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  1. 4401
    “…The pan Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor fasudil acts as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 years in Japan and China. …”
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    Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer’s Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil
  2. 4402
    “…Tight unconventional rocks are characterized by the presence of laminations, preferentially oriented cracks, and an interconnected network of compliant minerals. …”
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    A novel anisotropy template for an improved interpretation of elastic anisotropy data
  3. 4403
    “…Because Shrm2 directly interacts with Rock, and Shrm2 knockdown results in the loss of Rock and activated myosin II from sites of cell–cell adhesion, we conclude that Shrm2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis.…”
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    Shroom2 regulates contractility to control endothelial morphogenesis
  4. 4404
    “…We investigated the effect of the Rho/Rho-associated protein kinase (ROCK) inhibitor fasudil on cardiac mitochondria from rats in which diabetes was induced by a combination of streptozotocin (STZ) and a sustained high-fat diet. …”
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    The Protective Effect of Fasudil on the Structure and Function of Cardiac Mitochondria from Rats with Type 2 Diabetes Induced by Streptozotocin with a High-Fat Diet Is Mediated by the Attenuation of Oxidative Stress
  5. 4405
    “…Several strategies have been used to target angiogenesis; however, it is becoming increasingly apparent that current anti-angiogenic therapies frequently achieve only modest effects in clinical settings. The RhoA/Rho kinase (ROCK) pathway plays a crucial role in the process of angiogenesis in PCa, and studies have demonstrated that ROCK inhibitors decrease VEGF-induced angiogenesis and tumor cell growth. …”
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    The role of the RhoA/Rho kinase pathway in angiogenesis and its potential value in prostate cancer (Review)
  6. 4406
    “…In this study, tassels of Cave-in-Rock (upland) and Alamo (lowland) were removed at or near tassel emergence to explore its effects on biomass production and quality. …”
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    Tassel Removal Positively Affects Biomass Production Coupled with Significantly Increasing Stem Digestibility in Switchgrass
  7. 4407
    por Chang, Ching-Wei, Kumar, Sanjay
    Publicado 2015
    “…SF retraction dynamics associated with MIIA and MIIB suppression qualitatively phenocopy our earlier measurements in the setting of Rho kinase (ROCK) and myosin light chain kinase (MLCK) inhibition, respectively. …”
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    Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics
  8. 4408
    “…OBJECTIVE: Exposure to radon is associated with approximately 10% of U.S. lung cancer cases. Geologic rock units have varying concentrations of uranium, producing fluctuating amounts of radon. …”
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    Radon potential, geologic formations, and lung cancer risk
  9. 4409
    “…These results reveal that MURC has a function in the development of PH through modulating Rho/ROCK signalling.…”
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    MURC deficiency in smooth muscle attenuates pulmonary hypertension
  10. 4410
    “…Yet the fluid flow in rough fractures of underground rock is poorly understood. Here we present a numerical method and experimental measurements to probe the effect of fracture roughness on the properties of fluid flow in fractured rock. …”
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    Fractal model and Lattice Boltzmann Method for Characterization of Non-Darcy Flow in Rough Fractures
  11. 4411
    “…Of note, expressions of RhoA, ROCK1, ROCK2, caspase-3, caspase-9, bax and the phosphorylation of NF-κBp65 were increased accompanying the smoke exposure-induced cognitive impairments, which were significantly inhibited by fasudil treatment as indicted in western blot and immunohistochemistry analysis. …”
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    Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure
  12. 4412
    “…Ultramafic rock weathering produces a residual that is enriched in Ni and also silica. …”
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    Peridotite weathering is the missing ingredient of Earth’s continental crust composition
  13. 4413
    “…In anaplastic thyroid cancer C643 cells, sphingosine 1-phosphate (S1P) attenuates migration by activating the S1P(2) receptor and the Rho-ROCK pathway. In the present study, we show that stimulating C643 cells with S1P decreases the expression, secretion and activity of matrix metalloproteinase-2 (MMP2), and to a lesser extent MMP9. …”
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    Sphingosine 1-phosphate attenuates MMP2 and MMP9 in human anaplastic thyroid cancer C643 cells: Importance of S1P(2)
  14. 4414
    “…In this paper, three dominant types of borehole-wall images on coal-rock mass structure, namely, border images, fracture images and intact rock mass images are mainly studied. …”
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    A two-stage classification method for borehole-wall images with support vector machine
  15. 4415
    “…ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. …”
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    Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment
  16. 4416
    “…Groundwater chemistry is mainly of rock dominance. Correlation analysis and graphical relationships between ions reveal that ion exchange and rock weathering such as the dissolution of halite, albite, and dissolution of carbonate minerals are important rock–water interactions, governing the evolution of groundwater chemistry. …”
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    Hydrogeochemical Characterization and Suitability Assessment of Groundwater: A Case Study in Central Sindh, Pakistan
  17. 4417
    “…Both the hydrophobic capillary force and adhesion work contribute to increasing water injection; and in particular, there is a critical point in the pressure-permeability curves for the rock cores with different wettabilities. Only above the critical point, the hydrophobic rock core exhibits a higher effective water permeability than that of the hydrophilic one, which is imperative for drag reduction. …”
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    Hydrophobic Silica with Potential for Water-Injection Augmentation of a Low-Permeability Reservoir: Drag Reduction and Self-Cleaning Ability in Relation to Interfacial Interactions
  18. 4418
    por Selvadurai, A. P. S.
    Publicado 2019
    “…The Cobourg limestone is a heterogeneous argillaceous rock consisting of lighter nodular regions of calcite and dolomite, interspersed with darker regions composed of calcite, dolomite, quartz and a clay fraction. …”
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    A Multi-Phasic Perspective of the Intact Permeability of the Heterogeneous Argillaceous Cobourg Limestone
  19. 4419
    “…An understanding of the enrichment mechanisms of cadmium (Cd) and arsenic (As) in the process of rock weathering and soil formation is essential to develop agriculture according to local conditions. …”
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    Enrichments of Cadmium and Arsenic and Their Effects on the Karst Forest Area
  20. 4420
    “…The Lost City hydrothermal vent field, fueled by just rock and water, provides an analog for not only primitive ecosystems but also potential extraterrestrial rock-powered ecosystems. …”
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    Genomic Evidence for Formate Metabolism by Chloroflexi as the Key to Unlocking Deep Carbon in Lost City Microbial Ecosystems
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