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  1. 118601
    “…Twenty-five potential elements of the history, 24 symptoms, 41 physical signs, 21 investigative tools, and 26 overarching diagnostic criteria, were identified and coded as counts of recommendation per condition, alongside qualitative analysis of the clinical reasoning. Condition definitions were constructed with 11 standardised elements based on recent consensus exercises for other conditions. …”
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    Developing a diagnostic framework for patients presenting with Exercise Induced Leg Pain (EILP): a scoping review
  2. 118602
    “…The retention rate was 90.8%, 76.8% and 71.4% at 3, 6 and 12 months. The main reasons for treatment discontinuation were lack of effectiveness (21.1%) and inadequate tolerability (6.6%). …”
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    Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
  3. 118603
    “…One of the reasons for the high efficiency and selectivity of biological catalysts arise from their ability to control the pathways of substrates and products using protein channels, and by modulating the transport in the channels using the interaction with the protein residues and the water/hydrogen-bonding network. …”
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    Evolutionary diversity of proton and water channels on the oxidizing side of photosystem II and their relevance to function
  4. 118604
    por Ley, Timothy J, Mardis, Elaine R, Ding, Li, Fulton, Bob, McLellan, Michael D, Chen, Ken, Dooling, David, Dunford-Shore, Brian H, McGrath, Sean, Hickenbotham, Matthew, Cook, Lisa, Abbott, Rachel, Larson, David E, Koboldt, Dan C, Pohl, Craig, Smith, Scott, Hawkins, Amy, Abbott, Scott, Locke, Devin, Hillier, LaDeana W, Miner, Tracie, Fulton, Lucinda, Magrini, Vincent, Wylie, Todd, Glasscock, Jarret, Conyers, Joshua, Sander, Nathan, Shi, Xiaoqi, Osborne, John R, Minx, Patrick, Gordon, David, Chinwalla, Asif, Zhao, Yu, Ries, Rhonda E, Payton, Jacqueline E, Westervelt, Peter, Tomasson, Michael H, Watson, Mark, Baty, Jack, Ivanovich, Jennifer, Heath, Sharon, Shannon, William D, Nagarajan, Rakesh, Walter, Matthew J, Link, Daniel C, Graubert, Timothy A, DiPersio, John F, Wilson, Richard K
    Publicado 2008
    “…Whole genome sequencing is now possible at a reasonable cost and timeframe to utilize this approach for unbiased discovery of tumor-specific somatic mutations that alter the protein-coding genes. …”
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    DNA sequencing of a cytogenetically normal acute myeloid leukemia genome
  5. 118605
    por Ritte, Rebecca, Lukanova, Annekatrin, Berrino, Franco, Dossus, Laure, Tjønneland, Anne, Olsen, Anja, Overvad, Thure Filskov, Overvad, Kim, Clavel-Chapelon, Françoise, Fournier, Agnès, Fagherazzi, Guy, Rohrmann, Sabine, Teucher, Birgit, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Quirós, José Ramón, Buckland, Genevieve, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Sund, Malin, Lenner, Per, Bueno-de-Mesquita, Bas, van Gils, Carla H, Peeters, Petra HM, Krum-Hansen, Sanda, Gram, Inger Torhild, Lund, Eiliv, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Key, Timothy J, Romieu, Isabelle, Rinaldi, Sabina, Siddiq, Afshan, Cox, David, Riboli, Elio, Kaaks, Rudolf
    Publicado 2012
    “…INTRODUCTION: Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with hormone-receptor negative malignancies, and possible interactions by hormone replacement therapy (HRT) use. …”
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    Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
  6. 118606
    por Guo, Yan, Warren Andersen, Shaneda, Shu, Xiao-Ou, Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Garcia-Closas, Montserrat, Milne, Roger L., Schmidt, Marjanka K., Chang-Claude, Jenny, Dunning, Allison, Bojesen, Stig E., Ahsan, Habibul, Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bogdanova, Natalia V., Bonanni, Bernardo, Børresen-Dale, Anne-Lise, Brand, Judith, Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Burwinkel, Barbara, Casey, Graham, Chenevix-Trench, Georgia, Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Dumont, Martine, Fasching, Peter A., Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Fostira, Florentia, Gammon, Marilie, Giles, Graham G., Guénel, Pascal, Haiman, Christopher A., Hamann, Ute, Hooning, Maartje J., Hopper, John L., Jakubowska, Anna, Jasmine, Farzana, Jenkins, Mark, John, Esther M., Johnson, Nichola, Jones, Michael E., Kabisch, Maria, Kibriya, Muhammad, Knight, Julia A., Koppert, Linetta B., Kosma, Veli-Matti, Kristensen, Vessela, Le Marchand, Loic, Lee, Eunjung, Li, Jingmei, Lindblom, Annika, Luben, Robert, Lubinski, Jan, Malone, Kathi E., Mannermaa, Arto, Margolin, Sara, Marme, Frederik, McLean, Catriona, Meijers-Heijboer, Hanne, Meindl, Alfons, Neuhausen, Susan L., Nevanlinna, Heli, Neven, Patrick, Olson, Janet E., Perez, Jose I. A., Perkins, Barbara, Peterlongo, Paolo, Phillips, Kelly-Anne, Pylkäs, Katri, Rudolph, Anja, Santella, Regina, Sawyer, Elinor J., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shrubsole, Martha J., Southey, Melissa C., Swerdlow, Anthony J., Toland, Amanda E., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Ursin, Giske, Van Der Luijt, Rob B., Verhoef, Senno, Whittemore, Alice S., Winqvist, Robert, Zhao, Hui, Zhao, Shilin, Hall, Per, Simard, Jacques, Kraft, Peter, Pharoah, Paul, Hunter, David, Easton, Douglas F., Zheng, Wei
    Publicado 2016
    “…The reduced risk of postmenopausal breast cancer associated with genetically predicted BMI observed in this study differs from the positive association reported from studies using measured adult BMI. Understanding the reasons for this discrepancy may reveal insights into the complex relationship of genetic determinants of body weight in the etiology of breast cancer.…”
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    Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
  7. 118607
    por Cote, Ila, Andersen, Melvin E., Ankley, Gerald T., Barone, Stanley, Birnbaum, Linda S., Boekelheide, Kim, Bois, Frederic Y., Burgoon, Lyle D., Chiu, Weihsueh A., Crawford-Brown, Douglas, Crofton, Kevin M., DeVito, Michael, Devlin, Robert B., Edwards, Stephen W., Guyton, Kathryn Z., Hattis, Dale, Judson, Richard S., Knight, Derek, Krewski, Daniel, Lambert, Jason, Maull, Elizabeth Anne, Mendrick, Donna, Paoli, Gregory M., Patel, Chirag Jagdish, Perkins, Edward J., Poje, Gerald, Portier, Christopher J., Rusyn, Ivan, Schulte, Paul A., Simeonov, Anton, Smith, Martyn T., Thayer, Kristina A., Thomas, Russell S., Thomas, Reuben, Tice, Raymond R., Vandenberg, John J., Villeneuve, Daniel L., Wesselkamper, Scott, Whelan, Maurice, Whittaker, Christine, White, Ronald, Xia, Menghang, Yauk, Carole, Zeise, Lauren, Zhao, Jay, DeWoskin, Robert S.
    Publicado 2016
    “…CONCLUSIONS: While considerable uncertainties remain, thoughtful application of new knowledge to risk assessment appears reasonable for augmenting major scope assessments, forming the basis for or augmenting limited scope assessments, and for prioritization and screening of very data limited chemicals. …”
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    The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions
  8. 118608
    “…Of these, 67 (89%) reported current health insurance coverage, 59 (79%) had ever been prescribed and 45 (60%) were currently taking HIV medications, 59 (79%) had seen an HIV provider in the past year, and 34 (45%) had missed an HIV appointment in the past year. Reasons for not seeing a provider included feeling healthy, using alcohol or drugs, not having enough money or health insurance, and not wanting to take HIV medicines. …”
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    The RSVP Project: Factors Related to Disengagement From Human Immunodeficiency Virus Care Among Persons in San Francisco
  9. 118609
    “…Possible explanations may involve characteristics of the website itself, its use by participants, or methodological reasons. Future studies aimed at evaluating potential effects of websites providing patient experiences on the basis of methodological principles such as those of DIPEx might profit from extending the range of outcome measures, from including additional measures of website usage behavior and users’ motivation, and from expanding concepts, such as patient competency to include items that more directly reflect patients’ perceived effects of using such a website. …”
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    Effect of a Website That Presents Patients’ Experiences on Self-Efficacy and Patient Competence of Colorectal Cancer Patients: Web-Based Randomized Controlled Trial
  10. 118610
    por Crow, Rebecca A., Hart, Kimberly A., McDermott, Michael P., Tawil, Rabi, Martens, William B., Herr, Barbara E., McColl, Elaine, Wilkinson, Jennifer, Kirschner, Janbernd, King, Wendy M., Eagle, Michele, Brown, Mary W., Hirtz, Deborah, Lochmuller, Hanns, Straub, Volker, Ciafaloni, Emma, Shieh, Perry B., Spinty, Stefan, Childs, Anne-Marie, Manzur, Adnan Y., Morandi, Lucia, Butterfield, Russell J., Horrocks, Iain, Roper, Helen, Flanigan, Kevin M., Kuntz, Nancy L., Mah, Jean K., Morrison, Leslie, Darras, Basil T., von der Hagen, Maja, Schara, Ulrike, Wilichowski, Ekkehard, Mongini, Tiziana, McDonald, Craig M., Vita, Giuseppe, Barohn, Richard J., Finkel, Richard S., Wicklund, Matthew, McMillan, Hugh J., Hughes, Imelda, Pegoraro, Elena, Bryan Burnette, W., Howard, James F., Thangarajh, Mathula, Campbell, Craig, Griggs, Robert C., Bushby, Kate, Guglieri, Michela
    Publicado 2018
    “…RESULTS: Time from the first contact to site activation across countries ranged from 6 to 24 months. Reasons of delay were universal (sponsor agreement, drug procurement, budgetary constraints), country specific (complexity and diversity of regulatory processes, indemnity requirements) and site specific (contracting and approvals). …”
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    A checklist for clinical trials in rare disease: obstacles and anticipatory actions—lessons learned from the FOR-DMD trial
  11. 118611
    “…After 6 years of trial participation (2 years in CLIPPER and 4 years in CLIPPER2), 41 (32%) patients were still taking ETN, 13 (11%) entered the treatment withdrawal phase after achieving low/inactive disease (of whom 7 had to restart ETN), 36 (28%) discontinued treatment for other reasons but are still being observed, and 37 (29%) discontinued treatment permanently. …”
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    Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial
  12. 118612
    “…Given that the ‘oldest-old’ are at greatest risk for LATE-NC, and subjects of advanced age constitute a rapidly growing demographic group in many countries, LATE has an expanding but under-recognized impact on public health. For these reasons, a working group was convened to develop diagnostic criteria for LATE, aiming both to stimulate research and to promote awareness of this pathway to dementia. …”
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    Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
  13. 118613
    “…The multivariate linear discriminant analysis showed there was a reasonable difference in results between the control and HAM/TSP groups, and the HTLV-1 group was at the intersecting area between them. …”
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    Balance Impairments in Patients with Human T-Cell Lymphotropic Virus Type 1 Infection
  14. 118614
    “…Purpose: Serum IGF-1 (Insulin like growth factor 1) and Growth Hormone (GH) provocative tests are reasonable tools for screening and diagnosis of idiopathic GH Deficiency (IGHD). …”
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    Diagnosis of Idiopathic GHD in Children Based on Response to rhGH Treatment: The Importance of GH Provocative Tests and IGF-1
  15. 118615
    “…It may provide a pathway into treatment for people who may otherwise be disengaged with health services for a range of reasons and will be a culturally appropriate, evidence-based resource for health practitioners to offer their clients. …”
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    A Web-Based Therapeutic Program (We Can Do This) for Reducing Methamphetamine Use and Increasing Help-Seeking Among Aboriginal and Torres Strait Islander People: Protocol for a Randomized Wait-List Controlled Trial
  16. 118616
    “…Tailoring of plans is achieved by using case-based reasoning (CBR) methodology, which is a branch of artificial intelligence. …”
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    An App-Delivered Self-Management Program for People With Low Back Pain: Protocol for the selfBACK Randomized Controlled Trial
  17. 118617
    “…Personalization of the T-DM1+P regimen could serve as a reasonable approach to minimize toxicity while maintaining efficacy. …”
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    A randomized, 3-arm, neoadjuvant, phase 2 study comparing docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP), TCbHP followed by trastuzumab emtansine and pertuzumab (T-DM1+P), and T-DM1+P in HER2-positive primary breast cancer
  18. 118618
    “…RESULTS: A total of 17 participants were screened, 15 were randomised and 11 completed the study (n = 9 serelaxin, n = 2 placebo). Reasons for withdrawal were baseline HVPG < 10 mmHg (n = 2) and technical failure (n = 2). …”
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    A phase 2 randomised controlled trial of serelaxin to lower portal pressure in cirrhosis (STOPP)
  19. 118619
    “…Pre-school age children (PSAC) have been neglected both in terms of research activities and in control programmes in the past for reasons that they carry insignificant infection levels. …”
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    Soil-transmitted helminths and schistosomiasis among pre-school age children in a rural setting of Busia County, Western Kenya: a cross-sectional study of prevalence, and associated exposures
  20. 118620
    “…This study provided a reasonable approach to extensively retrieve and initially validate putative therapeutic agents for PAAD. …”
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    The potential drug for treatment in pancreatic adenocarcinoma: a bioinformatical study based on distinct drug databases
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