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292681“…The concentration of LPO products can influence the state of insulin receptors, repressing their hormone connection activity, which is expressed as a reduction of the glucose consumption by cells. …”
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292682por Rokonay, Réka, Veres-Székely, Apor, Szebeni, Beáta, Pap, Domonkos, Lippai, Rita, Béres, Nóra J., Veres, Gábor, Szabó, Attila J., Vannay, Ádám“…Effect of recombinant IL-1β, TNF-α, TGF-β and IL-17 treatment on the expression of IL19, IL20, IL24 and their receptors was investigated by real-time RT-PCR in small intestinal epithelial cells (FHs74Int), in primary duodenal myofibroblasts (pdMFs) and in peripheral blood mononuclear cells (PBMCs). …”
Publicado 2020
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292683por Rao Muvva, Jagadeeswara, Parasa, Venkata Ramanarao, Lerm, Maria, Svensson, Mattias, Brighenti, Susanna“…We used an in vitro macrophage Mtb infection model to assess both phenotype and functional markers i.e., inhibitory and scavenger receptors, costimulatory molecules, cytokines, chemokines, and effector molecules using flow cytometry and quantitative mRNA analysis. …”
Publicado 2020
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292684por Romano, Andrea, Xanthoulea, Sofia, Giacomini, Elisa, Delvoux, Bert, Alleva, Eugenia, Vigano, Paola“…Cell lines Z11 and Z12, the most diffused endometriosis cell lines, were characterised with respect to the expression of Pax2, steroid hormone receptors and STR profile. MAIN RESULTS AND THE ROLE OF CHANCE: From the literature review work, we underscored the lack of sufficient cell purity and phenotypic characterisation of primary cell cultures, which present high risk of contaminations from surrounding non-endometriotic tissues. …”
Publicado 2020
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292685“…BACKGROUND: Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. …”
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292686“…Briefly, exposure of the nasal mucosa to allergen in a sensitized individual leads to the release and further production of inflammatory mediators and the release of cytokines.(5) These released cytokines activate endothelial cells, thereby inducing expression of adhesion receptors on the cell surface and initiating a cascade of events that facilitates transendothelial migration of inflammatory cells. …”
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292687“…The discovery of neuro-mediators and cytokines and their receptors shared by the central nervous system and the immune system has prompted research work using reliable methodologies to study the relationship between a ‘hard’ scientific field, such as immunology, and a ‘soft’ one, such as the behavioral sciences. …”
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292688“…This could reflect enhanced antidiuretic response to low circulating ADH levels, possibly due to lower rate of solute extraction in dehydration, upregulation of ADH receptors due to chronic hormone deficiency, and to a fall in glomerular filtration rate. …”
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292689por Dichtel, Laura E, Nyer, Maren, Dording, Christina, Fisher, Lauren B, Cusin, Christin, Shapero, Benjamin G, Pedrelli, Paola, Kimball, Allison, Rao, Elizabeth M, Mischoulon, David, Fava, Maurizio, Miller, Karen Klahr“…The neuroactive steroid metabolite of progesterone, allopregnanolone, is a positive allosteric modulator of GABA(A) receptors and a putative treatment for mood disorders. …”
Publicado 2020
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292690“…Discussion: MA, by virtue of affinity for glucocorticoid receptors, has the potential to cause hyperglycemia and Cushing’s syndrome. …”
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292691por Yamamoto, Koichiro, Hanayama, Yoshihisa, Hasegawa, Kou, Yasuda, Miho, Tokumasu, Kazuki, Hagiya, Hideharu, Ogawa, Hiroko, Obika, Mikako, Otsuka, Fumio“…Other causes of hyperprolactinemia include hypothyroidism, chronic kidney disease and pregnancy. Also, PRL receptors have been considered as therapeutic targets for some cancers and autoimmune diseases. …”
Publicado 2020
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292692por Wangnoo, Subhash Kumar, Siddiqui, Mohammad Asim, Pamnani, Harsha, Usman, Khwaja Mohammed“…Tyrosine kinase inhibitors (TKI) belong to a new class of molecular multi-targeted anticancer therapy which targets different growth factor receptors and hence attenuates cancer cell survival and growth. …”
Publicado 2020
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292693por Seejore, Khyatisha, Giannoudi, Marilena, Osborn, Djoah, Lynch, Julie Marie, Dunwoodie, Elaine, Hook, Jane, Marples, Maria, Murray, Robert Douglas“…Introduction Immune checkpoint inhibitors (ICIs) are immunomodulatory molecules that downregulate T-cell inhibiting-receptors or ligands to promote an enhanced anti-tumour response. …”
Publicado 2020
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292694“…The skin has been shown to express PTHrP and PTHrP receptors (10). PTHrP has also been detected in 100% of cutaneous SCCs even in the absence of hypercalcemia. (6,7). …”
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292695por Chaves, Carolina Marques, Bruinstroop, Eveline, Refetoff, Samuel, Yen, Paul Michael, Anselmo, Joao“…Hepatic regulation of lipid metabolism is dependent on thyroid hormone receptors (TRs) with TRβ as the predominantly expressed TR isoform in the liver. …”
Publicado 2020
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292696por Murthy, Deepa Badrinath, Alvarez, Ana Gutierrez, Vargas, Wendy S, Litao, Melissa Kaori Silva, Shah, Bina Cherryl“…It may occur via apoptotic cytokines, ligands and receptors, including T regulatory cells, tumor necrosis factors etc. …”
Publicado 2020
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292697por Miles, Tiffany K, Allensworth, Melody Lyn, Moreira, Ana Rita Silva, Odle, Angela Katherine, Haney, Anessa, Lagasse, Alexandra, MacNicol, Angus M, Childs, Gwen V“…We showed that loss of somatotrope leptin receptors in mice reduces growth hormone (GH) secretion and promotes metabolic dysfunction in adults. …”
Publicado 2020
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292698por Schiffer, Hans, Atienza, Josephine, Reichard, Holly, Mulligan, Victoria, Cilia, Jackie, Monenschein, Holger, Collia, Deanna, Ray, Jim, Kilpatrick, Gavin, Brice, Nicola, Carlton, Mark, Hitchcock, Steve, Corbett, Ged, Hodgson, Robert“…Building on data previously reported at SIRS2018, we further explored modulation of GPR139 receptors and habenula circuitry in vivo as a novel mechanism to treat negative symptoms in SCZ. …”
Publicado 2020
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292699“…Stem cell maintenance, neuronal migration and cell survival are regulated by signaling of the CXC motif chemokine 12 (CXCL12) through CXC motif chemokine receptors 4 (CXCR4) and 7 (CXCR7), which are increasingly implicated in the pathophysiology of psychiatric disorders. …”
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292700por Jang, Jun Ho, Kim, Youjin, Park, Silvia, Kim, Kihyun, Kim, Seok Jin, Kim, Won Seog, Jung, Chul Won, Lee, Jeeyun, Lee, Se-Hoon“…Secondary end points included changes in transferrin saturation and levels of soluble transferrin receptors, hepcidin, erythropoietin, interleukin-6, and C-reactive protein (CRP) at each visit. …”
Publicado 2020
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