“…BACKGROUND: Constitutive activation of RhoA-dependent RhoA kinase (ROCK) signalling is known to promote cellular transformation and the ROCK inhibitor Y-27632 has the ability to suppress focus formation of RhoA transformed NIH3T3 cells. …”
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“…Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD. …”
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“…Archaeal community structure and potential functions within the deep, aphotic, oligotrophic, hot, igneous provinces of ∼65 Myr old basalt and its Archean granitic basement was explored through archaeal 16S rRNA gene amplicon sequencing from extracted environmental DNA of rocks. Rock core samples from three distinct horizons, basaltic (BS), transition (weathered granites) (TZ) and granitic (GR) showed limited organic carbon (4–48 mg/kg) and varied concentrations (<1.0–5000 mg/kg) of sulfate, nitrate, nitrite, iron and metal oxides. …”
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“…Additionally, mice were divided into five additional groups: i) Non-ventilated group; ii) non-ventilated + LPS group; iii) ventilated group; iv) ventilated + LPS group; and v) ventilated + LPS + Rho-associated coiled-coil forming protein kinase (ROCK)1 inhibitor group. ROCK1 inhibitor (10 mg/kg) was injected intraperitoneally 1 h prior to ventilation. …”
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“…We focused on vagrant forms (growing obligately unattached to substrates) within a clade of rock-dwelling, sexually reproducing species in the Rhizoplaca melanophthalma (Lecanoraceae, Ascomycota) species complex. …”
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“…Mechanistically, OGD/R activated Ras homolog family member A (RhoA)/Rho-associated coiled-coil-containing protein kinase (Rock)/phosphatase and tensin homologue deleted on chromosome 10 (PTEN) signaling, whereas CTRP6 overexpression restored the expression of RhoA, Rock, PTEN, phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt). …”
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“…Emodin could regulate Notch1 and RhoA/ROCK pathways by regulating the miR-218a-5p expression in the intestine. …”
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“…Fracture geometry is almost controlled by the injection fluid’s viscosity, in case of constant injection rate; while rock properties have insignificant effect on the fracture width compares to fracturing fluid’s effect. …”
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“…The expression of HIF-1α, ET-1, Ang-II, Rock-1, and MMP-2 in the anti-HIF1α group was also significantly lower than that in the LS group. …”
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“…However, even when correcting for jaw length and jaw out-lever length, rock-dwelling species bite harder than ground-dwelling species. …”
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“…Compressive strength was measured from the scratch test, confirming that filter cake formation caused added strength to the rock that impacts the rock breakdown pressure. The average compressive strength of the original specimen was 44.5 MPa that increased to 73.5 MPa after the formation of filter cake. …”
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“…Meteoric groundwater feeding boreholes demonstrated variable recharge rates likely due to a complex and undefined fracture system within the host rock. 16S rRNA gene analysis determined that unique microbial communities occupy the four boreholes examined. …”
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“…Noticeable reduction was observed in dynamic rock stiffness and BI with the increase in acid concentrations. …”
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“…Based on the Kuangou Coal Mine as the background, using microseismic monitoring instruments and pressure sensor monitoring systems, the rock pressure appearance and microseismic energy characteristics accompanying the evolution of the overburden strata structure in the mining of solid coal and the lower working face of the gob are analyzed. …”
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“…[Image: see text] The size ranges of ore pillars play important roles in preventing the occurrences of rock burst phenomena. Due to the lack of research on the relationship between crack evolution behaviors and bursting liability of rocks with different sizes, uniaxial compression tests on sandstone with different height-to-diameter ratios (H/D) were conducted. …”
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“…Shale weathering is of particular interest because shale, the most abundant rock type exposed on continents, stores much of the ancient organic carbon (OC(petro)) buried in rocks. …”
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“…Inoculation with PSB and fertilization with rock phosphate (RP) increased soil labile P and acid phosphomonoesterase activity. …”
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“…Altogether, our work describes the unique dynamics of Langerhans cells and involvement of the ROCK pathway in immune cell responses to damage of varying magnitude.…”
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“…The mechanical behavior of soils as construction materials is linked to the nature of the parent rock and its environment of formation. Four different types of rock have been noted: trachybasalt, orthogneiss, anatexite, and biotite-hornblende granitoid. …”
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