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119701por Gu, Tian, Mack, Jasmine A., Salvatore, Maxwell, Prabhu Sankar, Swaraaj, Valley, Thomas S., Singh, Karandeep, Nallamothu, Brahmajee K., Kheterpal, Sachin, Lisabeth, Lynda, Fritsche, Lars G., Mukherjee, Bhramar“…IMPORTANCE: Black patients are overrepresented in the number of COVID-19 infections, hospitalizations, and deaths in the US. Reasons for this disparity may be due to underlying comorbidities or sociodemographic factors that require further exploration. …”
Publicado 2020
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119702por Colombo, G E, Leonardi, M, Armour, M, Di Somma, H, Dinh, T, da Silva Costa, F, Wong, L, Armour, S, Condous, G“…Compared with EM, there was insufficient evidence that methotrexate yields a difference on resolution of tubal EP (RR 1.04, 95% CI 0.88–1.23, P = 0.67; two RCTs, moderate-certainty evidence), avoiding surgery (RR 1.10, 95% CI 0.94–1.29, P = 0.25; two RCTs, low-certainty evidence) or the time to resolution of tubal EP (−2.56 days (favouring EM), 95% CI −7.93–2.80, P = 0.35; two RCTs, low-certainty evidence). LIMITATIONS, REASONS FOR CAUTION: Only two RCTs with a total of 103 patients were eligible for inclusion in this meta-analysis. …”
Publicado 2020
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119703por Joseph, Treasa, Mascarenhas, Mariano, Karuppusami, Reka, Karthikeyan, Muthukumar, Kunjummen, Aleyamma T, Kamath, Mohan S“…The semen parameters of sperm concentration (median, interquartile range, IQR) (18.2, 8.6 to 37.5 vs 20.5, 8.0 to 52.5, million/ml; P = 0.97), motility (median, IQR) (34, 20 to 45 vs 31, 18 to 45%; P = 0.38) and morphology (mean ± SD) (2.0 ± 1.4 vs 2.2 ± 1.5%; P = 0.69) did not show any significant improvement after intake of antioxidant compared to no treatment, respectively. LIMITATIONS, REASONS FOR CAUTION: The objective assessment of sperm DNA damage was not carried out before and after the antioxidant pretreatment. …”
Publicado 2020
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119704“…Subsequent antral follicle development could not be observed. LIMITATIONS, REASONS FOR CAUTION: A limitation is the small sample size, inherent to this study subject, especially as a large amount of tissue was needed per patient to reduce inter-patient variation in different downstream analysis techniques. …”
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119705por Ibarra-Estrada, Miguel Á., Marín-Rosales, Miguel, García-Salcido, Roxana, Aguirre-Díaz, Sara A., Vargas-Obieta, Alexandra, Chávez-Peña, Quetzalcóatl, López-Pulgarín, José A., Mijangos-Méndez, Julio C., Aguirre-Avalos, Guadalupe“…BLINDING (MASKING): Due to logistical reasons, only principal investigators and the data analyst will be blinded to group assignment. …”
Publicado 2020
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119706por Duffy, J M N, Bhattacharya, S, Bhattacharya, S, Bofill, M, Collura, B, Curtis, C, Evers, J L H, Giudice, L C, Farquharson, R G, Franik, S, Hickey, M, Hull, M L, Jordan, V, Khalaf, Y, Legro, R S, Lensen, S, Mavrelos, D, Mol, B W, Niederberger, C, Ng, E H Y, Puscasiu, L, Repping, S, Sarris, I, Showell, M, Strandell, A, Vail, A, van Wely, M, Vercoe, M, Vuong, N L, Wang, A Y, Wang, R, Wilkinson, J, Youssef, M A, Farquhar, C M“…Specific recommendations were made to improve reporting. LIMITATIONS, REASONS FOR CAUTION: We used consensus development methods, which have inherent limitations. …”
Publicado 2020
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119707por Grzegorczyk-Martin, V, Fréour, T, De Bantel Finet, A, Bonnet, E, Merzouk, M, Roset, J, Roger, V, Cédrin-Durnerin, I, Wainer, R, Avril, C, Landais, P“…In operated women, a significantly smaller weight for gestational age was observed in newborns of Group 1 compared to Group 3 (P = 0.04). LIMITATIONS, REASONS FOR CAUTION: This study was conducted in France and nearly all patients were Caucasian, questioning the generalizability of the results in other countries and ethnicities. …”
Publicado 2020
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119708“…The role of chance is likely to be small in this study given the large sample sizes available. LIMITATIONS, REASONS FOR CAUTION: Participants included in our analyses were more socially advantaged than those excluded. …”
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119709por Duffy, J M N, AlAhwany, H, Bhattacharya, S, Collura, B, Curtis, C, Evers, J L H, Farquharson, R G, Franik, S, Giudice, L C, Khalaf, Y, Knijnenburg, J M L, Leeners, B, Legro, R S, Lensen, S, Vazquez-Niebla, J C, Mavrelos, D, Mol, B W J, Niederberger, C, Ng, E H Y, Otter, A S, Puscasiu, L, Rautakallio-Hokkanen, S, Repping, S, Sarris, I, Simpson, J L, Strandell, A, Strawbridge, C, Torrance, H L, Vail, A, van Wely, M, Vercoe, M A, Vuong, N L, Wang, A Y, Wang, R, Wilkinson, J, Youssef, M A, Farquhar, C M“…Time to pregnancy leading to live birth should be reported when applicable. LIMITATIONS, REASONS FOR CAUTION: We used consensus development methods which have inherent limitations, including the representativeness of the participant sample, Delphi survey attrition and an arbitrary consensus threshold. …”
Publicado 2020
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119710por De Geyter, Ch, Wyns, C, Calhaz-Jorge, C, de Mouzon, J, Ferraretti, A P, Kupka, M, Nyboe Andersen, A, Nygren, K G, Goossens, V“…Some adverse events, such as maternal death, ovarian hyperstimulation syndrome, haemorrhage and infections, were only recorded by EIM and ANZARD. LIMITATIONS, REASONS FOR CAUTION: The methods of data collection and reporting were very different among European countries, but also among the three registers. …”
Publicado 2020
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119711por D'Amico, Ronald, Benn, Paul, McCoig, Cynthia C, McCoig, Cynthia C, Griffith, Sandy, Hudson, Krischan J, Sutton, Kenneth, Sutton, Kenneth, Harrington, Conn M, Wu, Sterling, Williams, Will, Hove, Kai S, Martin Espanol, Carlos, Fricker, E Jane, Patel, Parul, Margolis, David, Margolis, David“…LA dosing was interrupted in 51 (45%) participants due to clinic closure or staffing constraints, 9 (8%) for self-quarantine, 11 (10%) for confirmed or suspected COVID-19, and 42 (37%) for other reasons. Among participants impacted, 64 (58%) were from N. …”
Publicado 2020
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119712por Baldi, Enrico, Schnaubelt, Sebastian, Caputo, Maria Luce, Klersy, Catherine, Clodi, Christian, Bruno, Jolie, Compagnoni, Sara, Benvenuti, Claudio, Domanovits, Hans, Burkart, Roman, Fracchia, Rosa, Primi, Roberto, Ruzicka, Gerhard, Holzer, Michael, Auricchio, Angelo, Savastano, Simone“…CONCLUSIONS AND RELEVANCE: This study suggests that early ECG acquisition after ROSC in patients with OHCA is associated with a higher percentage of false-positive ECG findings for STEMI. It may be reasonable to delay post-ROSC ECG by at least 8 minutes after ROSC or repeat the acquisition if the first ECG is diagnostic of STEMI and is acquired early after ROSC.…”
Publicado 2021
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119713por Onogi, Sachie, Ezoe, Kenji, Nishihara, Seiko, Fukuda, Junichiro, Kobayashi, Tamotsu, Kato, Keiichi“…A decreased EMT on day of the LH surge was significantly associated with greater female age (P = 0.0003) and a shortened follicular/proliferation phase (P < 0.0001). LIMITATIONS, REASONS FOR CAUTION: The data used in this study were obtained from a single-centre cohort; therefore, multi-centre studies are required to ascertain the generalisability of these findings to other clinics with different protocols and/or patient demographics. …”
Publicado 2020
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119714por Roman, H, Merlot, B, Forestier, D, Noailles, M, Magne, E, Carteret, T, Tuech, J-J, Martin, D C“…Lesions as small as 2 mm were palpable. LIMITATIONS, REASONS FOR CAUTION: This is an observational study. …”
Publicado 2021
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119715por Richmond, Peter, Hatchuel, Lara, Dong, Min, Ma, Brenda, Hu, Branda, Smolenov, Igor, Li, Ping, Liang, Peng, Han, Htay Htay, Liang, Joshua, Clemens, Ralf“…FINDINGS: Between June 19 and Sept 23, 2020, 151 volunteers were enrolled; three people withdrew, two for personal reasons and one with an unrelated serious adverse event (pituitary adenoma). 148 participants had at least 4 weeks of follow-up after dose two and were included in this analysis (database lock, Oct 23, 2020). …”
Publicado 2021
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119716por van der Kooi, Anne-Lotte L F, van Dijk, Marloes, Broer, Linda, van den Berg, Marleen H, Laven, Joop S E, van Leeuwen, Flora E, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, van der Pal, Helena J, Tissing, Wim J, Versluys, Birgitta, Bresters, Dorine, Beerendonk, Catharina C M, Ronckers, Cécile R, van der Heiden-van der Loo, Margriet, Kaspers, Gertjan L, de Vries, Andrica C H, Robison, Leslie L, Hudson, Melissa M, Chemaitilly, Wassim, Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D, Grabow, Desiree, Haupt, Riccardo, Kaiser, Melanie, Kepak, Tomas, Kruseova, Jarmila, Modan-Moses, Dalit, Pluijm, Saskia M F, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H, Kremer, Leontien C, Yasui, Yutaka, Brooke, Russell J, Uitterlinden, André G, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline“…MAIN RESULTS AND THE ROLE OF CHANCE: Meta-analysis across the three independent cohorts showed a significant interaction effect (P = 3.0 × 10(−4)) between rs11668344 of BRSK1 (allele frequency = 0.34) among CCS treated with high-dose alkylating agents (CED score ≥8000 mg/m(2)), resulting in a 2.5-fold increased odds of a reduced ovarian function (lowest AMH tertile) for CCS carrying one G allele compared to CCS without this allele (odds ratio genotype AA: 2.01 vs AG: 5.00). LIMITATIONS, REASONS FOR CAUTION: While low AMH levels can also identify poor responders in assisted reproductive technology, it needs to be emphasized that AMH remains a surrogate marker of ovarian function. …”
Publicado 2021
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119717por Ye, Zhikang, Wang, Ying, Ge, Long, Guyatt, Gordon H., Collister, David, Alhazzani, Waleed, Bagshaw, Sean M., Belley-Cote, Emilie P., Fang, Fang, Hou, Liangying, Kolb, Philipp, Lamontagne, Francois, Oczkowski, Simon, Pyne, Lonnie, Rabbat, Christian, Scaum, Matt, Najafabadi, Borna Tadayon, Tangamornsuksan, Wimonchat, Wald, Ron, Wang, Qi, Walsh, Michael, Yao, Liang, Zeng, Linan, Algarni, Abdullah Mohammed, Couban, Rachel J., Alexander, Paul Elias, Rochwerg, Bram“…At the very least, ICU clinicians should feel comfortable that the differences between continuous renal replacement therapy, intermittent hemodialysis, slow efficiency extended dialysis, and, where clinically appropriate, peritoneal dialysis are likely small, and any of these modalities is a reasonable option to employ in critically ill patients.…”
Publicado 2021
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119718por Fuchs Weizman, Noga, Wyse, Brandon A, Szaraz, Peter, Defer, Miranda, Jahangiri, Sahar, Librach, Clifford L“…LARGE SCALE DATA: N/A. LIMITATIONS, REASONS FOR CAUTION: Our study is limited by lack of details regarding mode, frequency and timing of PC consumption. …”
Publicado 2021
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119719por Velez, M P, Richardson, H, Baxter, N N, McClintock, Chad, Greenblatt, E, Barr, R, Green, M“…In survivors of brain or colorectal cancer, the association was not significant, overall or after stratification by parity. LIMITATIONS, REASONS FOR CAUTION: Non-biological factors that may influence the likelihood of seeking a fertility assessment may not be captured in administrative databases. …”
Publicado 2021
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119720por Manolea, Corina, Capitanescu, Andrei, Borș, Roxana, Rugescu, Ioana, Bechir, Melihan, Mehedintu, Claudia, Varlas, Valentin“…The study was undertaken in a high-risk area for COVID-19, with a 20-times increase in the active cases across the study period. LIMITATIONS, REASONS FOR CAUTION: The geographical restriction, alongside the lack of running a second, differently-targeted immunoassay (orthogonal testing), could limit the generalizability and translation of our results to other fertility settings or other immunoassays. …”
Publicado 2021
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