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  1. 1501
    “…The discovery of aquaporin-4 (AQP4) antibody as a highly specific marker responsible for the pathogenesis of NMO, not only has made a revolutionary pace in establishing a serologic distinction between the two diseases, but it has also classified NMO as an antibody-mediated disorder. …”
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    Myasthenia Gravis during the Course of Neuromyelitis Optica
  2. 1502
    “…High-throughput next-generation sequencing provides a revolutionary platform to unravel the precise DNA aberrations concealed within subgroups of tumour cells. …”
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    Mate Pair Sequencing of Whole-Genome-Amplified DNA Following Laser Capture Microdissection of Prostate Cancer
  3. 1503
    Publicado 2013
    “…These features combined make it a potentially revolutionary development in obstetrics, particularly for improving intrapartum care and reducing maternal and perinatal morbidity and mortality in low resource settings. …”
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    Feasibility and safety study of a new device (Odón device) for assisted vaginal deliveries: study protocol
  4. 1504
    por Barcaccia, Gianni, Albertini, Emidio
    Publicado 2013
    “…The development of apomixis technology is expected to have a revolutionary impact on agricultural and food production by reducing cost and breeding time, and avoiding the complications that are typical of sexual reproduction (e.g., incompatibility barriers) and vegetative propagation (e.g., viral transfer). …”
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    Apomixis in plant reproduction: a novel perspective on an old dilemma
  5. 1505
    “…BACKGROUND: The understanding and management of neurological disorders is undergoing revolutionary changes over the last three decades in the background of ever increasing advances in medical technologies, diagnostic techniques, therapeutic processes and, molecular and genetic medicine. …”
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    Etiological beliefs of patients with neurological disorders attending a tertiary care center: A cross-sectional study
  6. 1506
    por Browne, Caroline A., Lucki, Irwin
    Publicado 2013
    “…Recent evidence from clinical trials shows that the NMDA antagonist ketamine is a revolutionary novel antidepressant because it acts rapidly and is effective for treatment-resistant patients. …”
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    Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
  7. 1507
    “…BACKGROUND: Real-time polymerase chain reaction (PCR) is based on the revolutionary method of PCR. This technique is the result of PCR enormous sensitivity and real-time monitoring combination. …”
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    Comparison of SYBR Green and TaqMan methods in quantitative real-time polymerase chain reaction analysis of four adenosine receptor subtypes
  8. 1508
    “…Recently, induced pluripotent stem cells (iPSCs) were established as promising cell sources for revolutionary regenerative therapies. The initial culture system used for iPSC generation needed fetal calf serum in the culture medium and mouse embryonic fibroblast as a feeder layer, both of which could possibly transfer unknown exogenous antigens and pathogens into the iPSC population. …”
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    Derivation of Transgene-Free Human Induced Pluripotent Stem Cells from Human Peripheral T Cells in Defined Culture Conditions
  9. 1509
    “…All-trans retinoic acid (ATRA) is a revolutionary agent for acute promyelocytic leukemia (APL) treatment via differentiation induction. …”
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    Celastrol Inhibits Lung Infiltration in Differential Syndrome Animal Models by Reducing TNF-α and ICAM-1 Levels while Preserving Differentiation in ATRA-Induced Acute Promyelocytic Leukemia Cells
  10. 1510
    “…When accompanied with a high-throughput sequencing platform, we forecast their potential revolutionary impacts on evolutionary and ecological research, which may offer an exciting prospect for connecting the gap between DNA sequence and phenotype in the near future.…”
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    Advances in genome editing technology and its promising application in evolutionary and ecological studies
  11. 1511
    por Meloni, Maurizio, Testa, Giuseppe
    Publicado 2014
    “…Its rise is frequently framed as a revolutionary turn that heralds a new epoch both for gene-based epistemology and for the wider discourse on life that pervades knowledge-intensive societies of the molecular age. …”
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    Scrutinizing the epigenetics revolution
  12. 1512
    “…The application of phenomics and the phenome-wide associated study (PheWAS) will not only identify a systemically-integrated set of biomarkers for diagnosis and prognosis of vascular disease but also provide novel treatment targets for combination therapy and thus make a revolutionary paradigm shift in the clinical treatment of these devastating diseases.…”
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    Phenomics of Vascular Disease: The Systematic Approach to the Combination Therapy
  13. 1513
    “…As such, numerous methods have focused on studying tRNA abundance and regulation, with the most widely used methods being RNA-seq and microarrays. Though revolutionary to transcriptomics, these assays are limited by an inability to encode tRNA modifications in the requisite cDNA. …”
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    Capture, Unfolding, and Detection of Individual tRNA Molecules Using a Nanopore Device
  14. 1514
    “…Platelet transfusions have contributed to the revolutionary modern treatment of hypoproliferative thrombocytopenia. …”
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    Current trends in platelet transfusions practice: The role of ABO-RhD and human leukocyte antigen incompatibility
  15. 1515
    “…A macroscopic quantum object created by chemical doping that can persist to ambient temperature and resides in a bulk solid would be revolutionary in a number of scientific and technological fields.…”
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    Possible Demonstration of a Polaronic Bose-Einstein(-Mott) Condensate in UO(2(+x)) by Ultrafast THz Spectroscopy and Microwave Dissipation
  16. 1516
    “…As scoring systems like Glasgow Coma scale have made a revolutionary change in stratifying the patient, in particular, clinical scenario. …”
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    Evaluating efficacy of various operative procedures done in anterior urethral stricture using urethral stricture score
  17. 1517
    por Pyle, Richard L.
    Publicado 2016
    “…But the basic paradigm remains the same. Perhaps the most revolutionary change of all – which we are still in the midst of, and which has not yet been fully realized – is the means by which taxonomists manage and communicate the information of their trade. …”
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    Towards a Global Names Architecture: The future of indexing scientific names
  18. 1518
    “…It is an inexpensive, easy, most user friendly and rapidly adopted genome editing tool transforming to revolutionary paradigm. This technique enables precise genomic modifications in many different organisms and tissues. …”
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    The CRISPR/Cas Genome-Editing Tool: Application in Improvement of Crops
  19. 1519
    por Stößlein, Robert, Reuther, Falk
    Publicado 2016
    “…In our opinion LIGAMYS is a perfect and revolutionary additional method in treating ACL-ruptures before a plastic with hamstrings or ligament is needed.…”
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    1 Year LIGAMYS - our own results, examples and problems with this innovative new procedure in anterior cruciate ligament surgery
  20. 1520
    “…The most innovative approach is the use of small interfering RNAs (siRNAs) which represent a revolutionary new concept in human therapeutics. The nucleoprotein gene of RSV which is known as the most conserved gene and the M2/L mRNA, which encompass sixty-eight overlapping nucleotides, were selected as suitable targets for siRNA design. …”
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    Potential siRNA Molecules for Nucleoprotein and M2/L Overlapping Region of Respiratory Syncytial Virus: In Silico Design
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