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  1. 2681
  2. 2682
    “…Mechanistic study indicated that perturbation of the ROCK1/PTEN/PI3K/Akt signalling pathway plays a vital role in the arctiin‐mediated anti‐proliferative effect. …”
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  3. 2683
    “…Prior incubation with statins downregulated the TGF-β2-induced phosphorylation of MYPT1 and MLC, which are downstream substrates of RhoA and ROCKs. CONCLUSIONS: Statins inhibited the TGF-β2-mediated regulation of MMP-2 and MMP-9 by inhibiting the RhoA/ROCK signaling pathway. …”
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  4. 2684
  5. 2685
    “…In the present study, we explored the antifibrotic effects of simvastatin and ROCK inhibitor Y-27632 in primary cultured GO orbital fibroblasts and tried to explain the molecular mechanisms behind these effects. …”
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  6. 2686
    “…Immunoblot analysis revealed a lower expression of eNOS, sGC, and PKG, while there was a higher expression of RhoA-dependent kinase 2 (ROCK2) in the PA from PAH-MCT than in the control. …”
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  7. 2687
    “…Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a mouse model of AD. miR-135a-5p levels are significantly reduced in excitatory hippocampal neurons of AD model mice. …”
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  8. 2688
  9. 2689
    “…The datasets served as the basis for interpretation of melt crystallization for lamprophyric and carbonatitic dykes in the crust, to supplement many papers devoted to mantle sources and melting parameters of these rocks based on radiogenic isotopes and trace elements. …”
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  10. 2690
  11. 2691
    “…LPA increased Rho-associated protein kinase 2 (ROCK2) expression and PI3K/AKT activation; moreover, the pharmacological inhibition of ROCK2 and PI3K/AKT signaling suppressed LPA-induced cell cycle progression. …”
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  12. 2692
    “…Conclusions: Gα(12) overexpression by ER stress facilitates hepatocyte ferroptosis through ROCK1-mediated dysregulation of ALOX12, and miR-15a, supporting the concept that inhibition of Gα(12) overexpression and/or ROCK1 axis may constitute a promising strategy for acute liver injury.…”
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  13. 2693
    “…Nickel doped rock salt structured CoO, Ni(x)Co(1−x)O (0 ≤ x ≤ 0.5), were synthesized by employing a solid state metathesis synthesis route. …”
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  14. 2694
  15. 2695
    “…Metasedimentary and meta‐mafic samples collected from 104 m of core reveal that the LT sole subducted to similar peak P as HT rocks preserved elsewhere in Oman, but experienced ∼300°C lower peak T. …”
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  16. 2696
  17. 2697
    “…In addition, miR-451b overexpression decreased the expression of RhoA, ROCK2, COL1A1, and COL2A1 in lung fibroblasts. CONCLUSIONS: Our data suggest that p300/miR-451b protects against CSE-induced cell stress possibly through downregulating RhoA/ROCK2 pathway.…”
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  18. 2698
    “…The present study examines the prehistoric human skeletal remains retrieved starting from the 1920s in the deposit of the Farneto rock shelter, situated in the area of the ‘Parco dei Gessi Bolognesi e Calanchi dell’Abbadessa’ (San Lazzaro di Savena, Bologna, northern Italy). …”
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  19. 2699
  20. 2700
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