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281por Nilsson, Christina, Olafsdottir, Olof Asta, Lundgren, Ingela, Berg, Marie, Dellenborg, Lisen“…Results: The midwives’ care was provided in a field of tension in which they had to balance contrasting models of care, described in the themes: The birthing rooms and the office—Different rooms of care, Women giving birth or being delivered—Midwives’ expectations and relationships with women, Old and new caring roles of the midwife—Women giving birth in a “new age”, Being and doing—Different approaches to caring, and Holistic and reductionist care—Guided by contrasting models and guidelines. …”
Publicado 2019
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282por Boivin, Antoine“…It also supports a more critical view of engagement science, moving beyond reductionist views of engagement as a "black box technology" to a more subtle view of this broad category of complex interventions. …”
Publicado 2018
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283por Wiss, David A.“…The biopsychosocial model integrates concepts from several disciplines, emphasizing multicausality rather than a reductionist approach. Potential solutions at multiple levels are presented, considering individual as well as population health. …”
Publicado 2019
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284“…Since the method was successfully applied to these pilot data, a proof of principle in a reductionist human brain cell model was attempted, using the SH-SY5Y cell line. …”
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285por Chmielewski, Piotr Paweł“…Therefore, it is important to recognise the limitations of these reductionist and disease-oriented approaches. Only holistic and evidence-based strategies might be useful in slowing down ageing and preventing age-related diseases in the future.…”
Publicado 2019
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286por Cerf‐Bensussan, Nadine“…The complexity of the gut microbiota represents, however, a considerable challenge, and reductionist approaches are indispensable to define the contribution of individual bacteria to host responses and to dissect molecular mechanisms. …”
Publicado 2019
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287por Gatrell, Anthony C.“…As a vehicle for moving away from reductionist accounts, complexity theory potentially has much to say to those interested in research on health inequalities, spatial diffusion, emerging and resurgent infections, and risk. …”
Publicado 2005
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288“…Complementing the reductionist approach of molecular biology, based on the detailed study of a small number of genes, systemic approaches to human diseases consider that these are better reflected in large and intricate networks of relationships between genes. …”
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289“…We suggest this is, in part, because conventional policy analysis methods tend to be reductionist, considering causal mechanisms in relative isolation and conceptualizing them as linear chains of cause and effect. …”
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290por Abu-Shah, Enas, Trendel, Nicola, Kruger, Philipp, Nguyen, John, Pettmann, Johannes, Kutuzov, Mikhail, Dushek, Omer“…In this study, using systematic experiments in a reductionist system, in which primary human CD8(+) T cell blasts are stimulated by recombinant peptides presented on MHC Ag alone, we show that different inflammatory cytokines have comparable Ag dose thresholds across a 25,000-fold variation in affinity. …”
Publicado 2020
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291por O’Leary, Diane“…Some insist that holism is a nonreductionist approach that aligns with some form of dualism, while others insist it’s a reductionist view that sets out to eradicate dualism. …”
Publicado 2020
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292por Boileau, Etienne, Doroudgar, Shirin, Riechert, Eva, Jürgensen, Lonny, Ho, Thanh Cao, Katus, Hugo A., Völkers, Mirko, Dieterich, Christoph“…Our understanding of the transition from physiological to pathological cardiac hypertrophy remains elusive and largely based on reductionist hypotheses. Here, we profiled the translatomes of 15 mouse hearts to provide a molecular blueprint of altered gene networks in early cardiac remodeling. …”
Publicado 2020
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293“…We support an approach that integrates sound reductionist scientific principles with well-informed, thorough preclinical and translational clinical experiments.…”
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294por Capp, Jean-Pascal, DeGregori, James, Nedelcu, Aurora M, Dujon, Antoine M, Boutry, Justine, Pujol, Pascal, Alix-Panabières, Catherine, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Marusyk, Andriy, Gatenby, Robert, Thomas, Frédéric“…A growing body of studies reveals limitations of reductionist approaches to explaining biological and clinical observations. …”
Publicado 2021
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295“…Although apoptotic DNases are simultaneously induced following toxic/oxidative cell injury and/or failed DNA repair, the study of DNases in apoptosis has generally been reductionist in approach, focusing on individual DNases rather than their possible cooperativity. …”
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296“…History, then, may show us how we can move from our current reductionist thinking focused on particular selected model organisms toward generalizations about this crucial process that operates across complex living systems and move closer to repairing our own damaged bodies.…”
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297“…This approach leads to a non-reductionist biological and simultaneously phenomenological theory of conscious experience, giving new perspectives for a science of consciousness. …”
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298“…Starting from neo-Broserupian propositions, we can engage with the sociopolitical and environmental aspects of terrace emergence, maintenance and abandonment. Non-reductionist avenues include identifying and dating different phases of development within single terrace systems, identifying a full crop-range, and other activities not generally associated with terraces (e.g. metallurgy). …”
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299“…We discuss the limitations of the conventional reductionist approach of e.e. estimation from assessing the enantiodetermining steps only. …”
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300“…To overcome this, we suggest two integrated approaches: (i) a top-down approach focused on building predictive models through large sample sizes, deep metagenomic sequencing, and effective collaboration; and (ii) a bottom-up reductionist approach focused on testing hypotheses using model systems.…”
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