Jessica
    Publicado 2019
    “…In an evaluation based on 17 cell types and 6 different protocols, scDesign outperformed four state-of-the-art scRNA-seq simulation methods and led to rational experimental design. In addition, scDesign demonstrates reproducibility across biological replicates and independent studies. …”
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    A statistical simulator scDesign for rational scRNA-seq experimental design
  11. 1791
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    A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease
  12. 1792
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    Rational Design of Toxoid Vaccine Candidates for Staphylococcus aureus Leukocidin AB (LukAB)
  13. 1793
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    Rational design of spontaneous reactions for protecting porous lithium electrodes in lithium–sulfur batteries
  14. 1794
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    Rationally Designed Circularly Arranged Sextuple Molecule with Dimethoxyphenolic Tentacles for Ample Hunting of Cyanide
  15. 1795
    “…Here, we present a structure-guided modelling-based strategy for the rational design of those enzymes essential for the development of XNA molecular biology. …”
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    Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins
  16. 1796
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    Optimization of alkaline protease production by rational deletion of sporulation related genes in Bacillus licheniformis
  17. 1797
    “…AIM: This study aimed to investigate effects of rations containing formaldehyde-protected soybean meal on meat production in Kacang goats. …”
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    Effects of rations containing formaldehyde-protected soybean meal on meat production in Kacang goats
  18. 1798
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    Turkish Society of Cardiology consensus report on the rational use of cardiac troponins in daily practice
  19. 1799
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    Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants
  20. 1800
    “…In the face of limited computational resources, bounded rational decision theory predicts that information-processing should be concentrated on actions that make a significant contribution in terms of the utility achieved. …”
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    Analyzing Abstraction and Hierarchical Decision-Making in Absolute Identification by Information-Theoretic Bounded Rationality
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