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  1. 4781
    “…In vitro validation demonstrated redundancy of several RhoGEFs upstream of RhoA and confirmed ROCK as a druggable target downstream of RhoA. The anti-metastatic effects of two ROCK inhibitors were demonstrated through in vivo melanoma metastasis tracking and inhibitor effects also confirmed ex vivo by digital pathology. …”
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    A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
  2. 4782
    “…Similar to salidroside, ROCK-selective inhibitors Y26732, and Fasudil protected HUVECs from IH-induced ROS overproduction and endothelial barrier disruption. …”
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    Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway
  3. 4783
    “…CONCLUSIONS: ITRI-E-(S)4046 is a novel type of highly specific ROCK1/2 and MYLK4 inhibitor that can reduce IOP in normotensive and hypertensive animal models. …”
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    The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models
  4. 4784
    “…Cold exposure increased RhoA, Rock1, p-MLC-2, ET-1, iNOS, and p-PKC expression and decreased eNOS expression. …”
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    Reactive Oxygen Species Are Essential for Vasoconstriction upon Cold Exposure
  5. 4785
    “…Gα(q/11)-coupled and Gα(12/13)-RhoA-ROCK signaling appear to mediate these contractions simultaneously. …”
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    Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle
  6. 4786
    “…Western blot was performed to detect the protein expression of FOXO1 in tissues and FOXO1, RhoA, p-RhoA, ROCK-2, and p-ROCK-2 in cells. RESULTS: In tissues, serum, and NSCLC cell line A549 of the NSCLC patients, the expression of FOXO1 was notably lower, and the miR-31-3p expression was significantly higher. …”
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    MiroRNA-31-3p Promotes the Invasion and Metastasis of Non-Small-Cell Lung Cancer Cells by Targeting Forkhead Box 1 (FOXO1)
  7. 4787
    “…The levels of MMP2, MMP7, MMP9, Rock1, RhoA and p53, p21, Bax protein in BMI1 overexpression group were significantly increased, while the levels of MMP2, MMP7, MMP9, Rock1, RhoA and p53, p21, Bax protein in BMI1 inhibitor group were significantly decreased. …”
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    Effects of BMI1 Gene on Regulating Apoptosis, Invasion, and Migration of HEC-1B Cells Induced by Ionizing Radiation
  8. 4788
    “…These findings suggest the clinical potential of pharmacological inhibition of ROCK1/2 in combination with IFN-therapy for the treatment of MPNs.…”
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    Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms
  9. 4789
    “…MiR-182-5p or miR-96-5p agomir treatment significantly rescued HCC cell migration and invasion in vitro that were repressed by RND3 overexpression, during which ROCK1 and ROCK2 inhibition were involved. MiR-182-5p or miR-96-5p agomir treatment also increased HCC cell proliferation and cisplatin resistance in vitro, which could be antagonized by RND3 overexpression or ROCK inhibition. …”
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    Retracted Article: MiR-182-5p and miR-96-5p increased hepatocellular carcinoma cell mobility, proliferation and cisplatin resistance partially by targeting RND3
  10. 4790
    “…Heat stress (43°C) increased phosphorylation of both ROCK and c-Jun with greater increases observed in the RBC2 line. …”
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    Temperature and Growth Selection Effects on Proliferation, Differentiation, and Adipogenic Potential of Turkey Myogenic Satellite Cells Through Frizzled-7-Mediated Wnt Planar Cell Polarity Pathway
  11. 4791
    “…The method allows scale inhibitors to adsorb on the internal rock surface to avoid settling down the scale precipitates. …”
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    Iron Sulfide Scale Inhibition in Carbonate Reservoirs
  12. 4792
    “…They are determined by impregnating rocks with ferrofluid and then measuring their magnetic anisotropy. …”
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    Ferrofluid Impregnation Efficiency and Its Spatial Variability in Natural and Synthetic Porous Media: Implications for Magnetic Pore Fabric Studies
  13. 4793
    “…Thermal loading is an important factor that could lead to the weakening and deterioration of rock materials. Understanding the thermal properties of rocks and their evolution under different high temperatures is important in the post-fire-hazard evaluation and cultural heritage conservation. …”
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    Mesoscopic and macroscopic investigation of a dolomitic marble subjected to thermal damage
  14. 4794
    “…The ceRNA network includes hsa_circ_0002190/hsa_circ_0046843/lnc-CARMN -miR-23a-3p - ROCK2 and hsa_circ_0001326/hsa_circ_0007733/lnc-AC107959/lnc-TPM1-AS - miR-205-5p - ROCK2/PPP1R12B/VEGFD. …”
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    Construction of a focal adhesion signaling pathway-related ceRNA network in pelvic organ prolapse by transcriptome analysis
  15. 4795
    por Wei, Chun-Sheng, Zhao, Zi-Fu
    Publicado 2022
    “…It has been well known that the influxing meteoric water can hydrothermally lower oxygen and hydrogen isotopes of rocks and/or minerals during continental magmatic or metamorphic processes in certain appropriate cases. …”
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    Paradoxically lowered oxygen isotopes of hydrothermally altered minerals by an evolved magmatic water
  16. 4796
    “…According to whether the fractured rock blocks generated by the main roof are articulated and whether the upper coal seam has been mined and influenced on the lower coal seam, two roof structure mechanical models of the rock blocks generated by the thick main roof and two calculation methods of a given load on the rock blocks are proposed. …”
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    Theoretical research on reasonable shield support capacity in close-multiple coal seams with the coordinated mining: A case study of Qianjiaying coal mine
  17. 4797
    “…The Roofex is too “soft” or “smooth” to limit the movement of ejected rocks and restrain the large deformation, although it has an excellent deformation capacity. …”
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    Evaluation of the performance of yielding rockbolts during rockbursts using numerical modeling method
  18. 4798
    “…To analyse the influence of normal stress (σ(n)) and steel tube strength on an anchor cable with a C-shaped tube (ACC), we selected Q235 steel tubes and Q345 steel tubes as representative ACCs and carried out double shear tests of ACC-reinforced jointed rock masses. Based on the test results, the influence of the steel tube strength on the ACC axial force and shear force under different normal stresses, the characteristics of the shear force-shear displacement curve of the anchored flat structural plane (FSP) in the rock mass, and the ACC failure mode and contribution to the anchored concrete surface shear strength were studied. …”
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    Experimental study on the shear performance of an anchor cable with a C-shaped tube anchored flat structural plane
  19. 4799
    “…Due to the characteristics of serious coal-rock fragmentation, large roof deformation, and integration of top coal and side coal. …”
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    Supporting optimization of thick seam roadway with top coal based on orthogonal matrix analysis
  20. 4800
    por Karter, Elizabeth, 1966-
    Publicado 2013
    Tabla de Contenidos: “…-- Sliding into trouble -- Escaping to a trap -- Rock bottom -- Assessing reality -- Creating a therapeutic experience -- Ambivelence -- Understanding why -- Relapse prevention -- One woman's story -- Reflections on practice.…”
    Libro
    Women and problem gambling : therapeutic insights into understanding addiction and treatment
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