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  1. 441
    “…Despite the advances in bottom-up nanoengineering and surface chemistry, reductionist functionalization approaches remain inadequate in replicating the complex interfaces present in nature and cannot avoid exposure of foreign materials. …”
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    Nanoparticle biointerfacing via platelet membrane cloaking
  2. 442
    por Ewen, Shaun C, Hollinsworth, David
    Publicado 2016
    “…Such efforts need to be critically examined and rigorously evaluated to avoid the reproduction of pathologizing stereotypes and reductionist explanations for persistent poor outcomes for Aboriginal people.…”
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    “Unwell while Aboriginal”: iatrogenesis in Australian medical education and clinical case management
  3. 443
    “…Conventional approaches to studying antiviral responses have primarily used reductionist systems to assess the function of a single or a limited subset of molecules. …”
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    Systems biology: A tool for charting the antiviral landscape
  4. 444
    “…What happens at kinetochores after Mps1-dependent Bub3-Bub1 recruitment remains mechanistically unclear, and it is not known whether kinetochore proteins other than KNL1 have significant roles to play in checkpoint signaling and MCC generation. Here, we take a reductionist approach, avoiding the complexities of kinetochores, and demonstrate that co-recruitment of KNL1(Spc7) and Mps1(Mph1) is sufficient to generate a robust checkpoint signal and prolonged mitotic arrest. …”
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    Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies
  5. 445
    “…In the present study, we tested the hypothesis that succinate supplementation can improve cellular energy state under metabolically stressed conditions in a robust, reductionist in vitro model of mitochondrial dysfunction in which primary mixed glial cultures (astrocytes, microglia and oligodendrocytes) were exposed to the mitochondrial complex I inhibitor rotenone. …”
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    Succinate supplementation improves metabolic performance of mixed glial cell cultures with mitochondrial dysfunction
  6. 446
    “…We exploited genetic variation between natural occurring accessions to determine the genetic basis of individual nucleus and chromocenter morphometric parameters (area, perimeter, density, roundness, and heterogeneity) that together determine chromatin compaction. Our novel reductionist genetic approach revealed quantitative trait loci (QTL) for all measured traits. …”
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    Genetic Dissection of Morphometric Traits Reveals That Phytochrome B Affects Nucleus Size and Heterochromatin Organization in Arabidopsis thaliana
  7. 447
    por Sarkar, Fazlul H.
    Publicado 2016
    “…The lack of understanding of the resistance networks associated with this subpopulation of cells as well as reductionist, single protein-/pathway-targeted approaches have made ‘effective drug design’ a difficult task. …”
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    Novel Holistic Approaches for Overcoming Therapy Resistance in Pancreatic and Colon Cancers
  8. 448
    “…Results obtained from this robust reductionist system can complement more time consuming and complex studies of such pathways in primary T cells.…”
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    A cellular platform for the evaluation of immune checkpoint molecules
  9. 449
    “…BACKGROUND AND OBJECTIVE: The reductionist approach of neuronal cell culture has been useful for analyses of synaptic signaling. …”
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    Robot-Embodied Neuronal Networks as an Interactive Model of Learning
  10. 450
    “…RESULTS: The study revealed four emerging themes: (1) Lack of doctor–patient rapport. (2) Utilization of a paternalistic approach during treatment. (3) Utilization of a reductionist biomedical approach during treatment. (4) Patients’ concern with their improvement in health and doctor's demeanor. …”
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    Assessing the extent of utilization of biopsychosocial model in doctor–patient interaction in public sector hospitals of a developing country
  11. 451
    “…We challenge this reductionist assumption by employing a principled, well-defined measure of intrinsic cause-effect power–integrated information (Φ), and showing that, according to this measure, it is possible for a macro level to “beat” the micro level. …”
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    Black-boxing and cause-effect power
  12. 452
    “…However, contemporary research practices tend to take the reductionist aggregate approach: they do not segment AD patients before embarking on biomarker discovery. …”
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    The Importance of Sex Stratification in Autoimmune Disease Biomarker Research: A Systematic Review
  13. 453
    “…To test this in a direct reductionist approach, we transferred the Brassicaceae‐specific PRR ELONGATION FACTOR‐THERMO UNSTABLE RECEPTOR (EFR), conferring recognition of the bacterial EF‐Tu protein, from Arabidopsis thaliana to the legume Medicago truncatula. …”
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    Expression of the Arabidopsis thaliana immune receptor EFR in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen‐fixing rhizobial symbiosis
  14. 454
    por Kyriazis, Marios
    Publicado 2018
    “…Second, I propose that a ‘systems-thinking’ method needs to be more exten-sively employed, instead of relying exclusively on the current reductionist one. Third, it is submitted that we must learn from the history of life-extension research, and not blindly follow contemporary paradigms, which may lead us into yet more ‘dead ends’ with regards to therapies. …”
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    Four Principles Regarding an Effective Treatment of Aging
  15. 455
    “…In this study, we take a reductionist approach by specifically focusing on one trait: regrowth (the plant’s ability to restart a new life cycle after senescence on the same body). …”
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    The Genetics and Genome-Wide Screening of Regrowth Loci, a Key Component of Perennialism in Zea diploperennis
  16. 456
    “…Artificial surfaces are routinely used instead of leaves to enable a reductionist approach in phyllosphere microbiology, the study of microorganisms residing on plant leaf surfaces. …”
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    Comparison of replica leaf surface materials for phyllosphere microbiology
  17. 457
    por Rai, Pribat, Khawas, Vimal
    Publicado 2019
    “…Technocratic science must recognise the need for a relational or holistic approach rather than believing in reductionist approaches alone whilst dealing with natural calamities. …”
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    Traditional knowledge system in disaster risk reduction: Exploration, acknowledgement and proposition
  18. 458
    “…Current in vitro screening methods allow high-throughput but are biologically reductionist. The use of mammal models, which allow a better translatability for predicting clinical outputs, is low-throughput, highly expensive, and ethically controversial. …”
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    Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans
  19. 459
    “…A myriad of complementary, and increasingly sophisticated, experimental approaches can now be used across the research pipeline, from simple reductionist models devised to delineate molecular and cellular mechanisms, to complex animal models required for preclinical testing of new therapeutic approaches. …”
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    Experimental models and tools to tackle glioblastoma
  20. 460
    “…These surfaces enable a reductionist approach to be undertaken, to enable individual environmental factors influencing microorganisms to be studied. …”
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    Replicating Arabidopsis Model Leaf Surfaces for Phyllosphere Microbiology
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