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4181por Singh, Jagmohan, Mohanty, Ipsita, Addya, Sankar, Phillips, Benjamin, Mee Yong, Hwan, An, Steven S., Penn, Raymond B., Rattan, Satish“…These findings suggest miRNA-139-5p is capable of significantly influencing the phenotypic tonicity in smooth muscle via ROCK2: a lack of tone in ASM may be associated with the suppression of ROCK2 by high expression of miRNA-139-5p, whereas basal IAS tone may be associated with the persistence of ROCK2 due to low expression of miRNA-139-5p.…”
Publicado 2017
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4182por Wilson, Jamie L., Warburton, Rod, Taylor, Linda, Toksoz, Deniz, Hill, Nicholas, Polgar, Peter“…While the regulation of ET-1 induced cell contraction was found to be similar in PAH and non-PAH cells, a key difference was the response to pharmacological inhibitors and to siRNA knockdown of Rho kinases (ROCK1/ROCK2). The PAH cells required much higher concentrations of inhibitors to abrogate ET-1 induced contractions and their contraction was not affected by siRNA against either ROCK1 or ROCK2. …”
Publicado 2018
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4183por Holmes, Toby, Brown, Andrew W., Suggitt, Marie, Shaw, Lucy A., Simpson, Lucy, Harrity, Joseph P. A., Tozer, Gillian M., Kanthou, Chryso“…CA4P activates the actin-regulating RhoA-GTPase/ ROCK pathway, which is required for full vascular disruption. …”
Publicado 2020
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4184por Nolte, Tanja, Jansen, Simon, Halle, Ingrid, Scholz, Armin Manfred, Simianer, Henner, Sharifi, Ahmad Reza, Weigend, Steffen“…Regarding crossbreds, the Bresse Gauloise × White Rock cross performed best (peak production 98.1%, mean egg weight 58.0 g). …”
Publicado 2020
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4185“…The protein levels of TJ and the Rho/ROCK signaling pathway were also measured. The results showed that in the SCI group, intestinal mucosal injury score, intestinal permeability, and levels of Rho and ROCK1 were higher, and TJ proteins occludin and ZO-1 were lower than those in the SH group (P < 0.01). …”
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4186por Ma, Liyuan, Huang, Xinping, Wang, Hongmei, Yun, Yuan, Cheng, Xiaoyu, Liu, Deng, Lu, Xiaolu, Qiu, Xuan“…Actinobacteria were predominant in weathered rock, whereas Proteobacteria dominated the sediment. …”
Publicado 2021
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4187por Voon, Yap Chee, Omar, Intan Sofia, Wu, Ming-Heng, Said, Nur Akmarina B.M., Chung, Ivy“…The ROCK1 inhibitor Y-27632 attenuated the motility of tumor cells in ECC-1 and CAF co-cultures. …”
Publicado 2022
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4188por Liao, Wei“…Proper sand production in this stage can make the rock permeability and the gas production grow to a certain extent. …”
Publicado 2021
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4189por Duchnowska, Magdalena, Strzałkowski, Paweł, Bakalarz, Alicja, Kaźmierczak, Urszula, Köken, Ekin, Karwowski, Piotr, Wolny, Michał, Stępień, Tomasz“…The samples are differentiated regarding both lithological variances, mineral composition as well as the host rock’s tuff content. The rock comminution processes were conducted using two types of crushers, namely the laboratory-scale jaw and cone crushers. …”
Publicado 2023
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4190“…Furthermore, we show that ROCK hyperactivity occurs in sporadic and familial human CCM endothelium as judged by increased phosphorylation of myosin light chain. …”
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4191“…For rock wool, IARC (2002) concluded that the epidemiological studies did not provide evidence of carcinogenicity. …”
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4192por Wang, Cunjin, Song, Siyuan, Zhang, Yang, Ge, Yali, Fang, Xiangzhi, Huang, Tianfeng, Du, Jin, Gao, Ju“…The spinal cord of LPS-treated mice showed increased active GTP-bound RhoA and upregulation of ROCK2 and c-fos compared to the normal saline group. …”
Publicado 2015
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4193por Qin, Xiang, Hannezo, Edouard, Mangeat, Thomas, Liu, Chang, Majumder, Pralay, Liu, Jiaying, Choesmel-Cadamuro, Valerie, McDonald, Jocelyn A., Liu, Yiyao, Yi, Bin, Wang, Xiaobo“…Here, we show that basal myosin II oscillation in Drosophila ovarian epithelium is not controlled by actomyosin cortical tension, but instead relies on a biochemical oscillator involving ROCK and myosin phosphatase. Key to this oscillation is a diffusive ROCK flow, linking junctional Rho1 to medial actomyosin cortex, and dynamically maintained by a self-activation loop reliant on ROCK kinase activity. …”
Publicado 2018
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4194por Tang, Qian, Low, Gabriel Weijie, Lim, Jia Ying, Gwee, Chyi Yin, Rheindt, Frank E.“…The rock pigeon, Columba livia, is a cosmopolitan human commensal, domesticated thousands of years ago. …”
Publicado 2018
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4195por Reid, Mhairi, Bordy, Emese M, Taylor, Wendy L, le Roux, Stephan G, du Plessis, Anton“…BACKGROUND: Taphonomic and palaeoecologic studies of obrution beds often employ conventional methods of investigation such as physical removal and extraction of fossils from their host rock (matrix) by mechanical preparation. This often-destructive method is not suitable for studying mold fossils, which are voids left in host rocks due to dissolution of the original organism in post-depositional processes. …”
Publicado 2018
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4196por Luisier, Cindy, Baumgartner, Lukas, Schmalholz, Stefan M., Siron, Guillaume, Vennemann, Torsten“…Pressure–temperature–time paths obtained from minerals in metamorphic rocks allow the reconstruction of the geodynamic evolution of mountain ranges under the assumption that rock pressure is lithostatic. …”
Publicado 2019
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4197“…Coal gangue, rock and soil stripping materials, and fly ash can thus be used as substitutes for topsoil. …”
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4198“…The experiment on the influence of the nanoemulsion on the spontaneous imbibition of reservoir rocks shows that when the gas permeability of reservoir rocks is K(g) < 5.0 mD, adding a nanofluid in the working fluid to change the wettability of reservoir rocks can effectively reduce the imbibition and retention of external fluids in reservoir rocks, thus reducing the “water locking damage”. …”
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4199por Álvarez-Salamero, Candelas, Castillo-González, Raquel, Pastor-Fernández, Gloria, Mariblanca, Isabel R., Pino, Jesús, Cibrian, Danay, Navarro, María N.“…IL-23-induced RLC phosphorylation required Janus kinase 2 (JAK2) and Rho-associated protein kinase (ROCK) catalytic activity, and further study of the IL-23/ROCK connection revealed an unexpected role of IL-23 in the migration of Tγδ17 and Th17 cells through ROCK activation. …”
Publicado 2020
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4200“…The mapping results show that the engineering rock group of a high-susceptibility unit usually develops in soft rock or soft–hard interphase rock groups, and the slope is between 15°–30°. …”
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