“…The patient was previously being managed with vitamin D analogs, however, due to progression of her osteoporosis and systemic symptoms despite normal renal function after the transplant, decision was made to proceed for surgical intervention. …”
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“…Hypertension and hypokalemia likely reflect saturation of renal 11-β-hydroxysteroid dehydrogenase with excess cortisol, though the patient lacked the features of rapidly progressive Cushing’s syndrome described in many cases of cortisol secreting ACC. …”
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“…She had no history of renal disease and no family history of parathyroid disorders. …”
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“…Exclusion criteria included genetic syndromes, renal failure, recent immunosuppressant or steroid use and small for gestational age. …”
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“…Secondary Hyperparathyroidisim in chronic renal failure: A systematic review and meta-analysis. …”
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“…Patient was treated aggressively with intravenous fluids, calcitonin subcutaneously and pamidronate 60 mg intravenous infusion, given the depressed renal function. The total calcium level decreased to 10.9 mg/dL [8.9-10.4 mg/dL]. …”
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“…Denosumab is useful for management of PHPT regardless of renal function.…”
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“…She was also noted to have pre-renal acute kidney injury. Upon questioning, she recently started a “carnivore diet” in which she cut her carbohydrate intake to near zero. eDKA was treated with an IV insulin DKA protocol. …”
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“…Presenting with increased muscular mass (pseudohypertrophy), proximal muscle weakness, stiffness, and cramping it may be complicated by renal failure and ATN. Calf muscles are typically affected in Hoffman’s; however, patient presented postpartum with proximal upper limb involvement. …”
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“…Concerning features for possible parathyroid carcinoma included the patient’s young age, a corrected calcium level >14 mg/dL, a markedly elevated PTH, a parathyroid mass >3 cm, and the combination of renal and bone involvement.(1) These factors prompted the resection of adjacent lymph nodes with the parathyroid mass. …”
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“…One of the 3 carriers had a history of elevated parathyroid hormone levels and renal calculi without hypercalcemia. Two of the 3 carriers had a documented family history of MEN2A. …”
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“…On this admission, hospital course was complicated by disseminated intravascular coagulation, acute kidney injury needing renal replacement therapy (RRT), encephalopathy, and mechanical ventilation. …”
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“…PTH-independent causes of hypercalcemia were unremarkable for humoral hypercalcemia of malignancy (PTHrP 0.2pmol/L, n <2.0pmol/L), vitamin D toxicity (24-hydroxyvitamin D 41ng/mL, n 30-80ng/mL), granulomatous disorders (1,25-dihydroxyvitamin D 24.8pg/mL, n 19.9-79.3pg/mL; quantiferon negative), hyperthyroidism, and adrenal insufficiency. Renal function was normal and there was no thiazide, lithium, calcium, or vitamin A use. …”
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“…Additional lab testing showed ionized calcium 0.79 mmol/L (n 1.1-1.35), phosphorus 8.7 mg/dL (n 2.9-5.1), PTH 439 pg/mL (n 10.0-65.0), alkaline phosphatase (ALP) 308 U/L (n 60-270) and 25-hydroxy vitamin D 25.8 ng/mL (n 30-83). Renal function was normal. Findings were suggestive of PTH resistance. …”
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“…Methods: To further investigate the frequency of marked MTN elevations in HTNE, we retrospectively studied the results of PMTN and UMTN measurements in 48 patients (59.7±15.6 years; 48% female; BMI: 31±9.7 kg/m(2)) hospitalized for HTNE, with end-organ damage manifesting either as encephalopathy (19%), stroke (30%), congestive heart failure (CHF; 54%), myocardial ischemia (MI; 17%), or acute renal injury (AKI; 31%). PMN and PNMN were measured in 47 patients, UMN and UNMN were measured in 16 patients and 15 patients had both PMTN and UMTN measured. …”
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“…Often described as low-renin hypertension, PA is a major public health concern given its prevalence and associated cardiovascular and renal pathology. Compared to patients with essential hypertension, patients with PA are at greater risk for stroke, coronary artery disease, atrial fibrillation, and heart failure. …”
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“…Expression of ADCY2 in the GU tract was localized to renal tubules, bladder muscle, urethra, and interstitial cells of the testis with the highest expression in the testes. …”
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“…Patients were grouped according to the status of renal damage as AKI (n = 33) or non-AKI (n = 19). …”
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“…Participants will be randomly assigned to receive either TZP by continuous infusion guided by daily TDM of piperacillin (experimental group) or by continuous infusion without TDM guidance (total daily dose in normal renal function 13.5 g TZP) (control group). The pharmacokinetic (PK)/pharmacodynamic (PD) target will be 100% f T(>4MIC) (percentage of time during a dosing interval that the free [f] drug concentration exceeds 4 times the minimum inhibitory concentration). …”
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“…Conclusion: Our data support our hypothesis that inappropriately activated MR signaling mediates the cardio-renal defects in the LSD1 deficient mouse. These findings support the concept that treatment with an MR antagonist may result in improved cardio- and reno-vascular outcomes in human LSD1(+/-) risk allele carriers.…”
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