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Mostrando 581 - 600 Resultados de 702 Para Buscar '"reductionist"', tiempo de consulta: 0.67s Limitar resultados
  1. 581
    “…We propose the current model as a tractable reductionist system to complement more complex models for further understanding how inflammation resolution in the brain is regulated and as a platform for in vivo testing/screening of candidate resolution-modifying interventions. …”
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    Myeloid Cell and Transcriptome Signatures Associated With Inflammation Resolution in a Model of Self-Limiting Acute Brain Inflammation
  2. 582
    “…Importantly, the multitude of the associated variants and their prevalence in the healthy population limit the potential of a reductionist functional genetics approach as a stand-alone solution to discover the disease pathology. …”
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    Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders
  3. 583
    por Guo, Li, Ji, Mengjie, Ye, Kai
    Publicado 2020
    “…Reconstructing F. graminearum dynamic TRNs, an NP (non-deterministic polynomial) -hard problem, remains unsolved using commonly adopted reductionist or co-expression based approaches. Multi-omic data such as fungal genomic, transcriptomic data and phenomic data are vital to but so far have been largely isolated and untapped for unraveling phenotype-specific TRNs. …”
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    Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin and sexual reproduction in Fusarium graminearum
  4. 584
    “…Metabolomics shows great potential to complement classical reductionist approaches to cost-effectively accelerate the rate of progress in expanding our global understanding of metabolic network structure and physiology. …”
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    Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a ridA Mutant of Salmonella enterica
  5. 585
    “…Its efficacy in HCM caused by mutations in thin filament proteins is not known. We show in reductionist and cellular models that mavacamten can rescue the effects of thin filament mutations on calcium sensitivity and calcium handling although it only partially rescues the contractile cellular phenotype and, in some cases, exacerbates the effect of the mutation.…”
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    Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca(2+) flux caused by thin filament hypertrophic cardiomyopathy mutations
  6. 586
    “…We take the view that the complexity of the immune system is an inevitable consequence of its evolution, and this complexity has frustrated reductionist efforts to develop host-directed therapies for infection. …”
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    Treatable traits and therapeutic targets: Goals for systems biology in infectious disease
  7. 587
    “…Upon adoptive transfer of human PBMC, this reductionist system allowed us to study human T cell recruitment from a circulating pool of T cells into non-inflamed human skin in vivo. …”
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    A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin
  8. 588
    “…The NSP1– C terminal structure in complex with ribosome using cryo-EM is available now, and the N-terminal region structure in isolation is also deciphered in literature. However, as a reductionist approach, the conformation of NSP1– C terminal region (NSP1-CTR; amino acids 131–180) has not been studied in isolation. …”
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    SARS-CoV-2 NSP1 C-terminal (residues 131–180) is an intrinsically disordered region in isolation
  9. 589
    “…The transition from figurative art to abstraction is “comparable” to the reductionist process that is used in the scientific field to explain complexity and phenomenology. …”
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    The Cage Case. Arts and Social Neuroscience
  10. 590
    “…Further, we have experimentally characterized the residue 91–112 by using reductionist approaches. CD spectroscopy suggests that the NSP6 (91–112) is disordered-like region in isolation, which gains helical conformation in different biological mimic environmental conditions. …”
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    Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91–112 & 231–290 regions
  11. 591
    “…Despite the complexity of ED operations, quality and safety improvement are often approached in a reactive, linear and reductionist manner. There is increasing interest in adopting Resilient Healthcare (RHC) techniques based on complex systems thinking as a method for quality improvement and research in EDs. …”
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    Resilient healthcare theory as a lens to research emergency department operations: a protocol for a scoping review
  12. 592
    por Rapti, Georgia
    Publicado 2022
    “…Nervous system cells, the building blocks of circuits, have been studied with ever-progressing resolution, yet neural circuits appear still resistant to schemes of reductionist classification. Due to their sheer numbers, complexity and diversity, their systematic study requires concrete classifications that can serve reduced dimensionality, reproducibility, and information integration. …”
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    Open Frontiers in Neural Cell Type Investigations; Lessons From Caenorhabditis elegans and Beyond, Toward a Multimodal Integration
  13. 593
    “…Histology and gene expression patterns of responders and non-responders were compared. RESULTS: A reductionist approach applying very tight criteria to identify caABMR and treatment response excluded the vast majority of clinical ABMR cases. …”
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    Histologic and Molecular Patterns in Responders and Non-responders With Chronic-Active Antibody-Mediated Rejection in Kidney Transplants
  14. 594
    “…A main challenge in persistence assessment is that existing frameworks rely on simplistic and reductionist evaluation schemes that may lead substances to be falsely assessed as persistent or the other way around—to be falsely assessed as nonpersistent. …”
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    Moving persistence assessments into the 21st century: A role for weight‐of‐evidence and overall persistence
  15. 595
    “…By integrating our interactome with expression data, we identified trends in the dynamics of immune interactions and constructed a reductionist mathematical model that predicts cellular connectivity from basic principles. …”
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    A physical wiring diagram for the human immune system
  16. 596
    “…The clusters with a higher, medium, lower scores can be classified as Twitter accounts of Holistic thinkers, Middle thinkers, and Reductionist thinkers, respectfully. In conclusion, systems thinking capabilities are traced through unique network patterns in relation to the follower network characteristics associated with systems thinking dimensions.…”
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    Integrated twitter analysis to distinguish systems thinkers at various levels: a case study of COVID-19
  17. 597
    por Loth, Eva
    Publicado 2023
    “…It is argued that the predominant reductionist approach, which seeks to parse complex issues into simpler, more tractable units, let us to neglect the interactions between brain and body, and divorce individuals from their social environment. …”
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    Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment
  18. 598
    “…As such, advanced co-cultures provide a pathologically relevant tractable system to study the role of the TME in breast cancer progression with a reductionist approach.…”
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    Advanced Cell Culture Models Illuminate the Interplay between Mammary Tumor Cells and Activated Fibroblasts
  19. 599
    “…Since Cav1.2 delivery to BIN1 occurs in reductionist non-myocyte cell lines, we find that other myocyte-specific structures are not essential and there is an intrinsic relationship between microtubule-based Cav1.2 delivery and its BIN1 scaffold. …”
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    BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules
  20. 600
    “…We take advantage of the glass-supported planar bi-layer system as a reductionist model to represent the surface of HIV-infected cells bearing the viral envelope gp120 and the cellular adhesion molecule ICAM-1. …”
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    Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
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