“…Background: Specific safety issues with sodium-glucose co-transporter-2 (SGLT2) inhibitors such as infection, fractures, worsening of renal function and euglycemic ketoacidosis have been raised. …”
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“…Clinical response rates were similar between treatment groups, regardless of age (≤ 65 years or > 65 years), and in subgroups of patients with and without diabetes mellitus, peripheral vascular disease, cancer/malignancy, renal impairment, and obesity; within these subgroups, efficacy and safety results were generally consistent with those of the overall cSSTI population. …”
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“…Patients with end-stage renal disease develop changes in bone quality and quantity, which can be assessed using different methods. …”
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“…Macrovascular events (hospitalization for heart failure, myocardial infarction, stroke, and unstable angina), end-stage renal disease and cardiovascular and non-cardiovascular mortality were modeled according to the survival equations of the DECLARE-TIMI 58 study. …”
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“…RESULTS: A 61-year-old man with a medical history of myasthenia gravis, chronic obstructive pulmonary disease, hypothyroidism, and chronic renal failure was treated in our establishment for a SARS-CoV-2 pneumonia. …”
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“…T50 assays and other biochemical assays were funded by a research grant from Sanofi Renal Corporation. TRIAL REGISTRATION: NCT00745589.…”
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“…We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m(6)A-RNA methylation (epitranscriptomic) regulators (m(6)A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m(6)A-RMRs were upregulated; and most m(6)A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m(6)A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m(6)A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m(6)A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m(6)A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m(6)A-RMRs the most among viral infections; (6) proinflammatory oxPAPC modulated m(6)A-RMRs more than DAMP stimulation including LPS and oxLDL; (7) upregulated m(6)A-RMRs were more than downregulated m(6)A-RMRs in cancer types; five types of cancers upregulated ≥10 m(6)A-RMRs; (8) proinflammatory M1 macrophages upregulated seven m(6)A-RMRs; (9) 86% of m(6)A-RMRs were differentially expressed in the six clusters of CD4(+)Foxp3(+) immunosuppressive Treg, and 8 out of 12 Treg signatures regulated m(6)A-RMRs; (10) immune checkpoint receptors TIM3, TIGIT, PD-L2, and CTLA4 modulated m(6)A-RMRs, and inhibition of CD40 upregulated m(6)A-RMRs; (11) cytokines and interferons modulated m(6)A-RMRs; (12) NF-κB and JAK/STAT pathways upregulated more than downregulated m(6)A-RMRs whereas TP53, PTEN, and APC did the opposite; (13) methionine-homocysteine-methyl cycle enzyme Mthfd1 downregulated more than upregulated m(6)A-RMRs; (14) m(6)A writer RBM15 and one m(6)A eraser FTO, H3K4 methyltransferase MLL1, and DNA methyltransferase, DNMT1, regulated m(6)A-RMRs; and (15) 40 out of 165 ROS regulators were modulated by m(6)A eraser FTO and two m(6)A writers METTL3 and WTAP. …”
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“…Patients with mOHS had a significantly higher rate of heart failure (100% vs. 31%; p < 0.001), chronic renal insufficiency (CRI) (73.3% vs. 41.4%; p = 0.04), and dyslipidemia (66.7% vs. 34.5%; p = 0.04) than those with non-mOHS. …”
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“…However, men had more coronary heart disease, chronic renal disease, COPD, and obstructive sleep apnea. …”
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“…Unnecessary deep anesthesia can be harmful, potentially causing acute renal failure, myocardial injury, delirium, and an increased mortality rate. …”
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“…We found that the serum MIF levels [median, (interquartile range)] were significantly (p < 0.001) elevated in different clinical forms of leptospirosis, such as febrile illness [7.5 ng/ml (5.32–8.97)], pulmonary hemorrhage [13.2 ng/ml (11.77–16.72)], Weil’s syndrome [8.8 ng/ml (7.25–9.95)], and renal failure [8.6 ng/ml (7.18–10.5)], than in healthy controls [0.65n g/ml (0.5–1.1)]. …”
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“…GFR by Schwartz formula was reduced in all cases (1,7-58,1 ml/min/1,73 m(2)). 3 had anuria, 2 oliguria. Renal replacement therapy (RRT) performed in 5 cases: 3 hemodiafiltration (HDF) only; 2 - HDF + plasma exchange (1 - 7 procedures). …”
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“…Biochemical analysis and renal histology confirmed the successful establishment of the CS-AKI mouse model. …”
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“…MR analyses revealed no causal relationships between α-Klotho and renal function, FGF23-dependent factors such as vitamin D and phosphate levels, or bone mineral density. …”
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“…HMOD was defined as the presence of carotid intima-media thickness (IMT) above normal values and/or carotid plaque, left ventricular hypertrophy (LVH), and/or renal abnormalities as assessed by urine albumin/creatinine ratio above normal values and/or estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m(2). …”
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“…For the second aim, we applied analysis of covariance (ANCOVA), change score, propensity score and the naïve approach (ignores the baseline outcome data) in IPD-MA from NRSs on the association between subclinical hyperthyroidism and depressive symptoms and renal function. We estimated the study and meta-analytic mean difference (MD) and relative standard error (SE). …”
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“…One patient with 3 channels was given renal artery interventional embolization for control of postoperative bleeding. …”
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“…RESULTS: Gb3 was significantly increased in cultured human renal proximal tubular epithelial cells (HK-2) and human podocytes following the siRNA silencing of α galactosidase A (α-GLA). …”
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“…METHODS: This is a multicenter phase IB dose-escalation study of the combination of ziv-aflibercept (at 2–4 mg/kg) plus pembrolizumab (at 2 mg/kg) administered intravenously every 2 weeks with expansion cohorts in programmed cell death protein 1 (PD-1)/programmed death-ligand 1(PD-L1)-naïve melanoma, renal cell carcinoma (RCC), microsatellite stable colorectal cancer (CRC), and ovarian cancer. …”
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“…The logistic regression analysis showed that the risk factors for in-hospital mortality were elevated levels of lactic dehydrogenase and high-sensitivity troponin I, acute renal failure, COPD, and > 10 points on the MuLBSTA score. …”
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