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4101por Liao, Huo-cheng, Zhong, Si-gan, Li, Peng, Chen, Wei-bin, Cheng, Cheng, Wang, Yue-gang, Wu, Ping-sheng, Xiao, Chun“…Compared to baseline, leukocyte ROCK2 activity and daily average exercise time were improved in both groups. …”
Publicado 2015
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4102por Li, Xuying, Zhai, Qian, Gou, Xingchun, Quan, Minxue, Li, Yansong, Zhang, Xiaohua, Deng, Bin, Tian, Yi, Wang, Qiang, Hou, Lichao“…PirB knockdown alleviated synaptic deficits and cognitive impairment after CSR by inhibiting the RhoA/ROCK2/LIMK1/cofilin signalling pathway. Moreover, we found that fasudil, a widely used ROCK2 inhibitor, could mimic the beneficial effect of PirB knockdown and ameliorate synaptic deficits and cognitive impairment, further demonstrating that PirB induced cognitive dysfunction after CSR via the RhoA/ROCK2/LIMK1/cofilin signalling pathway. …”
Publicado 2022
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4103“…Rocks present complex deformation behaviours and damage processes under triaxial cyclic loading—a subject not yet sufficiently researched. …”
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4104“…Deformation twinning was thought as impossible in ionic compounds with rock-salt structure due to the charge effect on {111} planes. …”
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4105por Zhang, Zhiqun, Ottens, Andrew K., Larner, Stephen F., Kobeissy, Firas H., Williams, Melissa L., Hayes, Ronald L., Wang, Kevin K. W.“…Robust neurite outgrowth (NOG) was induced by ROCK inhibitors Y-27632 and H-1152 in a time-and dose-dependent manner. …”
Publicado 2006
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4106por Alakbari, Fahd Saeed, Mohyaldinn, Mysara Eissa, Muhsan, Ali Samer, Hasan, Nurul, Ganat, Tarek“…Based on this review, the nanoparticle-related martials are highly recommended to be applied as sand consolidation agents, due to their ability to generate acceptable rock strength with insignificant reduction in rock permeability.…”
Publicado 2020
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4107“…Rocks that react with liquid water are widespread but spatiotemporally limited throughout the solar system, except for Earth. …”
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4108“…The numerical simulations indicate that the simplification of the fluid-deteriorated formation into an isotropic rock results in an underestimation of the proppant embedment depth, and this deviation increases with the scale contrast between rock specimens and proppants. …”
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4109“…In underground engineering, reinforcement is a necessary means to ensure the stability of surrounding rock. Due to the stress redistribution caused by excavation disturbances, the reinforced rock mass is frequently subjected to loading and unloading, and its mechanical properties change accordingly. …”
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4110por Yao, Lin, Romero, Maritza J., Toque, Haroldo A., Yang, Guang, Caldwell, Ruth B, Caldwell, R. William“…Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. …”
Publicado 2010
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4111“…After the first break, the broken rock above it will settle synchronously until the rock blocks form a hinged structure and then collapse. …”
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4112por Yang, Liyun, Gong, Shiqi, Qiao, Peipei, Zhao, Runyu, Huang, Shuixian, Zhou, Jieyu, Hu, An“…CONCLUSIONS: CAFs-derived ROCK1 via JAK2/STAT3/ERK1/2 axis mediated EMT to promote LSCC metastasis and targeting ROCK1 might provide a potential treatment strategy for LSCC. …”
Publicado 2023
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4113“…It researches the space–time continuous sensing of rock–soil mass above the coal seam based on Distributed Fiber Optic Sensing (DFOS). …”
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4114por Unbekandt, Mathieu, Croft, Daniel R, Crighton, Diane, Mezna, Mokdad, McArthur, Duncan, McConnell, Patricia, Schüttelkopf, Alexander W, Belshaw, Simone, Pannifer, Andrew, Sime, Mairi, Bower, Justin, Drysdale, Martin, Olson, Michael F“…Along with the related ROCK1 and ROCK2 kinases, the MRCK proteins initiate signalling events that lead to contractile force generation which powers cancer cell motility and invasion. …”
Publicado 2014
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4115por Stam, Kelly, Cai, Zongye, van der Velde, Nikki, van Duin, Richard, Lam, Esther, van der Velden, Jolanda, Hirsch, Alexander, Duncker, Dirk J, Merkus, Daphne“…Since ROCK2 has been shown to be involved in hypertrophy, oxidative stress, fibrosis and endothelial dysfunction, ROCK2 inhibition may present a viable therapeutic target in CTEPH. …”
Publicado 2019
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4116por Ren, Zhouzheng, Sun, Wenqiang, Cheng, Xi, Liu, Yanli, Han, Di, Yan, Jiakun, Pan, Chong, Duan, Yulan, Yang, Xiaojun“…A corn-soybean meal–based diet, with no inorganic phosphate rock, was formulated to contain 0.12% nonphytate phosphorus (nPP), 3.8% calcium, and 2,000 FTU/kg phytase. …”
Publicado 2020
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4117“…The results of RT-PCR showed that SOD1 and SOD2 mRNA in the H(2)O(2) group was significantly reduced, and the contents of GPX1 and GPX3 in the H(2)O(2) group were significantly decreased by enzyme-linked immunosorbent assay (ELISA). The expression of ROCK1, ROCK2, and downstream phosphorylation of myosin phosphatase target subunit-1 (p-MYPT-1) was significantly increased in the H(2)O(2) group, while fasudil inhibited the increase of ROCK1, ROCK2, and p-MYPT-1. …”
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4118“…The current understanding on the clinical efficacy of Rho-associated protein kinase (ROCK) inhibitor for treating Fuchs endothelial corneal dystrophy is summarized to clarify whether the “off-label” ROCK-inhibitor eye-drop application are appropriate. …”
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4119“…Re-use of excavated rock and soil from subsurface tunnelling has become an essential legal and technical factor in underground construction projects. …”
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4120“…This role for p120 was traced to its activity in suppression of the RhoA–ROCK pathway, which appears to be essential for AIG. …”
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