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98101por Barbosa, Joana, Faria, Juliana, Garcez, Fernanda, Leal, Sandra, Afonso, Luís Pedro, Nascimento, Ana Vanessa, Moreira, Roxana, Queirós, Odília, Carvalho, Félix, Dinis-Oliveira, Ricardo Jorge“…In the present study, we aimed to characterize the putative hepatic and renal deleterious effects of repeated exposure to therapeutic doses of tramadol and tapentadol, using an in vivo animal model. …”
Publicado 2020
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98102por Suga, Takayoshi, Sato, Ken, Ohyama, Tatsuya, Matsui, Sho, Kobayashi, Takeshi, Tojima, Hiroki, Horiguchi, Norio, Yamazaki, Yuichi, Kakizaki, Satoru, Nishikido, Ayaka, Okamura, Takashi, Yamada, Masanobu, Kitamura, Tadahiro, Uraoka, Toshio“…SGLT2 is primarily expressed in the kidneys and reabsorbs approximately 90% of the glucose filtered by the renal glomeruli. SGLT2 inhibitors lower glucose levels independently of insulin action by facilitating urinary glucose excretion. …”
Publicado 2020
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98103por López-Mínguez, José Ramón, Nogales-Asensio, Juan Manuel, Infante De Oliveira, Eduardo, Santos, Lino, Ruiz-Salmerón, Rafael, Arzamendi-Aizpurua, Dabit, Costa, Marco, Gutiérrez-García, Hipólito, Fernández-Díaz, Jose Antonio, Freixa, Xavier, Cruz-González, Ignacio, Moreno, Raúl, Íñiguez-Romo, Andrés, Alfonso-Manterola, Fernando“…The occurrence of thromboembolic and bleeding events was compared to rates expected from CHA2DS2-VASc (congestive heart failure, hypertension, age, diabetes, stroke history, vascular disease, sex) and HAS-BLED (hypertension, abnormal renal and liver function, stroke, bleeding, labile INR, elderly, drugs or alcohol) scores. …”
Publicado 2020
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98104por Lammerts, Rosa G. M., Talsma, Ditmer T., Dam, Wendy A., Daha, Mohamed R., Seelen, Marc A. J., Berger, Stefan P., van den Born, Jacob“…Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. …”
Publicado 2020
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98105por Merle, Nicolas S., Leon, Juliette, Poillerat, Victoria, Grunenwald, Anne, Boudhabhay, Idris, Knockaert, Samantha, Robe-Rybkine, Tania, Torset, Carine, Pickering, Matthew C., Chauvet, Sophie, Fremeaux-Bacchi, Veronique, Roumenina, Lubka T.“…Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master complement regulator Factor H (FH) in the kidney's resistance to hemolysis-mediated AKI. …”
Publicado 2020
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98106por Young, Michael N., Kolte, Dhaval, Cadigan, Mary E., Laikhter, Elizabeth, Sinclair, Kevin, Pomerantsev, Eugene, Fifer, Michael A., Sundt, Thoralf M., Yeh, Robert W., Jaffer, Farouc A.“…Prevalent comorbidities included diabetes mellitus (51.8%), peripheral artery disease (38.6%), atrial fibrillation (27.1%), end‐stage renal disease on dialysis (13.3%), and chronic obstructive pulmonary disease (21.7%). …”
Publicado 2020
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98107“…The method was developed as an alternative to hemodialysis (HD) presenting a patient survival rate equivalent to HD and better preservation of residual renal function. Peritoneal dialysis (PD) patients have different peritoneal membrane permeability (transport) characteristics. …”
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98108por Hounkpatin, Hilda O, Harris, S, Fraser, Simon D S, Day, Julie, Mindell, Jennifer S, Taal, Maarten W, O'Donoghue, Donal, Roderick, Paul J“…PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) and albuminuria (measured by albumin–creatinine ratio) during 2009/2010 and 2016 and trends in eGFR between 2003 and 2016. eGFR was estimated using serum creatinine Chronic Kidney Disease Epidemiology Collaboration and Modification of Diet in Renal Disease equations. RESULTS: GFR <60 mL/min/1.73 m(2) prevalence was 7.7% (95% CI 7.1% to 8.4%), 7.0% (6.4% to 7.7%) and 7.3%(6.5% to 8.2%) in 2003, 2009/2010 and 2016, respectively. …”
Publicado 2020
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98109por Hurkmans, Evelien G. E., Klumpers, Marije J., Vermeulen, Sita H., Hagleitner, Melanie M., Flucke, Uta, Schreuder, H. W. Bart, Gelderblom, Hans, Bras, Johannes, Guchelaar, Henk-Jan, Coenen, Marieke J. H., te Loo, D. Maroeska W. M.“…Methotrexate plasma levels and laboratory measurements during and after high-dose methotrexate treatment concerning renal function, liver damage, and myelopoiesis to reflect toxicity outcomes were obtained. …”
Publicado 2020
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98110por Nallasamy, Karthi, Gupta, Shalu, Bansal, Arun, Biswal, Manisha, Jayashree, Muralidharan, Zaman, Kamran, Williams, Vijai, Kumar, Abhay“…Intensive care needs include invasive ventilation (n = 27, 17%), vasoactive drugs therapy for hemodynamic support (n = 43, 27%), osmotherapy to treat raised intracranial pressure (n = 27, 17%), and renal replacement therapy (n = 3, 2%). Mortality was 8.8%. …”
Publicado 2020
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98111por Mukherjee, Vikramjit, Toth, Alexander T., Fenianos, Madelin, Martell, Sarah, Karpel, Hannah C., Postelnicu, Radu, Bhatt, Alok, Deshwal, Himanshu, Kreiger-Benson, Elana, Brill, Kenneth, Goldlust, Sandra, Nair, Sunil, Walsh, B. Corbett, Ellenberg, David, Magda, Gabriela, Pradhan, Deepak, Uppal, Amit, Hena, Kerry, Chitkara, Nishay, Alviar, Carlos L., Basavaraj, Ashwin, Luoma, Kelsey, Link, Nathan, Bails, Douglas, Addrizzo-Harris, Doreen, Sterman, Daniel H.“…One-hundred twenty-one of 137 (78.1%) required mechanical ventilation of whom 30 (24.8%) moved to tracheostomy and 46 of 137 (33.6%) required new onset renal replacement therapy. Eighty-two of 137 patients (59.9%) died after a median of 8 days (interquartile range 5–15 d) in the ICU. …”
Publicado 2020
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98112“…CONCLUSIONS: There were no independent positive associations between CKD and specific TOAST subtypes, which suggest that renal-specific risk factors are unlikely to play an important role in the etiology of particular subtypes. …”
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98113“…The improvements in outcomes resulted in an estimated reduction of more than 1.2 million complications cumulatively over 25 years, of which more than 550,000 relate to diabetic foot and more than 170,000 related to renal disease. CONCLUSION: Over a 25 year period, Spain could considerably reduce costs and avoid major complications if, on a population level, more ambitious glycaemic control, according to Spanish or EU guidelines, could be achieved among people with type 2 diabetes by reducing the HbA1c threshold for treatment intensification. …”
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98114por Cao, Jiatian, Zheng, Yan, Luo, Zhe, Mei, Zhendong, Yao, Yumeng, Liu, Zilong, Liang, Chao, Yang, Hongbo, Song, Yanan, Yu, Kaihuan, Gao, Yan, Zhu, Chouwen, Huang, Zheyong, Qian, Juying, Ge, Junbo“…Methods: We included 244 COVID-19 patients, who were admitted to Renmin Hospital of Wuhan University with no preexisting cardiovascular disease or renal dysfunction. We analyzed the data including patients' clinical characteristics, cardiac biomarkers, severity of medical conditions, and 30-day in-hospital fatality. …”
Publicado 2020
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98115por Peer, Nasheeta, George, Jaya, Lombard, Carl, Steyn, Krisela, Levitt, Naomi, Kengne, Andre-Pascal“…GFR was based on the CKD Epidemiology Collaboration (CKD-EPI) equations (CKD-EPI creatinine (CKD-EPIcr), CKD-EPI cystatin C (CKD-EPIcys), CKD-EPI creatinine-cystatins (CKD-EPIcr-cys)), Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault formula (CGF). …”
Publicado 2020
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98116por Idilman, Ilkay S., Telli Dizman, Gulcin, Ardali Duzgun, Selin, Irmak, Ilim, Karcaaltincaba, Musturay, Inkaya, Ahmet Cagkan, Demirkazik, Figen, Durhan, Gamze, Gulsun Akpinar, Meltem, Ariyurek, Orhan Macit, Akpinar, Erhan, Rello, Jordi, Akova, Murat, Akata, Deniz“…D-dimer levels ≥ 0.485 μg/L predicted PD with 100% specificity and 87% sensitivity. Renal iodine maps showed heterogeneous enhancement consistent with perfusion abnormalities in 13 patients (50%) with lower sodium levels (p = 0.03). …”
Publicado 2020
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98117por Benza, Raymond L., Kanwar, Manreet K., Raina, Amresh, Scott, Jacqueline V., Zhao, Carol L., Selej, Mona, Elliott, C. Greg, Farber, Harrison W.“…STUDY DESIGN AND METHODS: REVEAL Lite 2 includes six noninvasive variables—functional class (FC), vital signs (systolic BP [SBP] and heart rate), 6-min walk distance (6MWD), brain natriuretic peptide (BNP)/N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and renal insufficiency (by estimated glomerular filtration rate [eGFR])—and was validated in a series of analyses (Kaplan-Meier, concordance index, Cox proportional hazard model, and multivariate analysis). …”
Publicado 2021
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98118“…Tests for liver function, renal function, lipid profile, serum osmolarity, thyroid function, c-peptide levels, and glycosylated hemoglobin were done on all patients. …”
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98119“…The increase of systemic exposure in non-dialysis patients with severe renal impairment was much less than that associated with nucleoside antiviral agents. …”
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98120“…BACKGROUND: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease; however, the underlying molecular mechanisms remain unclear. …”
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