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101201por Spinner, Christoph D, Rashbaum, Bruce, Mcdonald, Cheryl, Mussini, Cristina, Luo, Donghan, Jezorwski, John, Brown, Kimberley, Wong, Eric Y“…In the pivotal AMBER trial in antiretroviral treatment (ART)-naïve, HIV-1–infected adults, D/C/F/TAF achieved a high virologic response rate at Week 48 that was noninferior to control (D/C+F/tenofovir disoproxil fumarate); favorable renal/bone outcomes were seen with D/C/F/TAF vs. control. …”
Publicado 2018
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101202por Tang, Bixia, Yan, Xieqiao, Sheng, Xinan, Si, Lu, Cui, Chuanliang, Kong, Yan, Mao, Lili, Lian, Bin, Bai, Xue, Wang, Xuan, Li, Siming, Zhou, Li, Yu, Jiayi, Dai, Jie, Wang, Kai, Hu, Jinwei, Dong, Lihou, Song, Haifeng, Wu, Hai, Feng, Hui, Yao, Sheng, Chi, Zhihong, Guo, Jun“…RESULTS: Thirty-six subjects diagnosed with advanced melanoma (n = 22), urothelial cancer (UC) (n = 8), or renal cell cancer (RCC) (n = 6) were enrolled. Melanoma subjects included 14 acral and 4 mucosal subtypes. …”
Publicado 2019
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101203por Lau, Joseph, Rousseau, Etienne, Zhang, Zhengxing, Uribe, Carlos F., Kuo, Hsiou-Ting, Zeisler, Jutta, Zhang, Chengcheng, Kwon, Daniel, Lin, Kuo-Shyan, Bénard, François“…Imaging/biodistribution studies showed that the excretion of [(68)Ga]Ga-ProBOMB1 was primarily through the renal pathway. At 1 h postinjection (p.i.), PC-3 tumor xenografts were clearly delineated in PET images with excellent contrast. …”
Publicado 2019
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101204por He, Junyu, Christakos, George, Wu, Jiaping, Jankowski, Piotr, Langousis, Andreas, Wang, Yong, Yin, Wenwu, Zhang, Wenyi“…BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is a zoonosis caused by hantavirus (belongs to Hantaviridae family). …”
Publicado 2019
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101205por Nolte, Kathleen, Herrmann‐Lingen, Christoph, Platschek, Lars, Holzendorf, Volker, Pilz, Stefan, Tomaschitz, Andreas, Düngen, Hans‐Dirk, Angermann, Christiane E., Hasenfuß, Gerd, Pieske, Burkert, Wachter, Rolf, Edelmann, Frank“…At baseline, participants with 25(OH)D levels in the lowest tertile (≤10.9 ng/L; n = 263) were older, more often symptomatic (oedema and fatigue, all P ≤ 0.002) and had worse cardiac [higher N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and left atrial volume index, both P ≤ 0.023], renal (lower glomerular filtration rate, P = 0.012), metabolic (higher uric acid levels, P < 0.001), and functional (reduced exercise capacity, 6 min walk distance, and SF‐36 physical functioning score, all P < 0.001) parameters. …”
Publicado 2019
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101206por Honvo, Germain, Reginster, Jean-Yves, Rannou, Francois, Rygaert, Xavier, Geerinck, Anton, Rabenda, Véronique, McAlindon, Tim, Charles, Alexia, Fuggle, Nicholas, Cooper, Cyrus, Curtis, Elizabeth, Arden, Nigel, Avouac, Bernard, Bruyère, Olivier“…The primary outcomes were overall severe and serious AEs, as well as the following MedDRA System Organ Class (SOC)-related AEs: gastrointestinal, cardiac, vascular, respiratory, nervous system, skin and subcutaneous tissue disorders, musculoskeletal, renal and urinary disorders, infections and infestations, and hypersensitivity reaction. …”
Publicado 2019
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101207por Gurung, Resham L., Yiamunaa, M., Liu, Sylvia, Liu, Jian Jun, Chan, Clara, Choo, Robin Wai Munn, Ang, Keven, Sum, Chee Fang, Tavintharan, Subramaniam, Lim, Su Chi“…In meta-analysis, presence of Hp 1 allele conferred 43% (hazard ratio [HR] = 1.43 [95% CI 1.10–1.87], P = 0.008, P(het) = 0.413) increased risk of incident AMI, independent of age, sex, smoking, body mass index, HbA1c, diabetes duration, lipids, hypertension, renal function and usage of insulin and RAS antagonist. …”
Publicado 2019
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101208por Zanchetta, Maria, Giacoia, Evangelina, Robbiani, Damian, Galich, Ana, Kallsbrum, Silvia, Frigeri, Adriana, Salerni, Helena, Perez, Betiana, Diaz, Adriana, Lucas, Sabrina, Grandjean, Matias, Kitaigrodsky, Mariela, Tormo, S., Oliveri, Beatriz“…Non-surgical patients were significantly younger (45 ± 19.5 vs.56.3 ± 16.1 years; p<0.01) and were younger at diagnosis (45.1 ± 15.9 vs. 31.4 ± 20.5 years;p<0.01).Treatment regimens were determined by the patients’ physician, per usual clinical practice, and most patients were receiving calcium supplementation (mean daily dose:2019 ± 1426 mg), vitamin D ( mean weekly dose 34.368 ± 55.278 UI) and calcitriol ( mean daily dose: 0.498 ± 0.279 mcg). 13 patients were receiving teriparatide ( 1-34 human parathyroid hormone). 25.7% had a history of hypocalcemia requiring hospitalization, 4.6% had fragility fracture history (wrist, hip, humerus, vertebra or tibia) and 4.3% has a history of seizures. Only 41.9% had a renal ultrasound done and 15.5 % had positive findings ( kidney stones and nephrocalcinosis). 54% had 24-hour urine calcium excretion measured and almost half of them had hypercalciuria confirmed (56.3%). …”
Publicado 2019
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101209por Meyreles Chaljub, Gustavo, Torres Potter, Losty, Troya, Pedro, Candelario-Cosme, Madeline, Weare-Regales, Natalia“…Initial labs showed normal CBC, low sodium (125, n 135 - 148 MEQ/L), hyperkalemia (5.8, n 3.5 - 5.3 MEQ/L), normal blood glucose and renal function. Further testing showed low AM cortisol <1.0 ug/dL (n 6.7-22.6 ug/dL), high ACTH (1010, n 6-50pg), TSH 7 (n 0.35 - 4.94 UIU/ML), Free T4 0.70 (n 0.70 - 1.48 NG/DL), TPO antibodies 759.06 (n<5.61 IU/ML), low aldosterone level <1.0 (n 3 - 16 ng/dL), and high renin activity 19.53 (n 0.25 - 5.82 ng/mL/h). …”
Publicado 2019
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101210por Hannan, Fadil, Stokes, Victoria, Gorvin, Caroline, Hough, Tertius, Codner, Gemma, Stewart, Michelle, Wells, Sara, Teboul, Lydia, Thakker, Rajesh“…Thus, these studies have established a mouse model for FHH3, which highlights the importance of the AP2σ protein in the parathyroid and renal regulation of mineral and bone homeostasis. …”
Publicado 2019
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101211“…An EKG showed normal sinus rhythm and normal QTc. Renal US showed bilateral medullary nephrocalcinosis. …”
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101212“…However, clinical course then rapidly deteriorated with transformation into acute leukemia with hemophagocytic lymphohistiocytosis (HLH), tumor lysis syndrome, septic shock, and acute renal failure. Venous ionized Ca levels dropped to 0.80 mmol/L (n: 1.14-1.29 mmol/L) six days after denosumab dose. …”
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101213“…Subjects with end stage renal disease, bariatric surgery, Paget’s disease, and organ transplantation were excluded. …”
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101214por Smith, Pamela, Bayliss, Susan, Shinawi, Marwan, Gottesman, Gary, McAlister, William, Sugarman, Jeffrey, Whyte, Michael, Arbelaez, Ana Maria“…CSHS features: 1) congenital epidermal, melanocytic, or sebaceous nevi, 2) elevated circulating FGF23 levels that cause renal phosphate wasting and skeletal hypomineralization, and 3) focal bone lesions ipsilateral to the nevi as a possible source of excess FGF23. …”
Publicado 2019
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101215“…A 26-year old male with metastatic renal cell carcinoma was started on treatment with the anti-programmed cell death 1 (PD-1) monoclonal antibody nivolumab. …”
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101216“…Other important differential diagnoses of simultaneous anterior and posterior pituitary deficiencies with simultaneous hypothalamic and pituitary lesions include malignancies such as craniopharyngioma, metastatic melanoma, renal cell carcinoma and germ cell tumors; and infiltrative diseases such as sarcoidosis, IgG4-related hypophysitis, amyloidosis, and hemochromatosis.…”
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101217“…Were excluded: pregnant, prediabetes or T2DM previous, in hyperglycemic crisis, any thyroid disease including goiter, renal failure, chronic liver disease, heart failure or hypoalbuminemia and lost weight in the last 3 months. …”
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101218por Dadlani, Vikash, Kumari, Kanchan, Thapa, Prabin, Dean, Patrick, Stegall, Mark, Kudva, Yogish“…Pancreas transplantation (PT) is performed in certain individuals with T1D with and without and end-stage renal disease. To date, GV before and after PT has been examined to a limited extent and the optimal times to assess glucose control after PT has not been evaluated. …”
Publicado 2019
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101219“…Abdominal pain, (64% in group 1 and 38% in group 2), vomiting, (36% in group 1 and 30.8% in group 2), dehydration (16% in group 1 and 15.4% in group 2), and hypomagnesemia (12% in group 1 and 15.4% in group 2) were the most common adverse effects in all patients, while patients who have received neoadjuvant chemotherapy were more likely to get hypokalemia, fatigue and renal insufficiency. Progression free survival (PFS) was 26.5 mo (95% CI 14.9, 38.0) in group 1 and 27.6 mo (95% CI 13.1, 42.1) in group 2. …”
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101220por Kinguchi, Sho, Wakui, Hiromichi, Ito, Yuzuru, Kondo, Yoshinobu, Azushima, Kengo, Osada, Uru, Yamakawa, Tadashi, Iwamoto, Tamio, Yutoh, Jun, Misumi, Toshihiro, Aoki, Kazutaka, Yasuda, Gen, Yoshii, Taishi, Yamada, Takayuki, Ono, Syuji, Shibasaki-Kurita, Tomoko, Hosokawa, Saho, Orime, Kazuki, Hanaoka, Masaaki, Sasaki, Hiroto, Inazumi, Kohji, Yamada, Taku, Kobayashi, Ryu, Ohki, Kohji, Haruhara, Kotaro, Kobayashi, Yusuke, Yamanaka, Takeharu, Terauchi, Yasuo, Tamura, Kouichi“…BACKGROUND: The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) and albuminuria. …”
Publicado 2019
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