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5421por Kino, Tomoyuki, Tomori, Toshiki, Abutarboush, Rania, Castri, Paola, Chen, Ye, Lenz, Frederick A., McCarron, Richard M., Spatz, Maria“…The findings also showed the involvement of Rho/Rock and PI3/Akt/NO pathways in the ARA-S-induced phosphorylation of kinases and actin reorganization in HBEC. …”
Publicado 2016
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5422“…Here, we report the results of a detailed magnetostratigraphic and rock magnetic study of four hydrogenetic Fe-Mn crusts from the Pacific Ocean (PO-01), South China Sea (SCS-01, SCS-02) and Indian Ocean (IO-01). …”
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5423“…At day 3 after infarction, post‐infarction was associated with increased RhoA/ROCK activation, which can be inhibited by administering nicorandil. …”
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5424Particulate matter disrupts human lung endothelial cell barrier integrity via Rho-dependent pathwayspor Wang, Ting, Shimizu, Yuka, Wu, Xiaomin, Kelly, Gabriel T., Xu, Xiaoyan, Wang, Lichun, Qian, Zhongqing, Chen, Yin, Garcia, Joe G.N.“…This event is attenuated by NAC or knockdown of RhoA (siRNA). Consistent with ROCK activation, PM induced phosphorylation of myosin light chain phosphatase (MYPT) at Thr850, a post-translational modification known to inhibit phosphatase activity. …”
Publicado 2017
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5425por Kao, Ying-Hsien, Chen, Po-Han, Sun, Cheuk-Kwan, Chang, Yo-Chen, Lin, Yu-Chun, Tsai, Ming-Shian, Lee, Po-Huang, Cheng, Cheng-I“…Signal kinetic profiling study indicated that cyclic mechanical stretch induced signaling activity in RhoA/ROCK and PI3K/Akt cascades. Kinase inhibition study further showed that blockade of PI3K activity suppressed the stretch-induced tumor necrosis factor-α (TNF-α), whereas RhoA/ROCK inhibition significantly blunted the interleukin-6 (IL-6) production and HDGF overexpression. …”
Publicado 2018
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5426por Fujiwara, Sachiko, Matsui, Tsubasa S., Ohashi, Kazumasa, Deguchi, Shinji, Mizuno, Kensaku“…Similarly, knockdown of K18 or treatment with Y-27632, a specific inhibitor of Rho-associated kinase (ROCK), suppressed HD formation. As Solo knockdown or Y-27632 treatment is known to disorganize K8/K18 filaments, these results suggest that Solo is involved in HD formation by regulating K8/K18 filament organization via the RhoA-ROCK signaling pathway. …”
Publicado 2018
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5427“…This exploratory study investigates the groove effect of 248 reconstructed drum patterns from different popular music styles (pop, rock, funk, heavy metal, rock’n’roll, hip hop, soul, R&B). …”
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5428por Kugelmann, Daniela, Rotkopf, Lukas Thomas, Radeva, Mariya Yosifova, Garcia-Ponce, Alexander, Walter, Elias, Waschke, Jens“…Ca(2+) chelation by BAPTA-AM and ROCK1 inhibition by Y27632 abolished both increase of tension along AJs as well as barrier dysfunction. …”
Publicado 2018
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5429por McDermott, C. I., Fraser-Harris, A., Sauter, M., Couples, G. D., Edlmann, K., Kolditz, O., Lightbody, A., Somerville, J., Wang, W.“…Use of the subsurface for energy resources (enhanced geothermal systems, conventional and unconventional hydrocarbons), or for storage of waste (CO(2), radioactive), requires the prediction of how fluids and the fractured porous rock mass interact. The GREAT cell (Geo-Reservoir Experimental Analogue Technology) is designed to recreate subsurface conditions in the laboratory to a depth of 3.5 km on 200 mm diameter rock samples containing fracture networks, thereby enabling these predictions to be validated. …”
Publicado 2018
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5430“…The results of principal component analysis of the calcaneus and astragalus support this observation and place T. robustus in-between Rattus and ground/rock squirrel morphospace, and T. wilsoni closer to euarchontans, Tupaia and Purgatorius. …”
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5431“…By providing the first comprehensive maps of nonapeptide receptors in European starlings, house sparrows, and rock doves, our work supports the future use of these species as avian models for neuroecological studies of collective behaviors in wild birds.…”
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5432“…The basement reservoir rock is mainly composed of granite, quartz-feldspar, weathered silica, and mica minerals. …”
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5433por Phetcharat, Thanachai, Dawkrajai, Pinan, Chitov, Thararat, Wongpornchai, Pisanu, Saenton, Schradh, Mhuantong, Wuttichai, Kanokratana, Pattanop, Champreda, Verawat, Bovonsombut, Sakunnee“…Analysis of correlations between physiochemical properties of the reservoir and bacterial genera, using spearman’s correlation analysis, suggested that some of the reservoir’s properties, especially of the well and the rock, could influence some bacterial genera. To our knowledge, this is the first demonstration of the effect of inorganic nutrients on alteration of bacterial communities attached to reservoir’s rock, and how the bacterial, physical, and chemical properties of a reservoir were co-analysed to serve as a basis for designing a MEOR process.…”
Publicado 2018
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5434“…Using quantum-mechanical calculations of second- and third-order elastic constants for YN and ScN with the rock-salt (B1) structure, we predict that these materials change the fundamental type of their elastic anisotropy by rather moderate hydrostatic pressures of a few GPa. …”
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5435“…The aim of the present study is to identify genetic diversity of six brown layer pure chicken lines (Rhode Island Red [RIRI, RIRII], Barred Rock [BARI, BARII], Columbian Rock [COL], and line 54 [L-54]) with microsatellite markers. …”
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5436por Rangel, Laura, Bernabé-Rubio, Miguel, Fernández-Barrera, Jaime, Casares-Arias, Javier, Millán, Jaime, Alonso, Miguel A., Correas, Isabel“…Subsequent experiments showed that DIA1 and ROCK help regulate ciliary length. Since MDCK cells lack apical caveolae, our results imply that non-caveolar apical Cav1α is an important regulator of ciliary length, exerting its effect via RhoA and its effectors, ROCK and DIA1.…”
Publicado 2019
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5437por Xia, Yue-Feng, Chang, Jing, Yang, Jin-Feng, Ouyang, Wen, Pitt, Bruce, Billiar, Timothy, Zhang, Li-Ming“…Inhibition of ROCK1 by Y27632 and JNK by SP600125 attenuated MTV-induced lung injury and decreased the expression of proteins involved in non-canonical Wnt signaling, including WISP1. …”
Publicado 2019
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5438“…The generation of these gases increase rock cavity pressure and limit water ingress which delays the mobility of water soluble radionuclides. …”
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5439por Keslinka, Liliana Katarzyna, Wojczulanis-Jakubas, Katarzyna, Jakubas, Dariusz, Neubauer, Grzegorz“…Colony size was significantly associated with rock type (larger colonies in amphibolite and quartzite). …”
Publicado 2019
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5440por Minami, Yoshiro, Song, Young-seok, Ishibazawa, Akihiro, Omae, Tsuneaki, Ro-mase, Tomoko, ishiko, Satoshi, Yoshida, Akitoshi“…The current study aimed to address whether ripasudil, a Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor developed to treat glaucoma and ocular hypertension (OH), improves diabetic macular edema (DME) since it is known that ROCK upregulates vascular endothelial growth factor. …”
Publicado 2019
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