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Mostrando 761 - 780 Resultados de 2,029 Para Buscar '"revolutionary"', tiempo de consulta: 0.15s Limitar resultados
  1. 761
    “…The repurposed CRISPR-Cas9 system has recently emerged as a revolutionary genome-editing tool. Here we report a modification in the expression of the guide (gRNA) required for targeting that greatly expands the targetable genome. gRNA expression through the commonly used U6 promoter requires a guanosine nucleotide to initiate transcription, thus constraining genomic targeting sites to GN(19)NGG. …”
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    Expansion of the CRISPR-Cas9 genome targeting space through the use of H1 promoter-expressed guide–RNAs
  2. 762
    por Han, Henry, Jiang, Xiaoqian
    Publicado 2014
    “…As a revolutionary way to unveil transcription, RNA-Seq technologies are challenging bioinformatics for its large data volumes and complexities. …”
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    Disease Biomarker Query from RNA-Seq Data
  3. 763
    por Doll, Sophia, Burlingame, Alma L.
    Publicado 2014
    “…Here, we provide an update of MS-based PTM analyses, with a focus on current enrichment strategies coupled with revolutionary advances in high performance MS. Furthermore, we discuss examples of the discovery of recently described biological roles of PTMs and address the challenges of defining site-specific functions.…”
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    Mass Spectrometry-Based Detection and Assignment of Protein Posttranslational Modifications
  4. 764
    “…Phase 3 clinical trials with belimumab have depicted clinically efficacious applications, suggesting belimumab as a revolutionary breakthrough in the treatment armamentarium for practicing clinicians. …”
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    Efficacy of novel monoclonal antibody belimumab in the treatment of lupus nephritis
  5. 765
    “…Despite considerable progress in understanding the molecular biology of distinct cancer entities by the use of this revolutionary technology and despite contemporaneous innovations in drug development, translation of NGS findings into improved concepts for cancer treatment remains a challenge. …”
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    Next-generation sequencing: hype and hope for development of personalized radiation therapy?
  6. 766
    “…For common disabling diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), recent developments have seen revolutionary nanotech-based novelties, which are discussed here in detail. …”
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    Nanotechnology in neurology: Genesis, current status, and future prospects
  7. 767
    “…Single-particle structure recovery without crystals or radiation damage is a revolutionary possibility offered by X-ray free-electron lasers, but it involves formidable experimental and data-analytical challenges. …”
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    Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges
  8. 768
    “…Optogenetics is a revolutionary technique that enables noninvasive activation of electrically excitable cells. …”
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    Optogenetic stimulation of Drosophila heart rate at different temperatures and Ca(2+) concentrations
  9. 769
    “…The demonstrated results promise OLAG as a revolutionary tool in the clinical research and treatment of patients with pathologic conditions such as cancer, diabetes, and autoimmune diseases.…”
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    OCT-based label-free in vivo lymphangiography within human skin and areola
  10. 770
    “…Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis, endocrinopathies and nephritis. …”
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    Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma
  11. 771
    “…The impact of the Ilizarov method on the progress of bone lengthening and reconstruction surgery could be called revolutionary.…”
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    Contribution of G.A. Ilizarov to bone reconstruction: historical achievements and state of the art
  12. 772
    por Ahmad, Mahmoud Al
    Publicado 2016
    “…In this paper, the revolutionary generation and extraction of the corresponding ECG signal using a piezoelectric transducer as alternative for the ECG will be discussed. …”
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    Piezoelectric extraction of ECG signal
  13. 773
    por Donnelly, Mary
    Publicado 2016
    “…It also argues that the best interests standard in the Mental Capacity Act retains some revolutionary potential and that, pending legislative reform, this can be further developed through the courts.…”
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    Best Interests in the Mental Capacity Act: Time to say Goodbye?
  14. 774
    por Nam, Seungyoon
    Publicado 2017
    “…Essentially, these revolutionary changes demand new interpretations of huge datasets at a systems-level, by so called “systems biology”. …”
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    Databases and tools for constructing signal transduction networks in cancer
  15. 775
    “…The development of new revolutionary technologies for directed gene editing has made it possible to thoroughly model and study NgAgo human diseases at the cellular and molecular levels. …”
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    Modern Genome Editing Technologies in Huntington’s Disease Research
  16. 776
    por Harayama, Takeshi, Riezman, Howard
    Publicado 2017
    “…Genome editing by the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats / CRISPR-associated protein 9) system is a revolutionary strategy to study gene functions. Since the efficiency of gene disruption in cell culture does not reach 100% typically, cloning of mutant cells is often performed to obtain fully mutated cells. …”
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    Detection of genome-edited mutant clones by a simple competition-based PCR method
  17. 777
    por Liebowitz, Dan
    Publicado 2017
    “…During theAmerican Revolutionary war, smallpox outbreaks were impeding the American war effort until1777 when George Washington carried out a mass inoculation campaign in the ContinentalArmy that reduced the mortality from smallpox to less than 2%. …”
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    Smallpox vaccination: an early start of modern medicine in America
  18. 778
    “…METHODS: With several studies demonstrating its simplicity, efficacy and safety this revolutionary method, paved the way for new therapies and strategies in the treatment of corneal ectatic diseases and changed our understanding in corneal biomechanics. …”
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    Recent Innovations in Collagen Corneal Cross-linking; a Mini Review
  19. 779
    por Ovallath, Sujith, Sulthana, Bahiya
    Publicado 2017
    “…So as a token of gratitude to the revolutionary agent and pioneers behind it, a trip down the memory lane is in order.…”
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    Levodopa: History and Therapeutic Applications
  20. 780
    por Zwigenberg, Ran
    Publicado 2018
    “…This research and the perceived revolutionary impact of atomic energy and warfare on society, this paper argues, played an important role in the global development of post-war psychiatry. …”
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    Healing a Sick World: Psychiatric Medicine and the Atomic Age
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