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  1. 119901
    “…Cessation of hormonal treatment prior to gGAS did not affect the presence of germ cells or their maturation stage, nor was there an effect of the duration of hormonal treatment prior to gGAS. LIMITATIONS, REASONS FOR CAUTION: Since data on serum hormone levels on the day of gGAS were not available, we were unable to verify if the transgender women who were asked to temporarily stop hormonal treatment 4 weeks prior to surgery actually did so, and if people with full spermatogenesis were compliant to treatment. …”
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  2. 119902
    “…The vast majority of respondents replied positively to the question on whether they would use a simple surgical descriptive system available for endometriosis, if available. LIMITATIONS, REASONS FOR CAUTION: While the total number of respondents was acceptable, some regions/professions were not sufficiently represented to draw conclusions. …”
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  3. 119903
    por Harrison, C, Boivin, J, Gameiro, S
    Publicado 2022
    “…The four themes were: (i) heterogeneity in information provision during treatment planning; (ii) the need for improved HCP-patient collaboration; (iii) the need to temper optimism about treatment success; and (iv) apprehension, benefits and preferences regarding multi-cycle planning. LIMITATIONS, REASONS FOR CAUTION: Most patients were women from private fertility clinics with no previous treatment experience recruited from social media websites, mainly associated with patient support groups. …”
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  4. 119904
    “…Based on moderate evidence, clinicians may use achievement of primary goals, resolution of symptoms, normalized balance and vestibular function, or plateau in progress as reasons for stopping therapy. Based on moderate to strong evidence, clinicians may evaluate factors, including time from onset of symptoms, comorbidities, cognitive function, and use of medication that could modify rehabilitation outcomes. …”
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  5. 119905
    “…Testosterone levels were significantly higher in the letrozole group (P = 0.005) and showed a non-significant trend that negatively correlated with UPF in the placebo group (P-value = 0.071, R = –0.48). LIMITATIONS, REASONS FOR CAUTION: Limitations of the study included the limited sample size and the lack of a power calculation specifically determined for this endpoint. …”
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  6. 119906
    “…LARGE SCALE DATA: N/A.  LIMITATIONS, REASONS FOR CAUTION: Conditional ablation of Gpr54 in oocytes unambiguously caused premature ovulatory failure in mice; yet, the ultimate molecular mechanisms for such state of POI can be only inferred on the basis of RNAseq data and need further elucidation, since some of the molecular changes observed in OoGpr54(−/−) ovaries were secondary to the anovulatory state. …”
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  7. 119907
    “…Furthermore, using the unadjusted model, 40–60% of the association between smoking and fetal ultrasound parameters and 6.3% of the association between smoking and birth weight can be explained by a delayed embryonic morphology. LIMITATIONS, REASONS FOR CAUTION: The study population was recruited from a tertiary referral center. …”
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  8. 119908
    por Rimmer, Michael P, Howie, Ruth A, Anderson, Richard A, Barratt, Christopher L R, Barnhart, Kurt T, Beebeejaun, Yusuf, Bertolla, Ricardo Pimenta, Bhattacharya, Siladitya, Björndahl, Lars, Bortoletto, Pietro, Brannigan, Robert E, Cantineau, Astrid E P, Caroppo, Ettore, Collura, Barbara L, Coward, Kevin, Eisenberg, Michael L, De Geyter, Christian, Goulis, Dimitrios G, Henkel, Ralf R, Ho, Vu N A, Hussein, Alayman F, Huyser, Carin, Kadijk, Jozef H, Kamath, Mohan S, Khashaba, Shadi, Kobori, Yoshitomo, Kopeika, Julia, Kucuk, Tansu, Luján, Saturnino, Matsaseng, Thabo Christopher, Mathur, Raj S, McEleny, Kevin, Mitchell, Rod T, Mol, Ben W, Murage, Alfred M, Ng, Ernest H Y, Pacey, Allan, Perheentupa, Antti H, Du Plessis, Stefan, Rives, Nathalie, Sarris, Ippokratis, Schlegel, Peter N, Shabbir, Majid, Śmiechowski, Maciej, Subramanian, Venkatesh, Sunkara, Sesh K, Tarlarzis, Basil C, Tüttelmann, Frank, Vail, Andy, van Wely, Madelon, Vazquez-Levin, Mónica H, Vuong, Lan N, Wang, Alex Y, Wang, Rui, Zini, Armand, Farquhar, Cindy M, Niederberger, Craig, Duffy, James M N
    Publicado 2022
    “…Evidence from randomized trials can be difficult to interpret and of limited ability to inform clinical practice for numerous reasons. These may include complex issues, such as variation in outcome measures and outcome reporting bias, as well as failure to consider the perspectives of men and their partners with lived experience of fertility problems. …”
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  9. 119909
    “…The incidence of each congenital anomaly was similar among the groups. LIMITATIONS, REASONS FOR CAUTION: The study data were collected through self-reported parental questionnaires on maternal and neonatal outcomes. …”
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  10. 119910
    “…Concerning the PRES, we found that women felt more empowered during home-based monitoring (P = 0.001) and classified the home-based monitoring as more discreet (P = 0.000) compared to the hospital-based monitoring. LIMITATIONS, REASONS FOR CAUTION: The results are applicable only to women undergoing NC-FET and not to women undergoing artificial cycle FET. …”
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  11. 119911
  12. 119912
    “…In silico analysis suggested a decreased binding affinity of the TFs steroidogenenic factor 1, estrogen-related receptor alpha and glucocorticoid receptor to the minor allele G variant, however in vitro analysis did not show a difference in promoter activity between the A and G allele. LIMITATIONS, REASONS FOR CAUTION: Functional analyses were performed in a mouse and a human granulosa cell line using an AMH promoter reporter construct. …”
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  13. 119913
    “…LARGE SCALE DATA: The microbiome samples analysed in this study were submitted to the European Nucleotide Archive under project number PRJEB37731, samples ERS4421369–ERS4422941. LIMITATIONS, REASONS FOR CAUTION: The cohort is homogenous which limits extrapolation of the effects of ethnicity and socio-economic status on the microbiome. …”
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  14. 119914
    “…It provides a theoretical basis for investors to reasonably respond to the Belt and Road investment in an emergency. …”
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  15. 119915
    “…SUBJECTS AND METHODS: The reasons for the above phenomena include the difficulty of crew certificate examination, insufficient time for relevant professional courses, weak cultural foundation of students, lack of learning perseverance, etc. …”
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  16. 119916
    “…Thyroid function did not differ between ET and FET, and no correlation between pE2 and fT4 was reported. LIMITATIONS, REASONS FOR CAUTION: The observational nature of the study limits the ability to prove causation. …”
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  17. 119917
    “…CONCLUSION: Troponin level and pediatric SOFA score can be adopted as effective indicators to assess the severity and prognosis of patients with sepsis and can guide the formulation of a reasonable treatment plan.…”
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  18. 119918
    “…LARGE SCALE DATA: No omics datasets were generated in this study, and those used from previously published studies are cited. LIMITATIONS, REASONS FOR CAUTION: In vitro and in silico models may not recapitulate the dynamic embryo-endometrial interactions that occur in vivo. …”
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  19. 119919
    por Melville, Andrew
    Publicado 2022
    “…In this case, the combination of apremilast and sulfasalazine was reasonably successful, but further flares might warrant a change in therapy, taking account of the dactylitis history. …”
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  20. 119920
    “…Participants in the process evaluation reported MyJourney was needed and answered their needs for support (reflecting high demand and acceptability), the recommended period to engage with MyJourney was short, and their engagement was influenced by multiple factors, including personal (e.g. lack of time) and MyJourney related (e.g. reminders). LIMITATIONS, REASONS FOR CAUTION: Participants were mostly white, well-educated, employed, childless women. …”
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