“…Small molecules were once considered the missing link in the “central dogma”; however, recently they have acquired a central role, and their general perception as downstream products has become reductionist. Metabolomics is a large-scale analysis of metabolites, and this emerging field has been shown to be the closest omics associated with the phenotype and concomitantly, the basis for all omics. …”
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“…At this juncture, when neuroscience is gradually abandoning the reductionist approach in favor of the direct investigation of complex neuronal systems, minimally invasive methods for brain tissue stimulation are becoming the basic element in the toolbox of those involved in the field. …”
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“…Both examples of phase separation have enabled reductionist biochemical assays allowing discovery of an N-terminal region of 57 residues that assembles into a labile, cross-β structure. …”
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“…In addition to in vivo and mathematical models, in vitro axonal injury models provide a simple, robust, and reductionist platform to partially understand nerve injury pathogenesis and regeneration. …”
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“…At this juncture, when neuroscience is gradually abandoning the reductionist approach in favor of the direct investigation of complex neuronal systems, minimally invasive methods for brain tissue stimulation are becoming the basic element in the toolbox of those involved in the field. …”
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“…We employed systematic literature mining, reductionist approach to gene expression profile and empirical in vitro work to highlight the role of a Nudix hydrolase family member, NUDT16, in sepsis. …”
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“…Weakly-bound intermolecular clusters constitute reductionist physical models for non-covalent interactions. …”
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“…The discovery of the limitations of the reductionist paradigm in the mathematical treatment of certain physical phenomena originated the notion of complexity, both as a pattern and process. …”
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“…Second, anti-realists assume their opponents hold a fully reductionist metaphysics, in which fundamental physics describes the only ground truth, thereby placing it beyond direct human sensory observation. …”
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“…Therefore, we established a reductionist liposomal membrane model system to imitate the plasma membrane of mouse T(reg) and T(conv) with regards to their ceramide content. …”
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“…Systems biology has been increasingly applied with multiple omics for a holistic comprehension of complex biological systems beyond the reductionist approach that focuses on individual molecules. …”
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“…This study employs the Buddhist tetralemmic dialectic (catuṣkoṭi), which goes beyond the limitations of dualistic and reductionist logic, to construct the Dialectical Mandala Model of Self-cultivation as the first of a two-step epistemological strategy. …”
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“…As simplified and completely defined microbiota, SynComs offer a promising reductionist approach to understanding the multispecies and multikingdom interactions in the microbe–host-immune axis. …”
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“…The contributing papers, which are methodologically pluralistic and provide rich conceptualisations of precarity, challenge reductionist individualist understandings of suffering and coping and extend social science theorizations on precarity. …”
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“…Faced with this complex process, health professionals need to seek the central relationships of the concepts of safety and palliative care to the end of life, in line with the wishes and expectations of the person and family members/caregivers, as well as with available resources and the capacity of services but, above all, reinforcing the importance of a non-reductionist care approach, which encompasses the various aspects inherent to humans. …”
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“…Results: Four key barriers were found. First, a reductionist approach prevails in the political narrative. …”
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“…Similar increases are also seen in reductionist mouse primary cell and human induced pluripotent stem cell (iPSC)-derived organoids perturbed by Y-27632, dependent on the presence of stromal cells. …”
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“…The conventional reductionist approach to cardiovascular research investigates individual candidate factors or linear signalling pathways but ignores more complex interactions in biological systems. …”
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“…Departments, universities and disciplines tend to form intellectual silos and adopt reductionist approaches. Forming a more integrated (or ‘constructionist'), problem-based science reflective of transdisciplinary research requires the adoption of novel practices to overcome these obstacles.…”
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“…In bipedal locomotion, the ‘compass gait’, a reductionist model of inverted pendulum walking, predicts the boundaries of speed and step length within which walking is feasible. …”
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