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119721por Kakuhikire, Bernard, Satinsky, Emily N., Baguma, Charles, Rasmussen, Justin D., Perkins, Jessica M., Gumisiriza, Patrick, Juliet, Mercy, Ayebare, Patience, Mushavi, Rumbidzai C., Burns, Bridget F. O., Evans, Claire Q., Siedner, Mark J., Bangsberg, David R., Tsai, Alexander C.“…Study limitations include lack of detailed data on reasons for attendance/nonattendance at community sensitization meetings; achieving a representative sample of community members was not an explicit aim of the study; and generalizability may not extend beyond this study setting. …”
Publicado 2021
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119722por Goshua, George, Liu, Yiwen, Meizlish, Matthew L., Fine, Rebecca, Amin, Kejal, Chang, Eric, Liu, Yuxin, McManus, Dayna, Petrosan, Adina, Ochoa Chaar, Cassius Ilya, Chun, Hyung J., Defilippo, Nicholas A., Neuberg, Donna S., Owusu, Kent A., Lee, Alfred Ian“…Endotheliopathy and activation of both platelets and coagulation predict critical illness and death. For these reasons the use of anti-platelet agents and increased-intensity anticoagulation in the care of hospitalized patients with COVID-19 is under intense study in several clinical trials. …”
Publicado 2020
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119723por Rosovsky, Rachel P., Endres, Paul, Zhao, Soophia H, Krinsky, Scott, Percy, Shananssa G, Kamal, Omer, Roberts, Russel J., Lopez, Natasha, Sise, Meghan E, Steele, David J, Lundquist, Andrew L, Rhee, Eugene P, Hibbert, Kathryn A, Hardin, Charles C, McCausland, Finnian R, Czarnecki, Peter G., Mutter, Walter P, Tolkoff-Rubin, Nina E, Allegretti, Andrew S“…An anticoagulation protocol using systemic unfractionated heparin, dosed by anti-factor Xa levels is a reasonable approach to anticoagulation in this population. …”
Publicado 2020
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119724por Wallis, Robert S, Ginindza, Sibuse, Beattie, Trevor, Arjun, Nishanee, Likoti, Morongwe, Edward, Vinodh A, Rassool, Mohammed, Ahmed, Khatija, Fielding, Katherine, Ahidjo, Bintou A, Vangu, Mboyo D T, Churchyard, Gavin“…INTERPRETATION: CC-11050 and everolimus were safe and reasonably well tolerated as adjunctive therapies for tuberculosis, and analysis of preliminary efficacy suggests they might also enhance the recovery of FEV(1), a key measure of lung function and predictor of all-cause mortality. …”
Publicado 2021
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119725por Oud, M S, Houston, B J, Volozonoka, L, Mastrorosa, F K, Holt, G S, Alobaidi, B K S, deVries, P F, Astuti, G, Ramos, L, Mclachlan, R I, O’Bryan, M K, Veltman, J A, Chemes, H E, Sheth, H“…LARGE SCALE DATA: N/A LIMITATIONS, REASONS FOR CAUTION: In this study, we described patients with either a homozygous or two heterozygous candidate pathogenic variants in genes linked to sperm motility disorders. …”
Publicado 2021
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119726por Espinoza-Pérez, José, Reyes, César, Hernández-Ruíz, Jesús, Díaz-Bautista, Maximino, Ramos-López, Francisco, Espinoza-Gómez, Abel, Pérez-García, Oscar“…Variables taken into account in the interview related to the consumption frequency of the species, its abundance and distribution perception, reasons or arguments given by the Totonac indigenous population about the decreased presence of specimens of S. aristolochiifolia, its dates of collection, and the cutting prices of kgentsililh at the community level and in local markets. …”
Publicado 2021
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119727“…The diagnosis unexplained infertility differed between groups, at 23.5% in group A and 32.2% in group B (P < 0.001). LIMITATIONS, REASONS FOR CAUTION: This was a historically controlled cohort study; introduction of bias cannot be ruled out. …”
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119728por Ahrenfeldt, L J, Möller, S, Wensink, M J, Eisenberg, M L, Christensen, K, Jensen, T K, Lindahl-Jacobsen, R“…Impaired fecundity was associated with a wide range of diseases and some causes of death, indicating a multi-factorial causal influence on fecundity, especially among women. LIMITATIONS, REASONS FOR CAUTION: A major limitation was that fecundity depends on both partners, which was not considered in this study. …”
Publicado 2021
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119729por Liu, Xiangliang, Ji, Wei, Zheng, Kaiwen, Lu, Jin, Li, Lingyu, Cui, Jiuwei, Li, Wei“…BACKGROUND: Studies have shown that the skeletal muscle index at the third lumbar vertebra (L3 SMI) had reasonable specificity and sensitivity in nutritional assessment and prognostic prediction in digestive system cancers, but its performance in lung cancer needs further investigation. …”
Publicado 2021
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119730por Hernáez, Álvaro, Rogne, Tormod, Skåra, Karoline H, Håberg, Siri E, Page, Christian M, Fraser, Abigail, Burgess, Stephen, Lawlor, Deborah A, Magnus, Maria Christine“…A genetically predicted BMI of 23 and 25 kg/m(2) was linked to the lowest subfertility risk in women and men, respectively. LIMITATIONS, REASONS FOR CAUTION: The main limitations of our study were that we did not know whether the subfertility was driven by the women, men or both; the exclusive consideration of individuals of northern European ancestry; and the limited amount of participants with obesity or BMI values <20.0 kg/m(2). …”
Publicado 2021
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119731por Dong, Ying, Huang, Herong, Deng, Yan, Xu, Yanchun, Chen, Mengni, Liu, Yan, Zhang, Canglin“…In order to understand the specific failure reasons for preventing vivax malaria relapses, a preliminary exploration on the CYP2D6 enzyme activity was carried out in the vivax malaria patients in Yunnan Province population by analysing mutational polymorphism in the coding region of CYP2D6 gene. …”
Publicado 2021
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119732por Karsten, M D A, Wekker, V, Groen, H, Painter, R C, Mol, B W J, Laan, E T M, Roseboom, T J, Hoek, A“…However, compared to an age-matched Dutch reference population, the obese infertile women with and without PCOS both scored lower on almost all physical and mental quality of life subscales. LIMITATIONS, REASONS FOR CAUTION: These are secondary analyses of the follow-up study of the RCT. …”
Publicado 2021
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119733“…However, all the above-mentioned arguments are just our speculation because, due to the urgency of the situation and technical reasons, we could not perform MRI of the orbit before the start of therapy. …”
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119734“…Both Grade B TE and Grade C TE blastocyst transfer had a higher chance of female baby (adjusted OR = 1.30 (1.11, 1.53), 1.88 (1.57, 2.26), respectively) and a lower risk of gestational diabetes mellitus (adjusted OR = 0.74 (0.59, 0.94), 0.67 (0.50, 0.88), respectively) than Grade A TE blastocyst transfer. LIMITATIONS, REASONS FOR CAUTION: The main limitations of this study were its retrospective nature and the relative subjectivity of blastocyst scoring. …”
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119735por Kamath, Mohan S, Joseph, Treasa, Karuppusami, Reka, Chinta, Parimala, Pal, Atri, Nallamilli, Sujatha Reddy, Sarkar, Sharmistha, Poobalan, Amudha, Kunjummen, Aleyamma T“…Further analysis revealed that participants’ education levels significantly influenced the desire to continue fertility treatment: participants with lower levels of education (below graduate) were less likely to continue fertility treatment (adjusted odds ratio 0.34, 95% CI, 0.12–0.98). LIMITATIONS, REASONS FOR CAUTION: Questionnaire-based responses could have limited the ability of the interviewer to capture the entire range of thoughts and views of the participants on the COVID pandemic and their fertility treatments. …”
Publicado 2021
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119736por Wright, Bill J, Tideman, Samuel, Diaz, George A, French, Thomas, Parsons, Guilford T, Robicsek, Ari“…Overall, 1293 (13·4%) of 9667 cases were fully vaccinated at the time of admission, compared with 22 308 (57·7%) of 38 668 controls, who were admitted to hospital for other reasons. The median time between vaccination and hospital admission among cases was 162 days (IQR 118–198). …”
Publicado 2022
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119737por Pega, Frank, Momen, Natalie C., Gagliardi, Diana, Bero, Lisa A., Boccuni, Fabio, Chartres, Nicholas, Descatha, Alexis, Dzhambov, Angel M., Godderis, Lode, Loney, Tom, Mandrioli, Daniele, Modenese, Alberto, van der Molen, Henk F., Morgan, Rebecca L., Neupane, Subas, Pachito, Daniela, Paulo, Marilia S., Prakash, K.C., Scheepers, Paul T.J., Teixeira, Liliane, Tenkate, Thomas, Woodruff, Tracey J., Norris, Susan L.“…In pilot tests, there was reasonable agreement in ratings for expected heterogeneity; 70% of raters selected the same rating. …”
Publicado 2022
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119738por Wen, Qidan, Hu, Min, Lai, Maohua, Li, Juan, Hu, Zhenxing, Quan, Kewei, Liu, Jia, Liu, Hua, Meng, Yanbing, Wang, Suling, Wen, Xiaohui, Yu, Chuyi, Li, Shuna, Huang, Shiya, Zheng, Yanhua, Lin, Han, Liang, Xingyan, Lu, Lingjing, Mai, Zhefen, Zhang, Chunren, Wu, Taixiang, Ng, Ernest H Y, Stener-Victorin, Elisabet, Ma, Hongxia“…Bruising was more common in the true acupuncture group (14.9%). LIMITATIONS, REASONS FOR CAUTION: This study might have underestimated the sample size in the true acupuncture group with 4 months of treatment to enable detection of statistically significant changes in HOMA-IR with fixed acupuncture (i.e. a non-personalized protocol). …”
Publicado 2021
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119739por von Grothusen, Carolina, Frisendahl, Caroline, Modhukur, Vijayachitra, Lalitkumar, Parameswaran Grace, Peters, Maire, Faridani, Omid R, Salumets, Andres, Boggavarapu, Nageswara Rao, Gemzell-Danielsson, Kristina“…LARGE SCALE DATA: The data are available in Gene Expression Omnibus (GEO) at https://www.ncbi.nlm.nih.gov/geo/ with GEO accession number: GSE173289. LIMITATIONS, REASONS FOR CAUTION: This is a descriptive study with a limited number of study participants. …”
Publicado 2022
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119740por Lipecki, Julia, Mitchell, Andrew E, Muter, Joanne, Lucas, Emma S, Makwana, Komal, Fishwick, Katherine, Odendaal, Joshua, Hawkes, Amelia, Vrljicak, Pavle, Brosens, Jan J, Ott, Sascha“…The RNA-sequencing data are available on GEO (accession GSE180485). LIMITATIONS, REASONS FOR CAUTION: Timing estimates are informed by glandular gene expression and will only represent the temporal state of other endometrial cell types if in synchrony with the epithelium. …”
Publicado 2022
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