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  1. 1761
    “…This work also highlights the possibility of detecting aberrant methylation profiles of circulating tumor DNA (ctDNA) through liquid biopsies, using the conventional methods, such as methylation-specific polymerase chain reaction (MS-PCR), sequencing methods, but also revolutionary methods, such as surface-enhanced Raman spectroscopy (SERS).…”
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  2. 1762
    “…Tyrosine kinase inhibitors (TKIs) are revolutionary drugs for the management of disease course in CML. …”
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  3. 1763
    “…While monoclonal antibodies (mAbs) targeting checkpoint receptors are revolutionary in cancer treatment, the immune-related adverse events (irAEs) may prevent their utilization in prophylactic and therapeutic treatments of infectious diseases. …”
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  4. 1764
    “…Meanwhile, machine and deep learning models have been revolutionary across numerous domains and applications whose potency have been exploited to birth numerous state-of-the-art technologies utilised in disease detection, diagnoses, and treatment. …”
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  5. 1765
  6. 1766
    “…Due to lack of clarity in its pathogenesis, a cure with existing treatment is a big challenge. Biologics, a revolutionary treatment, are potent immunomodulators that explicitly target the culprit cells of the immune system to achieve the maximum level of Psoriasis Area and Severity Index (PASI) score (75 to 90) and clear or almost clear skin in moderate to severe psoriasis. …”
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  7. 1767
    “…Although recent advances in targeted therapy and immunotherapy have brought revolutionary progress of the treatment outcome, the survival of patients with advanced melanoma remains unoptimistic, and metastatic melanoma is still an incurable disease. …”
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  8. 1768
    por Karenberg, Axel
    Publicado 2020
    “…While stroke basically remained a conundrum for many doctors and patients in early modern times (ca. 1500–1800; Platter, Wepfer), the revolutionary perception and definition of the disease as a result of a lesion in the 1810s (Rochoux, Rostan) opened the door to a productive relationship of the upcoming discipline “neurology” with the natural sciences during the nineteenth century and beyond (Virchow et al.). …”
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  9. 1769
    “…Graphene based van der Waals heterostructures (vdWHs) have gained substantial interest recently due to their unique electrical and optical characteristics as well as unprecedented opportunities to explore new physics and revolutionary design of nanodevices. However, the heat conduction performance of these vdWHs holds a crucial role in deciding their functional efficiency. …”
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  10. 1770
    por Zhang, Yu, Luo, Dan, Li, Jia, Li, Jisheng
    Publicado 2021
    “…The lack of methods has brought revolutionary advances in technology. The virtual surgery system based on collision detection and force feedback can enable the operator to have stronger interaction, which is an exploration of the feature of touch in virtual reality technology. …”
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  11. 1771
    “…BACKGROUND: The COVID-19 pandemic has rapidly led to some of the most revolutionary changes in private and professional life around the world. …”
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  12. 1772
    por Jeyaraj, Priya
    Publicado 2020
    “…INTRODUCTION: Distraction osteogenesis, has emerged as a revolutionary concept and an effective means to treat extensive craniomaxillofacial defects and malformations. …”
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  13. 1773
    “…However, the limitations of each of these methods, either performed in tandem or simultaneously, demonstrates the need of a revolutionary technology that can alleviate the need for multiple technologies. …”
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  14. 1774
    por Liu, Chang, Seeram, Navindra P., Ma, Hang
    Publicado 2021
    “…Programmed death-1/programmed death ligand-1 (PD-1/PD-L1) based immunotherapy is a revolutionary cancer therapy with great clinical success. …”
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  15. 1775
    “…In recent decades, treatments based on immune regulation have achieved revolutionary breakthroughs in cancer targeted therapies. …”
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  16. 1776
    “…However, the resistance mechanisms that promote the disease recurrence have altered the initial success of these revolutionary agents. PATIENT CONCERNS: A 71-year-old Chinese female patient who suffered from severe shoulder and back pain for 1 week. …”
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  17. 1777
    “…The utilization of biologically produced cells to treat diseases is a revolutionary invention in modern medicine after chemically synthesized small molecule drugs and biochemically made protein drugs. …”
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  18. 1778
  19. 1779
    “…The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic engineering, offers a promising platform to improve the treatment of various genetic and infectious diseases because of its simple design and powerful ability to edit different loci simultaneously. …”
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  20. 1780
    “…These therapeutics have led to revolutionary breakthroughs; however, the efficacy of immunotherapy has been modest and is often restricted to a subset of patients. …”
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