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Mostrando 21 - 40 Resultados de 702 Para Buscar '"reductionist"', tiempo de consulta: 0.13s Limitar resultados
  1. 21
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    A Bayesian analysis of the chromosome architecture of human disorders by integrating reductionist data
  2. 22
    “…Here, we utilized a reductionist model coupled with multi-omics approaches to study the role of host-microbe interactions in intestinal inflammation. …”
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    Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation
  3. 23
    “…We have thus developed potent HIV bnAbs that may be more tractable vaccine goals compared to existing bnAbs, and we have proposed a strategy to elicit them. This reductionist approach to vaccine design, guided by antibody and antigen structure, could be applied to design candidate vaccines for other HIV bnAbs or protective Abs against other pathogens.…”
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    Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
  4. 24
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    Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
  5. 25
    “…As for GZMB(+) Bregs, we found that BANK1 was decreased in other subtypes of Bregs, including IL10(+) and CD24(hi)CD38(hi) transitional regulatory B cells, along with BANK1 was down-regulated in activated/differentiated B cells, as in CD40-activated B cells, in leukemia and plasma cells. Following a reductionist approach, biological concepts were extracted from BANK1 literature and allowed us to infer association between BANK1 and immune signaling pathways, as STAT1, FcγRIIB, TNFAIP3, TRAF6, and TLR7. …”
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    Connection of BANK1, Tolerance, Regulatory B cells, and Apoptosis: Perspectives of a Reductionist Investigation
  6. 26
    “…The latter comprises a number of neuronal populations including the first order metabolic neurons, appetite-stimulating agouti-related peptide (AgRP) neurons and appetite-suppressing proopiomelanocortin (POMC) neurons. Using an in vivo reductionist approach and POMC(Cre)-dependent CRISPR-Cas9, we demonstrate that miR-15a-5p protects from obesity. …”
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    In Vivo Reductionist Approach Identifies miR-15a Protecting Mice From Obesity
  7. 27
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    Reductionist methodology and the ambiguity of the categories of race and ethnicity in biomedical research: an exploratory study of recent evidence
  8. 28
    Libro
    Consciousness : confessions of a romantic reductionist /
  9. 29
    por Saba, Luca, Tagliagambe, Silvano
    Publicado 2023
    “…This paper explores the underlying principles and key contributions of quantitative medicine, as well as the context for its rise, including the development of new technologies and the influence of reductionist philosophies. The challenges and criticisms of this approach, and the need to balance reductionist and holistic approaches in order to achieve a comprehensive understanding of human health will be discussed. …”
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    Quantitative medicine: Tracing the transition from holistic to reductionist approaches. A new “quantitative holism” is possible?
  10. 30
    “…CONCLUSION: Our results suggest a strong reductionist approach for Ebola research probably influenced by the lethality of the disease. …”
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    Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative
  11. 31
    por Fardet, Anthony, Rock, Edmond
    Publicado 2015
    “…First, the consequences of applying a reductionist versus a holistic approach to nutrition science will be discussed. …”
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    From a Reductionist to a Holistic Approach in Preventive Nutrition to Define New and More Ethical Paradigms
  12. 32
    por Günther, Michael, Mörl, Falk
    Publicado 2021
    “…Here, we use human intradiscal pressure data to verify the predictions of a reductionist spine model, which has in fact only one joint degree of freedom. …”
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    Giraffes and hominins: reductionist model predictions of compressive loads at the spine base for erect exponents of the animal kingdom
  13. 33
    “…This suggests that there is intrinsic asymmetry in the effect of cell-cell contact in decreasing differentiation. Thus, our reductionist approaches provide new insights into the effect of the niche on keratinocyte differentiation. …”
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    A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation
  14. 34
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    The scientific challenge of the 21(st )century: from a reductionist to a holistic approach via systems biology
  15. 35
    por Overgaard, Morten, Mogensen, Jesper
    Publicado 2014
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    Visual perception from the perspective of a representational, non-reductionistic, level-dependent account of perception and conscious awareness
  16. 36
    “…Here, we developed an in vitro model which incorporates both elements of a reductionist cellular model and disruption of the clock/environment relationship using temperature as an environmental cue, as occurs in vivo. …”
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    A reductionist, in vitro model of environmental circadian disruption demonstrates SCN-independent and tissue-specific dysregulation of inflammatory responses
  17. 37
    “…Sepsis is a complex heterogeneous condition, and the current lack of effective risk and outcome predictors hinders the improvement of its management. Using a reductionist approach leveraging publicly available transcriptomic data, we describe a knowledge gap for the role of ACVR1B (activin A receptor type 1B) in sepsis. …”
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    Abundance of ACVR1B transcript is elevated during septic conditions: Perspectives obtained from a hands-on reductionist investigation
  18. 38
    “…An apoA-I mimetic peptide ELK-2A2K2E was designed with a reductionist approach and has shown exceptional activity in supporting cholesterol efflux but modest anti-inflammatory and anti-oxidant properties in vitro. …”
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    An Apolipoprotein A-I Mimetic Peptide Designed with a Reductionist Approach Stimulates Reverse Cholesterol Transport and Reduces Atherosclerosis in Mice
  19. 39
    “…For that purpose, we used a reductionist approach to map the proteomic, miRNA, metabolomic, and lipidomic profiles of EVs derived from human primary tumor (SCC-9) cells and matched lymph node metastatic (LN1) cells. …”
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    A Reductionist Approach Using Primary and Metastatic Cell–Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis
  20. 40
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    The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'
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