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  1. 119841
    “…However, biomarkers and assays development to guide cancer immunotherapy is highly challenging for several reasons: (i) multiplicity of immunotherapy agents with different mechanisms of action including immunotherapies that target activating and inhibitory T cell receptors (e.g., CTLA-4, PD-1, etc.); adoptive T cell therapies that include tissue infiltrating lymphocytes (TILs), chimeric antigen receptors (CARs), and T cell receptor (TCR) modified T cells; (ii) tumor heterogeneity including changes in antigenic profiles over time and location in individual patient; and (iii) a variety of immune-suppressive mechanisms in the tumor microenvironment (TME) including T regulatory cells (Treg), myeloid derived suppressor cells (MDSC) and immunosuppressive cytokines. …”
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    Future perspectives in melanoma research: Meeting report from the “Melanoma Bridge”. Napoli, December 1st–4th 2015
  2. 119842
    por Mackenzie, Grant A, Hill, Philip C, Sahito, Shah M, Jeffries, David J, Hossain, Ilias, Bottomley, Christian, Uchendu, Uchendu, Ameh, David, Ndiaye, Malick, Osuorah, Chidebereh D, Adeyemi, Oyedeji, Pathirana, Jayani, Olatunji, Yekini, Abatan, Bade, Ahameefula, Ebirim, Muhammad, Bilquees S, Fombah, Augustin E, Saha, Debasish, Mackenzie, Roslyn, Plumb, Ian, Akano, Aliu, Ebruke, Bernard, Ideh, Readon C, Kuti, Bankole, Githua, Peter, Olutunde, Emmanuel, Ofordile, Ogochukwu, Green, Edward, Usuf, Effua, Badji, Henry, Ikumapayi, Usman N A, Manjang, Ahmad, Salaudeen, Rasheed, Nsekpong, E David, Jarju, Sheikh, Antonio, Martin, Sambou, Sana, Ceesay, Lamin, Lowe-Jallow, Yamundow, Sowe, Dawda, Jasseh, Momodou, Mulholland, Kim, Knoll, Maria, Levine, Orin S, Howie, Stephen R, Adegbola, Richard A, Greenwood, Brian M, Corrah, Tumani
    Publicado 2017
    “…Low-income countries that introduce PCV13 with reasonable coverage can expect modest reductions in hospitalised cases of pneumonia and a marked impact on the incidence of severe childhood pneumonia. …”
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    Impact of the introduction of pneumococcal conjugate vaccination on pneumonia in The Gambia: population-based surveillance and case-control studies
  3. 119843
    “…FINDINGS: Between September, 2015, and June, 2016, 376 infants were assessed for eligibility. 81 infants were excluded for not meeting the inclusion criteria (n=50) or for other reasons (n=31). 213 eligible infants were enrolled and randomly allocated to group 1 (n=106; 2 + 1 schedule) or to group 2 (n=107; 1 + 1 schedule). …”
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    Pneumococcal conjugate vaccine 13 delivered as one primary and one booster dose (1 + 1) compared with two primary doses and a booster (2 + 1) in UK infants: a multicentre, parallel group randomised controlled trial
  4. 119844
    “…LARGE SCALE DATA: Not applicable. LIMITATIONS REASONS FOR CAUTION: There are two main limitations for our study. …”
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    Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts
  5. 119845
    “…Key changes in this guideline include: (i) considerable refinement of individual diagnostic criteria with a focus on improving accuracy of diagnosis; (ii) reducing unnecessary testing; (iii) increasing focus on education, lifestyle modification, emotional wellbeing and quality of life; and (iv) emphasizing evidence based medical therapy and cheaper and safer fertility management. LIMITATIONS, REASONS FOR CAUTION: Overall evidence is generally low to moderate quality, requiring significantly greater research in this neglected, yet common condition, especially around refining specific diagnostic features in PCOS. …”
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    Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome(†)(‡)
  6. 119846
    “…Oral dydrogesterone was well tolerated and had a similar safety profile to MVP gel. LIMITATIONS, REASONS FOR CAUTION: The analysis of the results was powered to consider the ongoing pregnancy rate, but a primary objective of greater clinical interest may have been the live birth rate. …”
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    Oral dydrogesterone versus intravaginal micronized progesterone gel for luteal phase support in IVF: a randomized clinical trial
  7. 119847
    “…Through the analysis of the correlation between farmers with different social characteristics and their attitudes toward the cultivation, reasons for conservation and abandonment, development tendency, and protection of KSR, we found that a high level of education and female, young, and old farmers play more important role in the cultivation and protection of KSR. …”
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    Status and factors influencing on-farm conservation of Kam Sweet Rice (Oryza sativa L.) genetic resources in southeast Guizhou Province, China
  8. 119848
    “…LARGE-SCALE DATA: N/A. LIMITATIONS, REASONS FOR CAUTION: This study focuses on non-growing follicle activation after 6 days culture and may not reflect DNA damage and repair capacity in later stages of oocyte and follicle growth. …”
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    Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response
  9. 119849
    “…Neonatal congenital anomalies were observed in 1/46 (2.1%) of babies in the rhG-CSF group versus 1/49 (2.0%) in the placebo group (RR of 0.9; 95% CI: 0.1–13.4; P = 0.93). LIMITATIONS, REASONS FOR CAUTION: This trial was conducted in women diagnosed with unexplained recurrent pregnancy loss and therefore no screening tests (commercially available) were performed for immune dysfunction related pregnancy failure/s. …”
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    Recombinant human granulocyte– colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial
  10. 119850
    “…LARGE SCALE DATA: N/A. LIMITATIONS, REASONS FOR CAUTION: Although xenotransplantation of marmoset ITT was successful, it does not fully reflect all aspects of a future clinical setting. …”
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    Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate
  11. 119851
    “…The cumulative live birth rate per started cycle was similar (32 and 35%) comparing the individualized with the standard group. LIMITATIONS, REASONS FOR CAUTION: This study was powered for showing differences only in the distribution of oocyte retrieval when comparing individualized and standard groups, therefore additional results should be viewed with caution. …”
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    A randomized controlled trial of AMH-based individualized FSH dosing in a GnRH antagonist protocol for IVF
  12. 119852
    por Gameiro, S, Sousa-Leite, M, Vermeulen, N
    Publicado 2019
    “…Results for the clinicians only showed that, despite less knowledge about the RPC guideline, they were more likely to download all the guidelines, to follow them, make changes in their daily practice and refer them to their patients. LIMITATIONS, REASONS FOR CAUTION: Respondents were ESHRE members and these are not representative of all European reproductive health professionals. …”
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    Dissemination, implementation and impact of the ESHRE evidence-based guidelines
  13. 119853
    “…FINDINGS: Between May 22 and Aug 22, 2017, 48 volunteers were screened, of whom 15 (31%) volunteers were excluded for reasons relating to the inclusion or exclusion criteria, three (6%) volunteers were not treated because of restrictions to the number of participants in each group, and 30 (63%) volunteers were sequentially allocated to groups (15 participants per group). …”
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    The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 study
  14. 119854
    “…For two such patients we could phase the mutation to a nearby polymorphism (SNP) and determine that the mutation counts likely originated from a single or a small number of mutational events. LIMITATIONS, REASONS FOR CAUTION: This study was limited to 18 patients with different treatment regimens; for nine of the 18 patients, samples from only one timepoint were available. …”
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    The impact of chemo- and radiotherapy treatments on selfish de novo FGFR2 mutations in sperm of cancer survivors
  15. 119855
    “…In contrast, for women <24 years old, the likelihood of continuing PrEP for each additional year of a woman’s age was high in magnitude (approximately 6%) but statistically non-significant (adjusted PR: 1.06; 95% CI: 0.97–1.16; p = 0.18). Frequently reported reasons for discontinuing PrEP were low perceived risk of HIV (25%), knowledge that partner was HIV negative (24%), experiencing side effects (20%), and pill burden (17%). …”
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    Integrating preexposure prophylaxis delivery in routine family planning clinics: A feasibility programmatic evaluation in Kenya
  16. 119856
    por Graham, S, Freeman, T, Jadva, V
    Publicado 2019
    “…Online donors had more concerns about being a donor (p < 0.001), for example, being concerned about ‘legal uncertainty and child financial support’ and ‘future contact and uncertainty about relationship with donor-conceived child’. LIMITATIONS, REASONS FOR CAUTION: Findings may not be representative of all sperm donors as only one online connection site and one HFEA registered sperm bank were used for recruitment. …”
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    A comparison of the characteristics, motivations, preferences and expectations of men donating sperm online or through a sperm bank
  17. 119857
    “…In 124 live born singletons from fresh embryo transfers and in 45 from transfers of cryopreserved embryos, birthweight was similar in both oxygen groups after correction for confounding factors. LIMITATIONS, REASONS FOR CAUTION: This is a retrospective study, and treatment allocation was not randomised. …”
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    Reduced oxygen concentration during human IVF culture improves embryo utilization and cumulative pregnancy rates per cycle
  18. 119858
    “…LARGE SCALE DATA: N/A LIMITATIONS, REASONS FOR CAUTION: Ex vivo culture may not replicate all aspects of fetal gonadal development and function in vivo. …”
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    Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes
  19. 119859
    “…National registries of ART and IUI are in place in 31 out of the 43 countries contributing to the survey, and a registry of donors exists in 18 of them. LIMITATIONS, REASONS FOR CAUTION: The responses were provided by well-informed and committed individuals and submitted to double checking. …”
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    Survey on ART and IUI: legislation, regulation, funding and registries in European countries: The European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE)
  20. 119860
    “…The 5th percentile for SpO(2) was in reasonable agreement with the WHO definition of hypoxaemia in all regions except for Peru (the highest altitude site). …”
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    Effects of high altitude on respiratory rate and oxygen saturation reference values in healthy infants and children younger than 2 years in four countries: a cross-sectional study
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