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Mostrando 601 - 620 Resultados de 702 Para Buscar '"reductionist"', tiempo de consulta: 0.20s Limitar resultados
  1. 601
    “…In addition, BreastMark can act as a powerful reductionist approach to these more complex gene signatures, eliminating superfluous genes, potentially reducing the cost and complexity of these multi-index assays. …”
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    BreastMark: An Integrated Approach to Mining Publicly Available Transcriptomic Datasets Relating to Breast Cancer Outcome
  2. 602
    “…CONCLUSIONS: Deliberations yielded qualitative, socially-negotiated evidence required to inform ethical, accountable policy decisions in the specific area of ART and health care more broadly. Notably, reductionist, deterministic characterizations of stakeholder ‘self-interest’ proved unfounded as each group sought to prioritise universal values (in particular, ‘equity’ and ‘responsibility’) over specific, within-group concerns. …”
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    Disinvestment policy and the public funding of assisted reproductive technologies: outcomes of deliberative engagements with three key stakeholder groups
  3. 603
    por Scannell, Jack W., Bosley, Jim
    Publicado 2016
    “…Perhaps there has also been too much enthusiasm for reductionist molecular models which have insufficient predictive validity. …”
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    When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis
  4. 604
    “…Neurological disorders exhibit a huge number of molecular alterations due to a complex interplay between genetic and environmental factors. Classical reductionist approaches are focused on a few elements, providing a narrow overview of the etiopathogenic complexity of multifactorial diseases. …”
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    Comparing Alzheimer’s and Parkinson’s diseases networks using graph communities structure
  5. 605
    “…We argue that current scientific understanding of the impact of street trees on human health and the urban environment has been limited by predominantly regional-scale reductionist approaches which consider vegetation generally and/or single out individual services or impacts without considering the wider synergistic impacts of street trees on urban ecosystems. …”
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    Health and climate related ecosystem services provided by street trees in the urban environment
  6. 606
    “…Due to the generic (and often reductionist) nature of such instruments, certain groups of respondents may experience challenges in describing their health state. …”
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    “When I saw walking I just kind of took it as wheeling”: interpretations of mobility-related items in generic, preference-based health state instruments in the context of spinal cord injury
  7. 607
    “…A trait-based characterization of the reference stock bacteria will permit future microbiota manipulation experiments to decipher overall microbiome functioning and elucidate the biological mechanisms and interactions driving the observed effects. The presented reductionist experimental approach offers countless opportunities for future systematic and functional examinations of the plant root microbiome. …”
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    Deciphering composition and function of the root microbiome of a legume plant
  8. 608
    “…This has advanced the science beyond that of reductionist scientific approaches by revealing novel interactions between and within the immune system and other biological systems (beyond transcriptional level), which are critical to developing “downstream” adaptive humoral and cellular responses to infectious pathogens and vaccines. …”
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    Personalized vaccinology: A review
  9. 609
    “…BACKGROUND: Ensuring patients benefit from the latest medical and technical advances remains a major challenge, with rational-linear and reductionist approaches to translating evidence into practice proving inefficient and ineffective. …”
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    Simple rules for evidence translation in complex systems: A qualitative study
  10. 610
    “…Rather than the serological and molecular-based methods, with their more “reductionist” view focusing on one or a few known agents, HTS-based approaches are able to give a “holistic snapshot” of the complex phytobiome of a sample of interest. …”
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    High-Throughput Sequencing and the Viromic Study of Grapevine Leaves: From the Detection of Grapevine-Infecting Viruses to the Description of a New Environmental Tymovirales Member
  11. 611
    “…Its popularity stems largely from its potential to address dilemmas inherent in the implementation of knowledge generated using more reductionist methods. However, despite increasing recognition, demands for co-produced research to illustrate its worth are becoming pressing while the means to do so remain challenging. …”
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    Embracing complexity and uncertainty to create impact: exploring the processes and transformative potential of co-produced research through development of a social impact model
  12. 612
    “…However, the narrative describing the involvement of local actors in the delivery of humanitarian aid in armed conflict settings remains reductionist and unreflective of the complex and circular course of the “localisation of aid”. …”
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    Localisation and cross-border assistance to deliver humanitarian health services in North-West Syria: a qualitative inquiry for The Lancet-AUB Commission on Syria
  13. 613
    “…Selecting the most appropriate animal model requires in-depth knowledge of specific species and breeds to ascertain the adequacy of the model and outcome measures that closely mirror the clinical situation. Traditional reductionist approaches in animal experiments, which often do not sufficiently reflect the studied disease, are still the norm and can result in a disconnect in outcomes observed between animal studies and clinical trials. …”
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    Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do
  14. 614
    “…On one hand, models grounded in reductionist perspectives tend to oversimplify the problems and thus fall short of capturing the true complexity that must be understood to make tangible progress. …”
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    Framing the Intractable: Comprehensive Success Factor Analysis for Grand Challenges
  15. 615
    “…RESULTS: Five major themes were identified from the focus groups. (1) Young people wanted a collaborative dialogue with GPs, which included being asked about suicidal behaviour/self-harm, informed of treatment processes and having autonomy in decision making; (2) young people were concerned with a loss of privacy when disclosing suicidal behaviour/self-harm; (3) young people viewed labels and assessments as problematic and reductionist—disliking the terms ‘risk’ and ‘risk assessment’, and assessment approaches that are binary and non-holistic; (4) young people highlighted the importance of GPs’ attitudes, with a genuine connection, attentiveness and a non-judgemental demeanour seen as paramount; and (5) young people wanted to be provided with practical support and resources, followed-up, and for GPs to be competent when working with suicidal behaviour/self-harm presentations. …”
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    Best practice when working with suicidal behaviour and self-harm in primary care: a qualitative exploration of young people’s perspectives
  16. 616
    “…Despite the current reductionist approach providing an optimal indication for diagnosis and treatment of patients with heart failure with reduced ejection fraction (HFrEF), there are no standard pharmacological therapies for heart failure with preserved ejection fraction (HFpEF). …”
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    Epigenetic Therapies for Heart Failure: Current Insights and Future Potential
  17. 617
    por Ball, Philip
    Publicado 2020
    “…The reductionist approach to science seeks to understand the behaviour of systems by studying their individual components. …”
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    More is different: how aggregation turns on the light
  18. 618
    “…Toward this end, we combined reductionist, transitional and ecological approaches, applied to the staple cereal crop sorghum to identify key root-associated microbes that robustly affect drought-stressed plant phenotypes. …”
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    Identification of beneficial and detrimental bacteria impacting sorghum responses to drought using multi-scale and multi-system microbiome comparisons
  19. 619
    “…We find that most exposure assessments in previous aging studies have used a reductionist approach, whereby the effect of only a single environmental factor or a specific class of environmental factors on the development of age-related diseases has been examined. …”
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    A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases
  20. 620
    por Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Giles, Corey, Huynh, Kevin, Nguyen, Anh, Wallace, Leanne, McLaren, Tiana, Yang, Yuanhao, Hernandez, Leanna M., Gandal, Michael J., Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Strike, Lachlan T., Cadby, Gemma, Moses, Eric K., de Zubicaray, Greig I., Thompson, Paul M., McMahon, Katie L., Wright, Margaret J., Visscher, Peter M., Dawson, Paul A., Dissanayake, Cheryl, Eapen, Valsamma, Heussler, Helen S., Whitehouse, Andrew J. O., Meikle, Peter J., Wray, Naomi R., Gratten, Jacob
    Publicado 2023
    “…Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. …”
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    Interactions between the lipidome and genetic and environmental factors in autism
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