“…Lastly, we found prominent nuclear activity of GLI2, YAP and β-catenin, concomitant with increased ROCK signalling and stromal fibrosis in human BCC. …”
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“…Photosynthetic microbial communities under translucent rocks (hypolithic) are found in many arid regions. …”
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“…GLGZD plays a vital role in promoting axonal remodeling and functional remodeling, which may be related to regulation of the expression of Nogo-A and its receptor NgR1, near the injured axons, inhibition of the Rho-ROCK pathway, and reduction of CRMP2 phosphorylation.…”
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“…We recently employed a synthetic lethal drug screen plus a combinatorial strategy using a panel of clinical agents and discovered that KRAS-mutant cancers were fragile to the combined inhibition of polo-like kinase 1 (Plk1) and RhoA/Rho kinase (ROCK). The combined regimen of BI-2536 (a Plk1 inhibitor) and fasudil (a ROCK inhibitor) promoted a significant inhibition of patient-derived lung cancer xenografts and prolonged the survival of LSL-KRAS(G12D) mice. …”
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“…As a consequence, great effort has been expended to link rock magnetic behavior to paleointensity results, but with little quantitative success. …”
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“…Therefore, metformin’s dual effect in hyperglycemia-chemical hypoxia is mediated by direct effect on VEGFR1/R2 leading to activation of cell migration through MMP16 and ROCK1 upregulation, and inhibition of apoptosis by increase in phospho-ERK1/2 and FABP4, components of VEGF signaling cascades.…”
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“…Rates in wet martian sediment and microfractured rock are comparable with rates in terrestrial environments that harbor low concentrations of microbial life (e.g., subseafloor basalt). …”
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“…This activated intracellular signaling pathways to increase RhoA activity and ROCK phosphorylation, ultimately inhibiting neurite outgrowth. …”
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“…Here we report a draft genome of the Sydney Rock Oyster, Saccostrea glomerata, an iconic and commercially important species of edible oyster in Australia known for its enhanced resilience to harsh environmental conditions. …”
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“…Finally, RHOA and the Rho activated protein kinases ROCK1 and ROCK2 positively regulated tube formation independently of ERK, while RHOC seemed to inhibit the process. …”
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“…Furthermore, ET-1/ETAR promoted RhoA/ROCK pathway in mesangial cells, and accelerated mesangial cell proliferation and ECM accumulation. …”
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“…Detail information on the low-temperature thermal histories of rocks, below∼120 °C for tracks in apatite and below∼350 °C for zircon, can be provided by Fission-track (FT) analysis. …”
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“…Western blot analysis revealed that CPT treatment significantly reversed the protein expression levels of Rho, ROCK1, ROCK2, p-P65, p-IκBα, p-IKKα, and p-IKKβ in liver samples obtained from db/db mice. …”
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“…Restricted δ(2)H variability along with variable and high δ(18)O values suggest water–rock interactions at temperatures exceeding 95 °C.…”
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“…Collectively, our findings demonstrate that, through a Rho-ROCK/miR-145/KLF4 pathway, the elongated cell shape serves as a decisive geometric cue to direct MSC differentiation into functional SMCs.…”
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“…Maximum brackets are much harder to establish, largely because it is difficult to establish definitive evidence that the absence of a taxon in the fossil record is real and not just due to the incompleteness of the fossil and rock records. Five primary methods have been developed to estimate maximum age brackets, each of which is discussed. …”
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“…In order to study the effect of water-rock interactions on shear strength characteristics, we performed shearing tests under varying hydrochemical environments. …”
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“…Nonlinear exponential trend model is linearized into the linear model, then linearized model parameters are regarded as the state vector containing the dynamic noise to erect Kalman filter model based on exponential trend model to predict the deformation of the rock landslide. Deformation observation values of the landslide are regarded as a time series to erect AR(1) model, then model parameters of AR(1) model are regarded as the state vector containing the dynamic noise to erect Kalman filter model based on AR(1) model to predict the deformation of the rock landslide. …”
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“…To design secure storage, we need to understand how the fluids are configured in the microscopic pore spaces of the reservoir rock. We use high-resolution X-ray imaging to study the flow of oil, water and CO(2) in an oil-wet rock at subsurface conditions of high temperature and pressure. …”
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“…First, the procedures of retaining roadway, roof-cutting parameters and the damage ranges of roadway surrounding rock induced by roof cutting with chain arm were analysed. …”
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