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  1. 3981
    “…The Rho-associated coiled-coil kinase (ROCK) inhibitor Y-27632 inhibits senescence induced but not activation induced phosphatidylserine exposure. …”
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    Rho Associated Coiled-Coil Kinase-1 Regulates Collagen-Induced Phosphatidylserine Exposure in Platelets
  2. 3982
    “…Due to the wide spectrum of biological processes regulated by ROCK, many additional clinical indications might also benefit from ROCK inhibition. …”
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    Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors
  3. 3983
    “…In IDCs co-expressing RhoA and ROCK, F-actin expression was stronger on the tumor interface, particularly at the edges of tumor cells, than it was in ROCK-negative IDCs (P<0.0001). …”
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    Roles of Ras Homolog A in Invasive Ductal Breast Carcinoma
  4. 3984
    “…It has been previously reported that Rho-kinase (ROCK) and poly ADP-ribose polymerase (PARP) serve critical roles in myocardial ischemia/reperfusion (I/R) injury. …”
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    Rho-kinase signaling pathway promotes the expression of PARP to accelerate cardiomyocyte apoptosis in ischemia/reperfusion
  5. 3985
    “…RhoA/Rho-associated protein kinase (ROCK) signaling is a recognized mediator of its pathogenesis, largely through mediating the profibrotic response. …”
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    Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease
  6. 3986
    “…Clay is one of the important base materials in slope restoration. The adhesion of clay–rock interface plays a decisive role in the repairing effect on rock slopes. …”
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    Experimental Study on Interfacial Friction Characteristics of Reinforced Clay
  7. 3987
    “…This study focuses on how the Diethylenetriaminepentaacetic acid (DTPA) chelating agent performs in modifying rock surface charge. The impact of concentration, brine salinity, potential determining ions (PDIs), oil presence, Fe(3+) ions, and solution pH on the effectiveness of DTPA in altering rock surface charge was evaluated. …”
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    A comprehensive evaluation of the effect of key parameters on the performance of DTPA chelating agent in modifying sandstone surface charge
  8. 3988
    “…At six oil production platform locations in the Gulf of Mexico, rock hind social group size and typical male rock hind social behavior were documented. …”
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    Behavior, Color Change and Time for Sexual Inversion in the Protogynous Grouper (Epinephelus adscensionis)
  9. 3989
    “…PDBu-induced contraction in bladder smooth muscle involved both activation of PKC and PKC-dependent activation of ROCK. CPI-17 as a major downstream effector, is phosphorylated by PKC and ROCK during PDBu and DOG stimulation. …”
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    Phorbol 12,13-Dibutyrate-Induced, Protein Kinase C-Mediated Contraction of Rabbit Bladder Smooth Muscle
  10. 3990
    “…The mRNA level of RhoA, RhoC, ROCK1 and ROCK2 were elevated in aneurismal aorta. …”
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    Inhibition of Rho-Kinase by Fasudil Suppresses Formation and Progression of Experimental Abdominal Aortic Aneurysms
  11. 3991
    “…These results indicate that TFR has a protective effect on rat cardiomyocytes A/R damage, and the protective mechanism may be engaged with the inhibition of ROCK(1) and ROCK(2) and activation of K(+) channels.…”
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    Protective Effect and Mechanism of Total Flavones from Rhododendron simsii Planch Flower on Cultured Rat Cardiomyocytes with Anoxia and Reoxygenation
  12. 3992
    “…The activation of RhoA/ROCK in cancer cells activates MLC and increases migration, while the genetic-down-regulation of RhoA and pharmacological inhibition of ROCK reduced cell scattering and invasion. …”
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    The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion via IGF-1 and PAI-1
  13. 3993
    “…The spatial variability of stony desertification at small scales is influenced by many factors, and the variability at medium scales is jointly influenced by gradient, rock content, and rock exposure. At large scales, the spatial variability of stony desertification is mainly influenced by soil thickness and rock content.…”
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    Spatial Distribution of Stony Desertification and Key Influencing Factors on Different Sampling Scales in Small Karst Watersheds
  14. 3994
    “…In addition, RhoA, ROCK1, and ROCK2 expression levels were increased upon BCNI-ED induction, and HJI successfully inhibited cavernosum fibrosis and the activation of RhoA/ROCK2 signaling. …”
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    Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury
  15. 3995
    “…The rheology of cement grouts often plays a crucial role in the success of rock grouting. In practice, the rheological parameters should be timely adjusted according to the evolution of grouting pressure, flow rate and injection time. …”
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    Estimation of Viscosity and Yield Stress of Cement Grouts at True Ground Temperatures Based on the Flow Spread Test
  16. 3996
    “…The small GTPase RhoA and its effector Rho-associated protein kinase (ROCK) are critical to several cellular functions, including cytoskeleton reorganization, cell survival, and cell differentiation. …”
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    0.5-Gy X-ray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts
  17. 3997
    “…SF formation takes center stage in phenotype control, as both SF formation and SOX9 phosphorylation for COL2 expression are ROCK activity-dependent. Explaining how it is molecularly possible that dedifferentiation induces low COL2 expression but high SF formation, this review theorized that, in chondrocyte SOX9, phosphorylation by ROCK might effectively be sidelined in favor of other SF-promoting ROCK substrates, based on a differential ROCK affinity. …”
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    Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function
  18. 3998
    “…Deep high-stress roadway excavation under unloading disturbance inevitably leads to damage deterioration of the surrounding rock, which poses a serious threat to its stability. …”
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    Evaluation of white sandstone mechanical behaviour and the energy evolution of prepeak unloading damage
  19. 3999
    “…Deformation and failure of the roadway surrounding rock under dynamic disturbance were explored, which is essential for the control of the surrounding rock. …”
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    Numerical simulation of roadway deformation and failure under different degrees of dynamic disturbance
  20. 4000
    por Martin, Kathy
    Publicado 2012
    “…Rock ptarmigan have a slower life history strategy than white-tailed ptarmigan in the study region with lower annual reproductive effort but higher adult survival. …”
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    Influence of life history strategies on sensitivity, population growth and response to climate for sympatric alpine birds
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