“…Ex vivo survival studies with relE2 and asrelE2 knockout strains showed that RelE2 contributes to Mtb survival in activated macrophages and low pH to nutrient limitation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, the product of ORF5 showed a fairly high identity (38–50%) and structural similarity (58–74%) to RelE of Streptococcus pneumoniae, Streptococcus equi, and Streptococcus downei. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we examined the relationship of (p)ppGpp with 15 common persister genes (dnaK, clpB, rpoS, pspF, tnaA, sucB, ssrA, smpB, recA, umuD, uvrA, hipA, mqsR, relE, dinJ) using Escherichia coli as a model. By comparing the persister levels of wild type with their single gene knockout and double knockout mutants with relA, we divided their interactions into five types, namely A “dependent” (dnaK, recA), B “positive reinforcement” (rpoS, pspF, ssrA, recA), C “antagonistic” (clpB, sucB, umuD, uvrA, hipA, mqsR, relE, dinJ), D “epistasis” (clpB, rpoS, tnaA, ssrA, smpB, hipA), and E “irrelevant” (dnaK, clpB, rpoS, tnaA, sucB, smpB, umuD, uvrA, hipA, mqsR, relE, dinJ). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Conversely, relF enhanced the toxicity of the relE toxin gene, while relB increased the toxicity of relK. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Structural studies of RelE and YoeB toxins bound to the ribosome provided significant insights but biochemical experiments with RelE were required to clearly demonstrate which residues are critical for acid-base catalysis of mRNA cleavage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The VcHigB2 is more closely related to Escherichia coli RelE both in terms of overall structure and the organization of its active site. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A broad phylogenetic distribution of RelE toxin genes was observed in gut associated bacterial species (Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria), but no RelE homologues were identified in gut associated archaeal species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among the TA modules, the ranking order was mqsR, lon, relE, tisAB, hipA, and dinJ. Intriguingly, rpoS deletion caused a defect in persistence to gentamicin but increased persistence to ampicillin and norfloxacin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In 2013 ICARUS concluded a very successful, long duration run with the T600 detector at the LNGS underground laboratory taking data both with the CNGS neutrino beam and with cosmic rays. Several rele- vant physics and technical results were achieved. …”
Enlace del recurso
Enlace del recurso

“…Deletion of the toxin, relE, did not result in plasmid instability but did increase the fitness of the mutant compared to the wild-type strain.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These impacts are associated with phenotypic changes in antibiotic sensitivity, biofilm formation, and cell motility and are regulated by stress response proteins, RelA and RelE, as well as the metabolic enzyme and virulence-associated protein, AdhE. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Kamsma, W. Q. Boon, T. ter Rele, C. Spitoni and R. van Roij, Phys. Rev. Lett., 2023, 130(26), 268401], the relative ease of fabrication of conical channels, and the wide range of achievable memory retention times by varying the channel lengths. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…INTRODUCTION In recent years, the need for a complete collection of information rele­ vant to diatomic moleeules has become evident. …”
Enlace del recurso
Enlace del recurso

“…However, the identification of rele-vant data elements and the creation of database jobs for extraction, transformation and loading (ETL) are challenging: With current methods such as data warehousing, it is not feasible to efficiently maintain and reuse semantically complex data extraction and trans-formation routines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The first gene in a TA operon codes for an antitoxin that combines with and neutralizes a regulatory ‘toxin’, encoded by the second gene. RelE and MazF toxins are regulators of translation that cleave mRNA and function, in interplay with tmRNA, in quality control of gene expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Comparison with other ribosome-dependent toxins RelE and YoeB reveals that each interacts with similar features of the 30S aminoacyl (A) site yet does so through presentation of diverse structural motifs.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrate that the relB/relE TA pair was active and resulted in RNA degradation when CB0101 was under oxidative stress caused by either zinc toxicity or high light intensities, but the growth inhibition was released when the stress was removed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RelB acted as a weak repressor, whereas RelE performed the role of a co-repressor. By DNA footprinting experiments, we show that the proteins bind to a region that encompasses two palindromic sequences that are located around the −10 sequences of the single promoter that directs the synthesis of the relBE mRNA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study aimed to investigate the hypothetical role of TA systems in persister cells formation of Brucella strains by evaluating toxins of type II TA systems (RelE, Fic, Brn T, cogT) expression. METHODS: Brucella strains treated with a lethal dose of gentamicin and ampicillin and to determine the number of surviving cells, bacterial colonies were counted at different time intervals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The proportion and intensity of the bi-modal response of mature biofilm cells was altered in mutants lacking the Type II toxins MazF and RelE, or in a strain lacking the (p)ppGpp synthase/hydrolase RelA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso