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  1. 1921
    “…However, since genetic material carries genetic information, the “source code” of all living activities, it is actually reasonable to question the plausibility of such a “revolutionary” transition. Due to our inability to model relevant “primitive living systems” in reality, it is as yet impossible to explore the plausibility and mechanisms of the “genetic takeover” by experiments. …”
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    The emergence of DNA in the RNA world: an in silico simulation study of genetic takeover
  2. 1922
    “…BACKGROUND: The revolutionary concept of “jumping genes” was conceived by McClintock in the late 1940s while studying the Activator/Dissociation (Ac/Ds) system in maize. …”
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    Active recombinant Tol2 transposase for gene transfer and gene discovery applications
  3. 1923
    “…However, recurrent therapeutic resistance presents revolutionary claims. Warburg effect and AKT signaling pathway was involved in the resistance to trastuzumab. …”
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    A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway
  4. 1924
    por Cerveau, Nicolas, Jackson, Daniel J.
    Publicado 2016
    “…BACKGROUND: Next-generation sequencing (NGS) technologies are arguably the most revolutionary technical development to join the list of tools available to molecular biologists since PCR. …”
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    Combining independent de novo assemblies optimizes the coding transcriptome for nonconventional model eukaryotic organisms
  5. 1925
    “…Alumina (Al(2)O(3)) is an ideal example; it has a higher fracture strength and thermal conductivity than today’s gain materials, which could lead to revolutionary laser performance. However, alumina has uniaxial optical proprieties, and the solubility of rare earths (REs) is two-to-three orders of magnitude lower than the dopant concentrations in typical RE-based gain media. …”
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    Gain in polycrystalline Nd-doped alumina: leveraging length scales to create a new class of high-energy, short pulse, tunable laser materials
  6. 1926
    “…Owing to the fundamental coupling of metabolism and tissue function, metabolic neuroimaging with hyperpolarised [1-(13)C]pyruvate has the potential to be revolutionary in numerous neurological disorders (e.g. brain tumour, ischemic stroke, and multiple sclerosis). …”
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    (13)C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI
  7. 1927
    “…BACKGROUND: The past decade has witnessed revolutionary advances in DNA sequencing, bioinformatics, and related technologies. …”
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    2298. Identifying and Addressing Implementation Barriers to Whole-Genome Sequencing (WGS) in State Public Health Laboratories
  8. 1928
    “…E-learning has been heralded as a revolutionary force for medical education, especially for low-resource countries still suffering from a dire lack of health care workers. …”
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    E-Learning for Medical Education in Sub-Saharan Africa and Low-Resource Settings: Viewpoint
  9. 1929
    “…The results outlined here demonstrate for the first time how effective multiplexed CRISPR-Cas9 gene disruption provides a framework for other researchers to utilize this revolutionary genome-editing tool effectively in R. toruloides.…”
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    Multiplexed CRISPR-Cas9-Based Genome Editing of Rhodosporidium toruloides
  10. 1930
    por AlOthman, Othman, Bobat, Suleiman
    Publicado 2020
    “…Ultimately, longer follow-up data must be presented before any definitive conclusions can be established for this potentially revolutionary technique. Presently, one can neither advocate nor refute EVAR over OSR.…”
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    Comparison of the Short and Long-Term Outcomes of Endovascular Repair and Open Surgical Repair in the Treatment of Unruptured Abdominal Aortic Aneurysms: Meta-Analysis and Systematic Review
  11. 1931
    “…Despite the advent of revolutionary methods of image analysis and high resolution three-dimensional imaging technology, basic conventional light microscopy still provides an incisive overview of the structure and tissue dynamics of the musculoskeletal system. …”
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    A novel RGB-trichrome staining method for routine histological analysis of musculoskeletal tissues
  12. 1932
    “…At present, wearable powered lower-limb exoskeletons are emerging as a revolutionary technology for robotic gait rehabilitation. …”
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    Systematic review on wearable lower-limb exoskeletons for gait training in neuromuscular impairments
  13. 1933
    “…BACKGROUND: The development of immune checkpoint inhibitors (ICIs) is a revolutionary milestone in the field of immune-oncology. …”
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    Robust Prediction of Immune Checkpoint Inhibition Therapy for Non-Small Cell Lung Cancer
  14. 1934
    “…BACKGROUND. Despite the revolutionary role of direct-acting antivirals for hepatitis C virus (HCV), the treatment timing for liver transplant candidates remains controversial. …”
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    Pretransplant Hepatitis C Virus Treatment Decreases Access to High-quality Livers
  15. 1935
    “…The last decade has witnessed revolutionary advances taken in immunotherapy for various malignant tumors. …”
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    Identification of CCL4 as an Immune-Related Prognostic Biomarker Associated With Tumor Proliferation and the Tumor Microenvironment in Clear Cell Renal Cell Carcinoma
  16. 1936
    por Choi, Hyung Woo, Shin, Dong-Wook, Yang, Jiajie, Lee, Sanghyo, Figueiredo, Cátia, Sinopoli, Stefano, Ullrich, Kay, Jovančić, Petar, Marrani, Alessio, Momentè, Roberto, Gomes, João, Branquinho, Rita, Emanuele, Umberto, Lee, Hanleem, Bang, Sang Yun, Jung, Sung-Min, Han, Soo Deok, Zhan, Shijie, Harden-Chaters, William, Suh, Yo-Han, Fan, Xiang-Bing, Lee, Tae Hoon, Chowdhury, Mohamed, Choi, Youngjin, Nicotera, Salvatore, Torchia, Andrea, Moncunill, Francesc Mañosa, Candel, Virginia Garcia, Durães, Nelson, Chang, Kiseok, Cho, Sunghee, Kim, Chul-Hong, Lucassen, Marcel, Nejim, Ahmed, Jiménez, David, Springer, Martijn, Lee, Young-Woo, Cha, SeungNam, Sohn, Jung Inn, Igreja, Rui, Song, Kyungmin, Barquinha, Pedro, Martins, Rodrigo, Amaratunga, Gehan A. J., Occhipinti, Luigi G., Chhowalla, Manish, Kim, Jong Min
    Publicado 2022
    “…Our systematic design and integration strategies are transformational and provide the foundation for realising highly functional smart lighting/display textiles over large area for revolutionary applications on smart homes and internet of things (IoT).…”
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    Smart textile lighting/display system with multifunctional fibre devices for large scale smart home and IoT applications
  17. 1937
    “…Deep learning’s automatic feature extraction has been a revolutionary addition to computational drug discovery, infusing both the capabilities of learning abstract features and discovering complex molecular patterns via learning from molecular data. …”
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    MolData, a molecular benchmark for disease and target based machine learning
  18. 1938
    “…Registration transparency has not been evaluated for clinical trials using these novel and revolutionary techniques in human participants. METHODS: Observational study of trials involving engineered site-specific nucleases and long-term follow-up observations, identified from the WHO ICTRP HGE Registry in November 2020 and two comprehensive reviews published in the same year. …”
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    Inadequate reporting quality of registered genome editing trials: an observational study
  19. 1939
    “…Introduction Radiation pneumonitis (RP) is a common dose-limiting toxicity of radiotherapy to the chest in lung cancer patients. Similarly, the revolutionary use of immune checkpoint inhibitors (ICIs) to treat lung cancer can be complicated by immune-related adverse events (irAEs), particularly checkpoint inhibitor pneumonitis (CIP). …”
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    Comparison of Pneumonitis Rates and Severity in Patients With Lung Cancer Treated by Immunotherapy, Radiotherapy, and Immunoradiotherapy
  20. 1940
    “…The therapeutic arsenal has been augmented by immune checkpoint inhibitors (ICIs), which nowadays represent the backbone of the second-line setting. Equally revolutionary was the FDA’s approval of erdafitinib, a potent fibroblast growth factor receptor (FGFR) inhibitor, the use of which is reserved for patients whose tumor harbors specific FGF pathway alterations. …”
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    Treatment Options for Metastatic Urothelial Carcinoma After First-Line Chemotherapy
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