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4121“…JNK knockdown or ROCK inhibitor treatment has no effect on activation of Rho by G12. …”
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4122por Delogu, Mauro, Ghetti, Giulia, Gugiatti, Alessandro, Cotti, Claudia, Piredda, Isabella, Frasnelli, Matteo, De Marco, Maria A.“…Cloacal swabs were collected from 11 rock partridges and from 68 tetraonids including 23 alpine rock ptarmigans and 45 black grouses. …”
Publicado 2013
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4123por Lechner, Rainer T., Fritz-Popovski, Gerhard, Yarema, Maksym, Heiss, Wolfgang, Hoell, Armin, Schülli, Tobias U., Primetzhofer, Daniel, Eibelhuber, Martin, Paris, Oskar“…[Image: see text] We reveal the existence of two different crystalline phases, i.e., the metastable rock salt and the equilibrium zinc blende phase within the CdS-shell of PbS/CdS core/shell nanocrystals formed by cationic exchange. …”
Publicado 2014
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4124“…ROCK inhibition was also able to attenuate the pillar-induced decrease in β-actin. …”
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4125“…Specifically, most of the landslides were shallow landslides, rockfalls and rock avalanches and were small in scale. The failure modes of landslides mainly include wedge rock mass failure, residual deposit failure, relaxed rock mass failure and weathered rock mass failure. …”
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4126“…It has been demonstrated that actomyosin rearrangement during macrophage differentiation is dependent on Rho-associated protein kinase (ROCK). Myosin phosphatase (MP) target subunit-1 (MYPT1) is one of the major cellular substrates of ROCK, and MP is often a counter enzyme of ROCK; therefore, MP may also control macrophage differentiation. …”
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4127por Mateos-Olivares, Milagros, García-Onrubia, Luis, Valentín-Bravo, Fco. Javier, González-Sarmiento, Rogelio, Lopez-Galvez, Maribel, Pastor, J. Carlos, Usategui-Martín, Ricardo, Pastor-Idoate, Salvador“…This is why the Rho/ROCK signalling pathway has been proposed as a possible target for new treatments. …”
Publicado 2021
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4128“…The oxygen vacancies within the perovskite slabs have very low formation energies, but demonstrate high energy barriers for migration and low hydration properties; while in the case of those in the rock salt layers, it’s contrary. Interestingly, protons have similar migration abilities in the perovskite slabs and rock salt layers. …”
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4129por Liu, Handong, Liu, Shuai, Zhao, Yawen, Wang, Jialiang, Zheng, Chao, Xia, Zhiguo, Zheng, Guang“…To better understand the effect of the size of hole defects on the mechanical properties of a rock mass, the two-dimensional particle flow discrete element code (PFC2D) is applied to establish rock mass models with single circular hole defects of different diameters. …”
Publicado 2022
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4130por Akintola, George Oluwole, Amponsah-Dacosta, Francis, Rupprecht, Steven, Mhlongo, Sphiwe Emmanuel“…The total organic carbon (TOC) contents averaging at 47 wt%, indicating an excellent source rock. The Rock-Eval 6 programmed pyrolysis samples showed S2 value (15.25–16.47 mg HC/g rock) with an average of 15.69 mg HC/g rock and Hydrogen index (HI) (34.0–37.0 mg HC/g TOC) indicating a Type-III Kerogen dominance prone to gas generation. …”
Publicado 2023
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4131“…Mastering the creep deformation characteristics of rock under different temperature conditions is of great significance for studying the long-term stability and deformation mechanism of geotechnical engineering. …”
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4132por Liu, Houbin, Cui, Shuai, Meng, Yingfeng, Fan, Yu, Liu, Teng, Yu, Anran, Hu, Zhongzhi“…The results show that the parabolic curve derived from the uniaxial rock mechanics test data of the XuJiahe formation is not suitable for the triaxial test results under high confining pressure. …”
Publicado 2019
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4133por Samarkin, Yevgeniy, Amao, Abduljamiu Olalekan, Aljawad, Murtada Saleh, Borji, Mostafa, Scott, Norman, AlTammar, Murtadha J., Alruwaili, Khalid M.“…Estimating the rocks’ elastic modulus and compressive strength is essential to comprehend the rock matrix’s mechanical response during drilling and production operations. …”
Publicado 2023
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4134por Williams, L J, Mukherjee, D, Fisher, M, Reyes-Aldasoro, C C, Akerman, S, Kanthou, C, Tozer, G M“…We tested the hypothesis that activation of Rho/Rho kinase (ROCK) is fundamental to the effects of this drug in vivo. …”
Publicado 2014
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4135por Wróbel, Andrzej, Doboszewska, Urszula, Rechberger, Ewa, Rojek, Karol, Serefko, Anna, Poleszak, Ewa, Skalicka-Woźniak, Krystyna, Dudka, Jarosław, Wlaź, Piotr“…Studies have indicated that Rho kinase (ROCK) inhibitors may suppress detrusor overactivity symptoms and possess anti-inflammatory properties. …”
Publicado 2017
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4136por Li, Xue-Bo, Ding, Ming-Xia, Ding, Chun-Li, Li, Liang-Liang, Feng, Jinzhou, Yu, Xiao-Jun“…Y-27632 decreased the expression of ROCK-II and phosphorylated (p)-CRMP2, and suppressed the increased ROCK-II and p-CRMP2 induced by LPS; however, no effect on the levels of TLR4 expression was observed. …”
Publicado 2018
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4137“…Protein and mRNA expressions of ET(A)Rs and ET(B)Rs, along with ROCK1 and ROCK2 isoforms, were detected in retinal venules. …”
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4138por Ezzat, Shahira M., Okba, Mona M., Ezzat, Marwa I., Aborehab, Nora M., Mohamed, Shanaz O.“…The aim of the study was to screen E. longifolia aqueous extract (AE) and isolates for ROCK-II inhibition. Results. The AE (1-10 μg/ml) showed a significant inhibition for ROCK-II activity (62.8-81%) at P < 0.001 with an IC(50) (651.1 ± 32.9 ng/ml) compared to Y-27632 ([(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride]) (68.15-89.9 %) at same concentrations with an IC(50) (192 ± 8.37 ng/ml). …”
Publicado 2019
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4139“…Ultramafic rocks undergo successive stages of hydration and oxidation during water/rock interaction, giving rise to secondary minerals such as brucite, serpentine, magnetite and the production of H(2(g)). …”
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4140“…CONCLUSIONS: In a mouse model of NAFLD, RKI-1447 inhibited ROCK and modulated insulin resistance, oxidative stress, and inflammation through the ROCK/TLR4/TBK1/IRF3 pathway.…”
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