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  1. 4281
    “…Mechanically, HDAC3 promoted the transcription of Rho-associated protein kinase 1 (ROCK1) in AT2. In the context of LPS stimulation, the upregulated ROCK1 elicited by HDAC3 could be phosphorylated by Rho-associated (RhoA), thus disturbing MQC and triggering ALI. …”
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    HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control
  2. 4282
    por Wu, Pengfei, Zhao, Jihe, Jin, Jiaxu
    Publicado 2023
    “…Similar simulation experiments were conducted to study the movement and deformation of overburden rock and the displacement and stress distribution law of overburden rock in the coal mine under different filling rates and filling steps conditions. …”
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    Similar simulation of overburden movement characteristics under paste filling mining conditions
  3. 4283
    “…An adsorption film formed on rocks can effectively postpone the contact between the hydrogen ion and rock, which is of great significance in decreasing the rate of an acid–rock reaction. …”
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    Investigation of the Nonionic Acidizing Retarder AAO for Reservoir Stimulation
  4. 4284
    por Wang, Jun, Wang, Hanke, Dang, Yalong
    Publicado 2023
    “…Ripasudil (0.4%), another ROCK inhibitor, also lowers IOP; however, conjunctival hyperemia is the most common adverse drug reaction. …”
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    Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy
  5. 4285
    por Lemm, Jeffrey M., Martin, Meghan S.
    Publicado 2023
    “…Conservation breeding of West Indian rock iguanas (Cyclura) has met with limited success historically. …”
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    Social opportunities and mate preference improve breeding success in Caribbean iguanas
  6. 4286
    “…Moesin activation by estradiol depends on the interaction of ERα with the G protein Gα(13), which results in the recruitment of the small GTPase RhoA and in the subsequent activation of its downstream effector Rho-associated kinase-2 (ROCK-2). ROCK-2 is responsible for moesin phosphorylation. …”
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    Extra-Nuclear Signalling of Estrogen Receptor to Breast Cancer Cytoskeletal Remodelling, Migration and Invasion
  7. 4287
    “…We have previously shown that the RhoA/Rho kinase (ROCK) pathway is misregulated in cellular and animal SMA models, and that inhibition of ROCK with the chemical Y-27632 significantly increased the lifespan of a mouse model of SMA. …”
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    Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy
  8. 4288
    “…In the present study, using fasudil which is a specific inhibitor of ROCK, we aimed to investigate whether improved SERCA expression and activity accounts for reduced ER stress by ROCK inhibition, specifically whether PI3K/Akt and JAK2/STAT3 pathways are differentially involved in modulating SERCA activity to reduce ER stress and hence I/R injury. …”
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    Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways
  9. 4289
    “…Fitness of the Rock-kdr was then evaluated in comparison with Rockefeller. …”
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    Assessing the Effects of Aedes aegypti kdr Mutations on Pyrethroid Resistance and Its Fitness Cost
  10. 4290
    “…Pretreatment with Y-237642 (a ROCK inhibitor) prevented p4N1-induced myosin activation and fenestrae decrease. …”
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    The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells
  11. 4291
    “…In addition, downstream of the NGF receptor TrkA, increased levels of the signaling proteins ROCK2 and phosphorylated Raf-1 were found in stromal cells and a tendency towards increased levels of ROCK2 in trophoblasts and endothelial cells in SSRI-treated women when compared to healthy controls. …”
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    The Effect of Antenatal Depression and Selective Serotonin Reuptake Inhibitor Treatment on Nerve Growth Factor Signaling in Human Placenta
  12. 4292
    “…The failure mode for edifice host rock has attendant implications for the structural stability of the edifice and the efficiency of the sidewall outgassing of the volcanic conduit. …”
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    Fracture and compaction of andesite in a volcanic edifice
  13. 4293
    “…Comparative analysis revealed several candidate mutations for GC peritoneal carcinomatosis: recurrent mutations in COL4A6, INTS2, and PTPN13; mutations in druggable genes including TEP1, PRKCD, BRAF, ERBB4, PIK3CA, HDAC9, FYN, FASN, BIRC2, FLT3, ROCK1, CD22, and PIK3C2B; and mutations in metastasis-associated genes including TNFSF12, L1CAM, DIAPH3, ROCK1, TGFBR1, MYO9B, NR4A1, and RHOA. …”
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    Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites
  14. 4294
    “…To investigate the protective mechanism of picroside II on the BBB, the levels of ROCK, MLCK, MMP-2 and claudin-5 were tested. RESULTS: A higher neurological score, bigger cortex infarction, more damaged neuron structure and injured BBB, increased content of ROS and activity of NADPH oxidase, higher protein levels of Nox2, Rac-1, ROCK, MLCK and MMP-2 and lower levels of claudin-5 were observed in the model group. …”
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    Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury
  15. 4295
    “…Finally, we affirmed that TUG1 affected ROCK1 expression and ROCK1‐mediated migration/invasion by working as a competitive endogenous RNA (ceRNA) via miR‐335‐5p. …”
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    Long non‐coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR‐335‐5p in osteosarcoma cells
  16. 4296
    “…They often occur in cavities within the rock, and fit so tightly, it is natural to assume they sculpted these “pits.” …”
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    Bioerosion by pit-forming, temperate-reef sea urchins: History, rates and broader implications
  17. 4297
    “…We recently demonstrated that application of exogenous ET‐1 increased NHE activity in murine PASMCs via a mechanism requiring Rho kinase (ROCK). However, whether ROCK and/or increased NHE activity mediate ET‐1‐induced migration and proliferation in PASMCs remains unknown. …”
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    Rho kinase and Na(+)/H(+) exchanger mediate endothelin‐1‐induced pulmonary arterial smooth muscle cell proliferation and migration
  18. 4298
    “…Additionally, inhibition of RhoA/ROCK blocked the progressive increase in membrane permeability, and the remaining response was explained by the other non-selective channels. …”
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    Angiotensin II-Induced Mesangial Cell Damage Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels
  19. 4299
    “…We found an age‐dependent increase in ROCK2 mRNA expression, and in basal MT. The specific ROCK2 inhibitor KD025 robustly inhibited MT in SMAs in all mice with an age‐dependent variation in KD025 sensitivity. …”
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    Role of age, Rho‐kinase 2 expression, and G protein‐mediated signaling in the myogenic response in mouse small mesenteric arteries
  20. 4300
    por Yuan, Jie, Zhang, Fan, You, Meng, Yang, Qin
    Publicado 2018
    “…Furthermore, ROCK–mTOR inhibitors could reprogram breast cancer cells to another terminal lineage-adipogenic cells. …”
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    RETRACTED ARTICLE: Identification of protein kinase inhibitors to reprogram breast cancer cells
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