“…In addition, miR199-a/b-5p post-transcriptionally suppressed Rho-associated coiled-coil kinase 1 (ROCK1). This in turn led to inhibition of ROCK1/MLC and PI3K/Akt signaling, which is necessary for HCC proliferation and metastasis. …”
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“…Endothelial dysfunction is one of the main pathological changes in Obstructive sleep apnoea (OSA). The Rho kinase (ROCK) pathway is associated with endothelial dysfunction. …”
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“…This data article describes the soils characterisation, bedrock geochemical composition and descriptive statistics of (87)Sr/(86)Sr in wines, grape saps, labile fractions of soils (bio-available), whole soils, and bedrocks used to explore the Sr isotope conservation from rocks and soils to vine and wine. These data also describe the reproducibility of the isotopic composition of wine over four harvest years (2008–2011) on 11 selected experimental parcels (sampling point). …”
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“…BACKGROUND: Students following a low education track have an increased risk for developing problem behaviors. Rock and Water is a widespread, but still poorly evaluated, intervention that aims to improve students’ socio-emotional adjustment and social safety. …”
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“…Results showed that (1) the topographic aspect significantly affected the vegetation restoration and artificial soil quality of rock-cut slopes restored by ESSS; (2) the ecological restoration effect of north-facing slopes were better than that of south-facing slopes; and (3) the vegetation and soil conditions of natural slopes were better than those of rock-cut slopes. …”
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“…CONCLUSION: Irrespective of TGF-β1 activation status, fasudil suppressed actin polymerization and collagen synthesis and induced apoptosis in human urethral scar fibroblasts via the Rho/ROCK signaling pathway.…”
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“…Subaerial biofilms (SAB) are an important factor in weathering, biofouling, and biodeterioration of bare rocks, building materials, and solar panel surfaces. …”
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“…We report here on soft-template electropolymerizations of polypyrrole (Ppy)-based nanocomposites triggered by graphene platelets (GP) from shungite (SH) rocks. A properly designed procedure for an efficient extraction of graphene platelets from SH powders is established to produce remarkable graphene materials in a low oxidation state and with a high electrical conductivity (1490 S cm(−1)). …”
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“…These processes of dissolution and entrapment can result in the formation of rock coatings that contain elevated levels of heavy metals. …”
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“…This study aimed to evaluate the effects of ROCK/PTEN/PI3K on ZJW-induced apoptosis in vitro and in vivo. …”
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“…DISCUSSION: Sex, Bugs, and Rock ’n’ Roll is a promising initiative for improving medical student knowledge and comfort with sexual health. …”
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“…Furthermore, inhibiting S1PR2 resulted in the deceased expression of RhoA, ROCK1, and Drp1 while inhibiting ROCK1 led to the downregulated expression of Drp1. …”
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“…Consistently, inhibition of either MLCK or ROCK enhanced the KLF4 expression. Moreover, we observed that ROCK/MLCK up‐regulated miR‐92a expression in VSMCs through signal transducer and activator of transcription 3 (STAT3) activation. …”
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“…In this study we explored whether activation of the Rho kinase/ROCK/p38 MAPK pathway is responsible for LPI‐induced extension of I/R injury. …”
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“…The data presented in this article are related to the research article entitled “Multivariate analysis of trace elements leaching from coal and host rock” [1]. During coal mining, coal and host rock undergo water-rock interaction, leading to release of trace elements to surface and ground water. …”
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“…AFM13 is the most advanced candidate from our fit-for-purpose redirected optimized cell killing (ROCK®) antibody platform, which comprises a plethora of CD16A-binding innate immune cell engagers with unique properties. …”
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“…Due to the high sequence similarity of GRK2 with the A, G, and C family (AGC family) of kinases, the inhibition of GRK2 also leads to the inhibition of AGC kinases such as Rho-associated coiled-coil kinase 1 (ROCK1). Therefore, unraveling the mechanisms to selectively inhibit GRK2 poses an important challenge. …”
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“…In addition, SP induces the pro-fibrotic changes through activation of the RhoA/ROCK pathway. Taken together, we show that SP has a pro-fibrotic effect in both quiescent human keratocytes and during the onset of fibrosis in an in vitro human corneal fibrosis model. …”
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