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  1. 439041
    “…These findings provide, to our knowledge, the first evidence that brain glutamate levels are associated with emotional hyper-responsivity and volumetric changes in HS in brain regions thought to be critical in the pathophysiology of psychotic symptoms. …”
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    O6.2. NEUROBIOLOGY OF PSYCHOMETRIC SCHIZOTYPY: INSIGHTS FROM MULTIMODAL IMAGING RESEARCH
  2. 439042
    “…This data suggests that increases in pro-inflammatory cytokines extend to midbrain regions and may contribute to the neuropathology of the disorder by contributing to dopamine dysregulation. …”
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    40.1 INFLAMMATORY CYTOKINES ARE ELEVATED IN THE MIDBRAIN IN SCHIZOPHRENIA
  3. 439043
    “…In order to discover the possibly altered neuronal composition in schizophrenia numerous studies have been focussing mainly on different cortical regions such as the ventromedial prefrontal cortex and dorsolateral prefrontal cortex. …”
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    T196. CALRETININ INTERNEURON DENSITY IN THE CAUDATE NUCLEUS IS LOWER IN SCHIZOPHRENIA
  4. 439044
    por Perez, Stephanie, Lodge, Daniel
    Publicado 2018
    “…BACKGROUND: Aberrant regulation of dopamine system function is thought to contribute to psychosis in schizophrenia patients; however, the brain regions associated with this dysregulation have not been conclusively demonstrated. …”
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    O9.5. ABERRANT DOPAMINE SYSTEM FUNCTION REVERSED BY THE OREXIN RECEPTOR ANTAGONIST TCS1102 IN A RODENT MODEL OF SCHIZOPHRENIA
  5. 439045
    “…BACKGROUND: Accumulated evidence from non-human animal studies suggests that the prominent deficits in memory and executive function that characterise individuals with psychosis may, at least in part, be due to the effects of stress on the brain regions that support these functions. However, studies of patients with established psychosis have yielded inconsistent findings with regards to the relationship between stress and cognition, and research in high-risk populations is notably lacking. …”
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    O9.8. STRESS AND COGNITIVE FUNCTION AMONG INDIVIDUALS AT CLINICAL HIGH-RISK FOR PSYCHOSIS: FINDINGS FROM THE NAPLS COHORT
  6. 439046
    “…Here, we present surface expression, functional, and pharmacological analysis of 11 de novo missense mutations of the human hGluN2B subunit (P553L; V558I; W607C; N615I; V618G; S628F; E657G; G820E; G820A; M824R; L825V) located in the pre-M1, M1, M2, M3, and M4 membrane regions. These variants were identified in patients with intellectual disability, developmental delay, epileptic symptomatology, and autism spectrum disorder. …”
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    Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit
  7. 439047
    “…We further analyzed cis-mQTL for the three most significant SNPs and 5580 potential methylation loci within these target gene regions. Our results indicated that the SNPs rs1948 and rs7178270 in CHRNB4 and rs3743075 in CHRNA3 were significantly associated with the Fagerström Test for Nicotine Dependence (FTND) score (p = 6.6 × 10(−5); p = 2.0 × 10(−4), and p = 7.0 × 10(−4), respectively). …”
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    Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population
  8. 439048
    “…In addition, we observed a similar relationship between α-syn inclusion load and number of microglia expressing MHC-II in cortical regions, but not in the striatum. CONCLUSIONS: Our results demonstrate that increases in microglia displaying a reactive morphology and MHC-II expression occur in the substantia nigra in close association with peak numbers of pSyn inclusions, months prior to nigral dopamine neuron degeneration, and suggest that reactive microglia may contribute to vulnerability of SNc neurons to degeneration. …”
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    Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
  9. 439049
    “…We have investigated its effects in a heterogeneous frail cohort included in a regional CCM-based program. METHODS: a retrospective population-based cohort study was carried out involving a non-oncological cohort of adult subjects with chronic diseases included in the CCM-oriented program (Puglia Care). …”
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    The effects of the introduction of a chronic care model-based program on utilization of healthcare resources: the results of the Puglia care program
  10. 439050
    “…OBJECTIVE: The objective of this study was to demonstrate the successful extraction of clinical grade measures using a custom signal quality classification algorithm for the rejection of poor-quality regions and a robust QRS delineation algorithm from a nonstandard electrocardiogram (ECG) integrated into a toilet seat; a device plagued by many of the same challenges as wearable technologies and other Internet of Things–based medical devices. …”
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    Nontraditional Electrocardiogram and Algorithms for Inconspicuous In-Home Monitoring: Comparative Study
  11. 439051
    Publicado 2011
    “…The standardized uptake value (SUV) of tumor regions were calculated. Afer last PET/CT imaging, the rabbits were euthanized and the tumors were removed for histological and immunohistochemical examination. …”
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    CT导引下(32)P-磷酸铬-聚-L-乳酸粒子植入治疗兔VX2肺肿瘤的实验研究
  12. 439052
    Publicado 2011
    “…The confidence interval of the standardized rate ratio were adopted to evaluate the statistical significance of differences in different regions. RESULTS: 52, 833 villagers were surveyed and screened with X-ray. 604 of them were suspicious lung cancer with an initial chest radiograph, 541 underwent CT scan (362 were diagnosed by CT and 109 were diagnosed by histology). …”
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    滇东产(燃)煤区农民肺癌流行病学调查
  13. 439053
    “…This S3(15)-score was validated in 108 metastatic and non-metastatic ccRCC patients and ccRCC-derived metastases including in part several regions from one metastasis. Univariate and multivariate Cox regression stratified by T, N, M, and G were performed with cancer-specific and progression-free survival as primary endpoints. …”
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    Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma
  14. 439054
    “…Some virus lineages appeared to be unrelated to AIVs in wild bird populations in other regions, with maintenance of local AIVs in Georgia, whereas other lineages showed considerable genetic interrelationships with viruses circulating in other parts of Eurasia and Africa, despite relative undersampling in the area. …”
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    Avian Influenza Viruses in Wild Birds: Virus Evolution in a Multihost Ecosystem
  15. 439055
    “…A synteny analysis of regions surrounding zebrafish CAM paralogs was performed. …”
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    Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina
  16. 439056
    “…However, this may place undue financial burden on bite victims that have had a low-risk exposure and over-prescription may contribute to regional supply shortages. The results here indicate that in a low-resource country such as Haiti, a well-trained veterinary assessor can provide an accurate risk assessment of biting dogs based on a standard case investigation protocol. …”
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    Retrospective Cohort Study to Assess the Risk of Rabies in Biting Dogs, 2013–2015, Republic of Haiti
  17. 439057
    “…Deliverables included PACT-focused strategies to support integrated use of HIT in the ambulatory care setting that will also inform strategy development in other systems of care and support subsequent implementation efforts at regional and national levels. REGISTERED REPORT IDENTIFIER: RR1-10.2196/11262…”
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    Virtual Medical Modality Implementation Strategies for Patient-Aligned Care Teams to Promote Veteran-Centered Care: Protocol for a Mixed-Methods Study
  18. 439058
    “…These reveal the need for incorporation of integrated vector management strategies to complement DL installation especially in regions with high rainfall and mosquito density. Promising vector control tools such as DL should be evaluated on a long-term basis to reveal the possible effect of weather parameters on control performance and also allow for holistic recommendations. …”
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    Mind the weather: a report on inter-annual variations in entomological data within a rural community under insecticide-treated wall lining installation in Kwara State, Nigeria
  19. 439059
    “…CONCLUSIONS: Cytophilic IgG responses to the C-terminal and NANP repeat regions of CSP and anti-HBsAg antibodies induced by RTS,S/AS01E vaccination were associated with malaria protection. …”
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    Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children
  20. 439060
    “…Our study demonstrated that the depression of regional LS of RVFW is more pronounced in the basal and middle segments in CTEPH patients. …”
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    The value of speckle-tracking echocardiography in identifying right heart dysfunction in patients with chronic thromboembolic pulmonary hypertension
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