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  1. 3901
    “…Here, we show that ROCKs are expressed in medulloblastoma, with higher ROCK2 mRNA expression in metastatic compared to non-metastatic tumors. …”
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    Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth
  2. 3902
    “…However, the role of ROCK in flow-induced vascular remodeling has not been fully defined. …”
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    Fasudil, a Rho-kinase inhibitor, prevents intima-media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow-induced vascular remodeling
  3. 3903
    “…The improved split Hopkinson pressure bar (SHPB) was used to study the dynamic mechanical properties and failure characteristics of surrounding rock in deep rock mass engineering that is under high stress and affected by blasting excavation and other dynamic disturbances. …”
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    Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance
  4. 3904
    por Shi, Jianjian, Wei, Lei
    Publicado 2022
    “…The ROCK family contains two members, ROCK1 and ROCK2, which share 65% overall identity and 92% identity in kinase domain. …”
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    Rho Kinases in Embryonic Development and Stem Cell Research
  5. 3905
    “…BACKGROUND: The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. …”
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    Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2
  6. 3906
    “…Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. …”
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    Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin
  7. 3907
    “…In the surrounding rock, the main bearing stratum is the plastic reshaping and flowing area. …”
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    Experimental research on the structural instability mechanism and the effect of multi-echelon support of deep roadways in a kilometre-deep well
  8. 3908
    “…The rheological phenomenon of rock mass affects the long-term safety of rock mass engineering. …”
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    Study on Shear Creep Characteristics of the Discontinuities with Different 3D Morphologies
  9. 3909
    “…The results show expression of both the ROCK1 and ROCK2 isoforms in lymphatic vessels. Inhibition of ROCK increased lymphatic end diastolic diameter and end systolic diameter in a concentration-dependent manner. …”
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    Rho Kinase Enhances Contractions of Rat Mesenteric Collecting Lymphatics
  10. 3910
    “…PURPOSE: We evaluated prevention of transforming growth factor β (TGFβ)–induced transdifferentiation of cultured scleral fibroblasts to myofibroblasts by rho-associated protein kinase (ROCK) inhibitors. Additionally, we tested whether local delivery of ROCK inhibitors reduced scleral fibroblast proliferation in response to chronic intraocular pressure (IOP) elevation. …”
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    Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma
  11. 3911
    “…In order to analyze the relation between rock-breaking energy consumption and bit crown shape quantificationally, the paper puts forward an idea to take “per revolution-specific rock-breaking work” as objective function, and analyzes the relationship between rock properties, inner cone angle, outer cone arc radius, and per revolution-specific rock-breaking work by means of explicit dynamic finite element method. …”
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    Numerical simulation study on the optimization design of the crown shape of PDC drill bit
  12. 3912
    “…Rock coasts are perceived to be stable, however, recent occurrence of stacks of rocks and subsequent loss of some rocky coasts poses a challenge for research. …”
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    Lithological effects on rocky coastline stability
  13. 3913
    “…Rho-associated coiled-coil kinase (ROCK) signaling can affect glaucoma risk by regulating trabecular meshwork outflow. …”
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    Genetic Risk and Phenotype Correlation of Primary Open-Angle Glaucoma Based on Rho-Kinase Gene Polymorphisms
  14. 3914
    “…Considering the recent developments of deep mining, investigating the rock properties under high ground stress periodic load is highly demanded. …”
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    Analysis of fracture deformation field and energy evolution of granite after high confining pressure cyclic load pre-damage
  15. 3915
    “…This rock underwent unpredictable large and time-dependent deformation during excavation. …”
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    Unified transient creep constitutive model based on the crack evolution of micritic bioclastic limestone
  16. 3916
    “…The destructive behavior of rocks and the evolution behavior of cracks are highly correlated. …”
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    Study on the infrared dynamic evolution characteristics of different joint inclination phyllite under uniaxial compression
  17. 3917
    “…In soft rock tunnels, there are often large deformations during construction, especially when the groundwater seepage and softens the surrounding rock. …”
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    Investigation of internal damage evolution in gneiss considering water softening
  18. 3918
    por Xue, Yi, Cao, Zhengzheng, Shen, Wenlong
    Publicado 2019
    “…Results indicate that the rock burst triggered by the instability is a destabilization phenomenon. …”
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    Destabilization and energy characteristics of coal pillar in roadway driving along gob based on rockburst risk assessment
  19. 3919
    por Chen, Haozhe, Shao, Zhushan, Zhang, Zhe
    Publicado 2022
    “…The investigations are principally at the angle of time and space, which refers to the creep property and damaged scope for surrounding rock. For the theoretical method, the analytical elastic and elastoplastic models for deep tunnel cross section and the creep model for brittle rock material from a microscopic view were combined. …”
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    Impact of Brittle Creep Failure on Time-Delayed Characteristics of Rockburst
  20. 3920
    “…Long-term exposure to ROCK inhibitor led to an increase in cell division throughout the culture in both lines. …”
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    Effect of Rho–Associated Kinase Inhibitor on Growth Behaviors of Human Induced Pluripotent Stem Cells in Suspension Culture
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