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  1. 1961
    “…When introduced in the 1990s, immunization with DNA plasmids was considered potentially revolutionary for vaccine development, particularly for vaccines intended to induce protective CD8 T cell responses against multiple antigens. …”
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    Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA
  2. 1962
    “…RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by short interfering double-stranded RNA (siRNA) and has become a revolutionary tool for functional annotation of mammalian genes, as well as for development of novel therapeutics. …”
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    A Simplified and Versatile System for the Simultaneous Expression of Multiple siRNAs in Mammalian Cells Using Gibson DNA Assembly
  3. 1963
    “…Polytetrafluoroethylene-covered stents have emerged as a revolutionary strategy, enabling efficient endovascular repair of the entry port of such dissections, particularly the coronary ostia, and obviating the need for high-risk emergent surgical intervention. …”
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    Right coronary artery perforation extending to the coronary sinus of Valsalva during percutaneous intervention successfully sealed with polytetrafluoroethylene-covered stent: a case report
  4. 1964
    “…Successful use of this chronotherapeutic use of Dox and MLT in clinical trials increasing efficacy in preventing or suppressing breast cancer metastasis to bone while decreasing toxic side effects of doxorubicin would provide a revolutionary advancement in the treatment of bone metastatic breast cancer and decrease the morbidity and mortality associated with breast cancer metastasis to bone. …”
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    SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases
  5. 1965
    “…Genomic selection (GS) provides a revolutionary tool for the genetic improvement of farm animals. …”
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    Genomic mating as sustainable breeding for Chinese indigenous Ningxiang pigs
  6. 1966
    “…OBJECTIVE: MicroRNAs, as essential players in tumorigenesis, have been demonstrated to have a revolutionary effect on human cancer research. Ovarian cancer is the primary reason of death among gynecologic malignancies. …”
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    MicroRNA‐378a‐3p contributes to ovarian cancer progression through downregulating PDIA4
  7. 1967
    “…Currently, cancer immunotherapy has emerged as a revolutionary treatment for patients with advanced highly aggressive therapy-resistant tumors. …”
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    Prognostic and predictive value of FCER1G in glioma outcomes and response to immunotherapy
  8. 1968
    “…BACKGROUND: An increasing number of clinical trials require biomarker-driven patient stratification, especially for revolutionary immune checkpoint blockade therapy. Due to the complicated interaction between a tumor and its microenvironment, single biomarkers, such as PDL1 protein level, tumor mutational burden (TMB), single gene mutation and expression, are far from satisfactory for response prediction or patient stratification. …”
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    Dualmarker: a flexible toolset for exploratory analysis of combinatorial dual biomarkers for clinical efficacy
  9. 1969
    “…BACKGROUND: Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. …”
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    Dissecting immune cell stat regulation network reveals biomarkers to predict ICB therapy responders in melanoma
  10. 1970
    “…A liquid biopsy for brain tumour would prove revolutionary however in order to detect disease earlier the liquid biopsy needs to be able to detect smaller tumours; and current liquid biopsies perform worse when detecting smaller or earlier stage tumours. …”
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    Rapid Spectroscopic Liquid Biopsy for the Universal Detection of Brain Tumours
  11. 1971
    “…Enabling VIGS under native conditions in the field according to applicable safety regulations could be a revolutionary advance for ecological research. RESULTS: Here, we report the development of an enhanced thermal tolerant VIGS vector system based on a TRV California isolate. cDNA clones representing the whole viral genome were sequenced and used to construct separate binary plant transformation vectors for functional elements of RNA1 (6765 nt) and RNA2 (3682 nt). …”
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    California TRV-based VIGS vectors mediate gene silencing at elevated temperatures but with greater growth stunting
  12. 1972
    “…Metagenomics next-generation sequencing (mNGS) is a revolutionary and highly sensitive method that may help in diagnosing atypical cases, even when trace amounts of pathogens are present. …”
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    mNGS helped diagnose scrub typhus presenting as a urinary tract infection with high D-dimer levels: a case report
  13. 1973
    “…ABSTRACT: The introduction of robotics in living donor liver transplantation has been revolutionary. We aimed to examine the safety of robotic living donor right hepatectomy (RLDRH) compared to open (ODRH) and laparoscopic (LADRH) approaches. …”
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    Robotic Living Donor Right Hepatectomy: A Systematic Review and Meta-Analysis
  14. 1974
    “…Purpose: Combined radiotherapy (RT) and immune checkpoint-inhibitor (ICI) therapy can act synergistically to enhance tumor response beyond what either treatment can achieve alone. Alongside the revolutionary impact of ICIs on cancer therapy, life-threatening potential side effects, such as checkpoint-inhibitor-induced (CIP) pneumonitis, remain underreported and unpredictable. …”
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    Lung Inflammation Predictors in Combined Immune Checkpoint-Inhibitor and Radiation Therapy—Proof-of-Concept Animal Study
  15. 1975
    “…Background Growth factors from platelets have been emerging as a revolutionary treatment with the ability to induce cell growth in the skin, which results in retarding and reversing the aging process. …”
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    A Prospective Multicenter Study to Evaluate the Safety and Efficacy of the Topical Application of MYOWNN™, an Autologous Growth Factor Concentrate (AGFC) Serum, in Anti-Aging
  16. 1976
    “…INTRODUCTION: Chimeric antigen receptor (CAR) T-cells represent a revolutionary class of immunotherapy, achieving considerable success in hematological cancers but generally failing to control solid tumors, including gliomas, partly due to the lack of a ubiquitously-expressed target antigen. …”
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    SYST-12 D2C7 CAR: A NOVEL CAR T CELL THAT SIMULTANEOUSLY TARGETS WILDTYPE EGFR AND ITS MUTANT ISOFORM EGFRVIII FOR TREATMENT OF GLIOMA AND BRAIN METASTASES
  17. 1977
    “…Immunotherapy based on immune checkpoint inhibitors (ICIs) is a revolutionary tool in oncology. This study was stimulated by our recent experience with a metastatic Pit1-derived PitNET expressing PDL1 and showing a remarkable response to pembrolizumab. …”
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    Immunotherapy for Aggressive and Metastatic Pituitary Neuroendocrine Tumors (PitNETs): State-of-the Art
  18. 1978
    “…BACKGROUND: Early studies have demonstrated the potential of deep learning in bringing revolutionary changes in medical analysis. However, it is unknown which deep learning based diagnostic pattern is more effective for differentiating malignant and benign breast lesions (BLs) and can assist radiologists to reduce unnecessary biopsies. …”
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    A deep learning-based diagnostic pattern for ultrasound breast imaging: can it reduce unnecessary biopsy?
  19. 1979
    por Knight, Alan
    Publicado 2021
    “…From a long term perspective, examines how, contrary to popular belief, the country is now less violent than during the revolutionary process.The comparison function has been violence in the country's different historical cycles allows differentiation of political violence with respect to criminal and interpersonal violence.Indeed, the analysis of political violence in their macro and micro dimensions, during the twentieth century, lets see how the cycles of violence have varied according to the institutional capacities of the political regime to institutionalize conflict resolution without such decision represents a full state monopoly of legitimate physical violence.Keywords: Political Violence, Murder, Mortality, Revolution RésuméCet article décrit les différents types de violence que le Mexique a connu au siècle dernier. …”
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    Guerra, violencia y homicidio en el México moderno
  20. 1980
    “…BACKGROUND: Chimeric antigen receptor (CAR)-T cell-based immunotherapy constitutes a revolutionary advance for treatment of relapsed/refractory hematological malignancies. …”
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    Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis
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