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119901por de Nie, I, Mulder, C L, Meißner, A, Schut, Y, Holleman, E M, van der Sluis, W B, Hannema, S E, den Heijer, M, Huirne, J, van Pelt, A M M, van Mello, N M“…Cessation of hormonal treatment prior to gGAS did not affect the presence of germ cells or their maturation stage, nor was there an effect of the duration of hormonal treatment prior to gGAS. LIMITATIONS, REASONS FOR CAUTION: Since data on serum hormone levels on the day of gGAS were not available, we were unable to verify if the transgender women who were asked to temporarily stop hormonal treatment 4 weeks prior to surgery actually did so, and if people with full spermatogenesis were compliant to treatment. …”
Publicado 2021
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119902por Zondervan, Krina T, Missmer, Stacey, Abrao, Mauricio S, Einarsson, Jon I, Horne, Andrew W, Johnson, Neil P, Lee, Ted T M, Petrozza, John, Tomassetti, Carla, Vermeulen, Nathalie, Grimbizis, Grigoris, De Wilde, Rudy Leon“…The vast majority of respondents replied positively to the question on whether they would use a simple surgical descriptive system available for endometriosis, if available. LIMITATIONS, REASONS FOR CAUTION: While the total number of respondents was acceptable, some regions/professions were not sufficiently represented to draw conclusions. …”
Publicado 2022
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119903“…The four themes were: (i) heterogeneity in information provision during treatment planning; (ii) the need for improved HCP-patient collaboration; (iii) the need to temper optimism about treatment success; and (iv) apprehension, benefits and preferences regarding multi-cycle planning. LIMITATIONS, REASONS FOR CAUTION: Most patients were women from private fertility clinics with no previous treatment experience recruited from social media websites, mainly associated with patient support groups. …”
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119904por Hall, Courtney D., Herdman, Susan J., Whitney, Susan L., Anson, Eric R., Carender, Wendy J., Hoppes, Carrie W., Cass, Stephen P., Christy, Jennifer B., Cohen, Helen S., Fife, Terry D., Furman, Joseph M., Shepard, Neil T., Clendaniel, Richard A., Dishman, J. Donald, Goebel, Joel A., Meldrum, Dara, Ryan, Cynthia, Wallace, Richard L., Woodward, Nakia J.“…Based on moderate evidence, clinicians may use achievement of primary goals, resolution of symptoms, normalized balance and vestibular function, or plateau in progress as reasons for stopping therapy. Based on moderate to strong evidence, clinicians may evaluate factors, including time from onset of symptoms, comorbidities, cognitive function, and use of medication that could modify rehabilitation outcomes. …”
Publicado 2022
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119905por Dreyer Holt, Marianne, Warzecha, Agnieszka Katarzyna, Bülow, Nathalie Søderhamn, Skouby, Sven Olaf, Englund, Anne Lis Mikkelsen, Birch Petersen, Kathrine, Macklon, Nicholas Stephen“…Testosterone levels were significantly higher in the letrozole group (P = 0.005) and showed a non-significant trend that negatively correlated with UPF in the placebo group (P-value = 0.071, R = –0.48). LIMITATIONS, REASONS FOR CAUTION: Limitations of the study included the limited sample size and the lack of a power calculation specifically determined for this endpoint. …”
Publicado 2022
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119906por Ruohonen, Suvi T, Gaytan, Francisco, Usseglio Gaudi, Andrea, Velasco, Inmaculada, Kukoricza, Krisztina, Perdices-Lopez, Cecilia, Franssen, Delphine, Guler, Ipek, Mehmood, Arfa, Elo, Laura L, Ohlsson, Claes, Poutanen, Matti, Tena-Sempere, Manuel“…LARGE SCALE DATA: N/A. LIMITATIONS, REASONS FOR CAUTION: Conditional ablation of Gpr54 in oocytes unambiguously caused premature ovulatory failure in mice; yet, the ultimate molecular mechanisms for such state of POI can be only inferred on the basis of RNAseq data and need further elucidation, since some of the molecular changes observed in OoGpr54(−/−) ovaries were secondary to the anovulatory state. …”
Publicado 2022
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119907por Pietersma, C S, Mulders, A G M G J, Sabanovic, A, Willemsen, S P, Jansen, M S, Steegers, E A P, Steegers-Theunissen, R P M, Rousian, M“…Furthermore, using the unadjusted model, 40–60% of the association between smoking and fetal ultrasound parameters and 6.3% of the association between smoking and birth weight can be explained by a delayed embryonic morphology. LIMITATIONS, REASONS FOR CAUTION: The study population was recruited from a tertiary referral center. …”
Publicado 2022
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119908por Rimmer, Michael P, Howie, Ruth A, Anderson, Richard A, Barratt, Christopher L R, Barnhart, Kurt T, Beebeejaun, Yusuf, Bertolla, Ricardo Pimenta, Bhattacharya, Siladitya, Björndahl, Lars, Bortoletto, Pietro, Brannigan, Robert E, Cantineau, Astrid E P, Caroppo, Ettore, Collura, Barbara L, Coward, Kevin, Eisenberg, Michael L, De Geyter, Christian, Goulis, Dimitrios G, Henkel, Ralf R, Ho, Vu N A, Hussein, Alayman F, Huyser, Carin, Kadijk, Jozef H, Kamath, Mohan S, Khashaba, Shadi, Kobori, Yoshitomo, Kopeika, Julia, Kucuk, Tansu, Luján, Saturnino, Matsaseng, Thabo Christopher, Mathur, Raj S, McEleny, Kevin, Mitchell, Rod T, Mol, Ben W, Murage, Alfred M, Ng, Ernest H Y, Pacey, Allan, Perheentupa, Antti H, Du Plessis, Stefan, Rives, Nathalie, Sarris, Ippokratis, Schlegel, Peter N, Shabbir, Majid, Śmiechowski, Maciej, Subramanian, Venkatesh, Sunkara, Sesh K, Tarlarzis, Basil C, Tüttelmann, Frank, Vail, Andy, van Wely, Madelon, Vazquez-Levin, Mónica H, Vuong, Lan N, Wang, Alex Y, Wang, Rui, Zini, Armand, Farquhar, Cindy M, Niederberger, Craig, Duffy, James M N“…Evidence from randomized trials can be difficult to interpret and of limited ability to inform clinical practice for numerous reasons. These may include complex issues, such as variation in outcome measures and outcome reporting bias, as well as failure to consider the perspectives of men and their partners with lived experience of fertility problems. …”
Publicado 2022
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119909por Onogi, Sachie, Ezoe, Kenji, Kawasaki, Nami, Hayashi, Hiroko, Kuroda, Tomoko, Takeshima, Kazumi, Tanoue, Kaou, Nishii, Shogo, Kato, Keiichi“…The incidence of each congenital anomaly was similar among the groups. LIMITATIONS, REASONS FOR CAUTION: The study data were collected through self-reported parental questionnaires on maternal and neonatal outcomes. …”
Publicado 2022
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119910por Zaat, T R, de Bruin, J P, Goddijn, M, Visser, J, Kaaijk, E M, Lambalk, C B, Groenewoud, E R, van Wely, M, Mol, F“…Concerning the PRES, we found that women felt more empowered during home-based monitoring (P = 0.001) and classified the home-based monitoring as more discreet (P = 0.000) compared to the hospital-based monitoring. LIMITATIONS, REASONS FOR CAUTION: The results are applicable only to women undergoing NC-FET and not to women undergoing artificial cycle FET. …”
Publicado 2020
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119911por Andersen, Emil, Juhl, Christian R, Kjøller, Emma T, Lundgren, Julie R, Janus, Charlotte, Dehestani, Yasmin, Saupstad, Marte, Ingerslev, Lars R, Duun, Olivia M, Jensen, Simon B K, Holst, Jens J, Stallknecht, Bente M, Madsbad, Sten, Torekov, Signe S, Barrès, Romain“…Semen volume, sperm motility and motile sperm count did not change. LIMITATIONS, REASONS FOR CAUTION: The S-LITE trial was a randomized controlled trial of weight loss maintenance. …”
Publicado 2022
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119912por Moolhuijsen, Loes M E, Louwers, Yvonne V, McLuskey, Anke, Broer, Linda, Uitterlinden, Andre G, Verdiesen, Renée M G, Sisk, Ryan K, Dunaif, Andrea, Laven, Joop S E, Visser, Jenny A“…In silico analysis suggested a decreased binding affinity of the TFs steroidogenenic factor 1, estrogen-related receptor alpha and glucocorticoid receptor to the minor allele G variant, however in vitro analysis did not show a difference in promoter activity between the A and G allele. LIMITATIONS, REASONS FOR CAUTION: Functional analyses were performed in a mouse and a human granulosa cell line using an AMH promoter reporter construct. …”
Publicado 2022
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119913por Krog, Maria Christine, Hugerth, Luisa W, Fransson, Emma, Bashir, Zahra, Nyboe Andersen, Anders, Edfeldt, Gabriella, Engstrand, Lars, Schuppe-Koistinen, Ina, Nielsen, Henriette Svarre“…LARGE SCALE DATA: The microbiome samples analysed in this study were submitted to the European Nucleotide Archive under project number PRJEB37731, samples ERS4421369–ERS4422941. LIMITATIONS, REASONS FOR CAUTION: The cohort is homogenous which limits extrapolation of the effects of ethnicity and socio-economic status on the microbiome. …”
Publicado 2022
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119914“…It provides a theoretical basis for investors to reasonably respond to the Belt and Road investment in an emergency. …”
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119915“…SUBJECTS AND METHODS: The reasons for the above phenomena include the difficulty of crew certificate examination, insufficient time for relevant professional courses, weak cultural foundation of students, lack of learning perseverance, etc. …”
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119916por Wijs, L A, Doherty, D A, Keelan, J A, Panicker, V, Burton, P, Yovich, J L, Hart, R J“…Thyroid function did not differ between ET and FET, and no correlation between pE2 and fT4 was reported. LIMITATIONS, REASONS FOR CAUTION: The observational nature of the study limits the ability to prove causation. …”
Publicado 2022
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119917por Wu, YunDuo, Shen, Wenli, Wang, Qizheng, Cui, Changqiang, Zha, Li, Lu, Yan Jiao, Liu, Rui, Lin, Xiaofei, Zhu, Hongli“…CONCLUSION: Troponin level and pediatric SOFA score can be adopted as effective indicators to assess the severity and prognosis of patients with sepsis and can guide the formulation of a reasonable treatment plan.…”
Publicado 2022
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119918por Ruane, Peter T, Garner, Terence, Parsons, Lydia, Babbington, Phoebe A, Wangsaputra, Ivan, Kimber, Susan J, Stevens, Adam, Westwood, Melissa, Brison, Daniel R, Aplin, John D“…LARGE SCALE DATA: No omics datasets were generated in this study, and those used from previously published studies are cited. LIMITATIONS, REASONS FOR CAUTION: In vitro and in silico models may not recapitulate the dynamic embryo-endometrial interactions that occur in vivo. …”
Publicado 2022
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119919por Melville, Andrew“…In this case, the combination of apremilast and sulfasalazine was reasonably successful, but further flares might warrant a change in therapy, taking account of the dactylitis history. …”
Publicado 2022
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119920“…Participants in the process evaluation reported MyJourney was needed and answered their needs for support (reflecting high demand and acceptability), the recommended period to engage with MyJourney was short, and their engagement was influenced by multiple factors, including personal (e.g. lack of time) and MyJourney related (e.g. reminders). LIMITATIONS, REASONS FOR CAUTION: Participants were mostly white, well-educated, employed, childless women. …”
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