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1961por Feng, Yingting, Shao, Shuai, Zhou, Xueting, Wei, Wan, Liu, Xun, Tang, Yi, Hua, Yuhao, Zheng, Jianyong, Zhang, Yinjun, Ying, Xiangxian“…Herein, the glycolate oxidase from Chlamydomonas reinhardtii (CreGO) was selected through phylogenetic tree analysis, and its low level of soluble expression in E. coli BL21(DE3) was improved through the use of the glutathione thioltransferase (GST), the choice of the vector pET22b and the optimization of induction conditions. The semi-rational design of the fusion enzyme GST-Gly-Ser-Gly-CreGO led to the superior variant GST-Gly-Ser-Gly-CreGO-Y27S/V111G/V212R with the k(cat)/K(m) value of 29.2 s(−1)·mM(−1), which was six times higher than that of the wild type. …”
Publicado 2023
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1962por Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim“…Viral RNA cap synthesis involves two methylation steps, the first of which is mediated by the nsp14 protein. Here, we rationally designed and synthesized a series of compounds capable of binding to both the S-adenosyl-l-methionine and the RNA-binding site of SARS-CoV-2 nsp14 N(7)-methyltransferase. …”
Publicado 2023
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1963por Obiweluozo, Patience E, Dike, Ibiwari C, Ogba, Francisca N, Elom, Chinyere O, Orabueze, Florence O, Okoye-Ugwu, Stella, Ani, Casmir KC, Onu, Augustine O, Ukaogo, Victor, Obayi, Loveline N, Abonyi, Sunday E, Onu, Janefrancis, Omenma, Zippora O, Okoro, Ifeanyichukwu D, Eze, Angela, Igu, Ntasiobi CN, Onuigbo, Liziana N, Umeano, Elsie C, Onyishi, Charity N“…The waitlisted group also received a blended Rational Emotive Behavior Therapy intervention after all data collection. …”
Publicado 2021
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1964por Lathuiliere, Aurelien, Jo, Youhwa, Perbet, Romain, Donahue, Cameron, Commins, Caitlin, Quittot, Noé, Fan, Zhanyun, Bennett, Rachel E., Hyman, Bradley T.“…RESULTS: We performed the rational design of novel tau probes based on the current structural knowledge of pathological tau aggregates in Alzheimer’s disease. …”
Publicado 2023
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1965por Lorenzini, Theo, Cadilha, Bruno L., Obeck, Hannah, Benmebarek, Mohamed-Reda, Märkl, Florian, Michaelides, Stefanos, Strzalkowski, Thaddäus, Briukhovetska, Daria, Müller, Philipp Jie, Nandi, Sayantan, Winter, Pia, Majed, Lina, Grünmeier, Ruth, Seifert, Matthias, Rausch, Svenja, Feuchtinger, Tobias, Endres, Stefan, Kobold, SebastianEnlace del recurso
Publicado 2023
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1966por Joynt, G M, Gopalan, P D, Argent, A, Chetty, S, Wise, R, Lai, V K W, Hodgson, E, Lee, A, Joubert, I, Mokgokong, S, Tshukutsoane, S, Richards, G A, Menezes, C, Mathivha, L R, Espen, B, Levy, B, Asante, K, Paruk, F“…Critically limited resources necessitate that rationing and triage (prioritisation) decisions are routinely necessary in SA, particularly in the publicly funded health sector. …”
Publicado 2019
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1967por Joynt, G M, Gopalan, P D, Argent, A, Chetty, S, Wise, R, Lai, V K W, Hodgson, E, Lee, A, Joubert, I, Mokgokong, S, Tshukutsoane, S, Richards, G A, Menezes, C, Mathivha, L R, Espen, B, Levy, B, Asante, K, Paruk, F“…Critically limited resources necessitate that rationing and triage (prioritisation) decisions are frequently necessary in SA, particularly in the publicly funded health sector. …”
Publicado 2019
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1968por Ren, Shiwei, Ding, Yubing, Zhang, Wenqing, Wang, Zhuoer, Wang, Sichun, Yi, Zhengran“…Organic polymer semiconductor materials, due to their good chemical modifiability, can be easily tuned by rational molecular structure design to modulate their material properties, which, in turn, affects the device performance. …”
Publicado 2023
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1969por Aldea, M., Friboulet, L., Apcher, S., Jaulin, F., Mosele, F., Sourisseau, T., Soria, J.-C., Nikolaev, S., André, F.Enlace del recurso
Publicado 2023
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1970por Nabidda, Shamim, Ssennyonjo, Rogers, Atwaru, Joseph, Kanyike, Andrew Marvin, Baryayaka, Shiellah, Pangholi, Kennedy, Tusiimire, Jonans“…Their high confidence in rational prescription practices should be pivotal to the fight against AMR.…”
Publicado 2023
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1971
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1972“…In this study, iolS, an aldo–keto reductase from Bacillus subtilis 168 was exhibited as a potential biocatalyst, which could catalyze the reduction of diaryl α-keto amide such as 2-oxo-N, 2-diphenyl-acetamide (ONDPA) with moderate S-selectivity (76.1%, ee) and 60.5% conversion. Through semi-rational engineering, two stereocomplementary variants (I57F/F126L and N21A/F126A) were obtained with ee value of 97.6% (S) and 99.9% (R) toward ONDPA (1a), respectively, delivering chiral α-hydroxy amide with > 98% conversions. …”
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1973por Tan, Asako, Murugapiran, Senthil, Mikalauskas, Alaya, Koble, Jeff, Kennedy, Drew, Hyde, Fred, Ruotti, Victor, Law, Emily, Jensen, Jordan, Schroth, Gary P., Macklaim, Jean M., Kuersten, Scott, LeFrançois, Brice, Gohl, Daryl M.Enlace del recurso
Publicado 2023
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1974por Chukwuma, Joseph Nnaemeka, Areji, Anthony Chukwudi, Obumse, Nneka Anthonia, Eze, Emmanuel, Amadi, Kingsley, Agbo, Christian Onuorah, Nweze, Celestina Adaeze, Eze, Chima Fidelis, Omeh, Samuel O., Elom, Chinyere O., Ari, Abubakar Omame, Obeagu, Emmanuel Ifeanyi, Omeje, Grace Ngozi“…Using this reason, we tested the impact of exposure to rational career reflective training on work-related ethics among student-philosophers. …”
Publicado 2023
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1975por Tang, Qi, Fakih, Hassan H., Zain UI Abideen, Mohammad, Hildebrand, Samuel R., Afshari, Khashayar, Gross, Katherine Y., Sousa, Jacquelyn, Maebius, Allison S., Bartholdy, Christina, Søgaard, Pia Pernille, Jackerott, Malene, Hariharan, Vignesh, Summers, Ashley, Fan, Xueli, Okamura, Ken, Monopoli, Kathryn R., Cooper, David A., Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Furgal, Raymond C., Dresser, Karen, Winter, Sarah J., Biscans, Annabelle, Chuprin, Jane, Haddadi, Nazgol-Sadat, Sherman, Shany, Yıldız-Altay, Ümmügülsüm, Rashighi, Mehdi, Richmond, Jillian M., Bouix-Peter, Claire, Blanchard, Carine, Clauss, Adam, Alterman, Julia F., Khvorova, Anastasia, Harris, John E.“…Absolute JAK subtype selectivity has not yet been achieved. Here, we rationally design small interfering RNAs (siRNAs) that offer sequence-specific gene silencing of JAK1, narrowing the spectrum of action on JAK-dependent cytokine signaling to maintain efficacy and improve safety. …”
Publicado 2023
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1976por Honda, Kenya, Furuichi, Munehiro, Kawaguchi, Takaaki, Pust, Marie-Madlen, Yasuma-Mitobe, Keiko, Plichta, Damian, Hasegawa, Naomi, Ohya, Takashi, Bhattarai, Shakti, Sasajima, Satoshi, Yoshimasa, Aoto, Tuganbaev, Timur, Yaginuma, Mizuki, Ueda, Masahiro, Okahashi, Nobuyuki, Amafuji, Kimiko, Kiridooshi, Yuuko, Sugita, Kayoko, Stražar, Martin, Skelly, Ashwin, Suda, Wataru, Hattori, Masahira, Nakamoto, Nobuhiro, Caballero, Silvia, Norman, Jason, Olle, Bernat, Tanoue, Takeshi, Arita, Makoto, Bucci, Vanni, Atarashi, Koji, Xavier, Ramnik“…Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment(3,4), though an emerging body of evidence suggests that manipulation of the commensal microbiota may be a practical alternative therapeutic strategy(5–7). In this study, we rationally isolated and down-selected commensal bacterial consortia from healthy human stool samples capable of strongly and specifically suppressing intestinal Enterobacteriaceae. …”
Publicado 2023
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1977Tuning the Growth of Chiral Gold Nanoparticles Through Rational Design of a Chiral Molecular Inducerpor Van Gordon, Kyle, Baúlde, Sandra, Mychinko, Mikhail, Heyvaert, Wouter, Obelleiro-Liz, Manuel, Criado, Alejandro, Bals, Sara, Liz-Marzán, Luis M., Mosquera, JesúsEnlace del recurso
Publicado 2023
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1978“…Therefore, this work suggests a simple and rational approach to design small, hydrophilic, and conjugatable NIR fluorophores for targeted bioimaging.…”
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1979por Londono-Ruiz, Juan Pablo, Lombo, Julian Enrique Avila, Losada, Maria Alejandra Medina, Gutierrez-Tobar, Ivan Felipe, Rodriguez-hernandez, Andrea Esperanza“…The implementation of an Antimicrobial Stewardship (ASP) strategy directed at this antibiotic and its rational use allows for reductions in its unnecessary consumption. …”
Publicado 2023
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1980“…RESULTS: Four major concerns appeared in the group discussions: The obligation to ration health care, professional autonomy, patient autonomy, and competition. …”
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