“…Here, we show that in human developing cardiomyocytes cell–cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA‐ROCK signaling to maintain an active MRTF/SRF transcriptional program essential for cardiomyocyte identity. …”
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“…We then give an overview of the current research status of Rho signaling in development, brain, cardiovascular system, immunity and cancer, and discuss the future directions of Rho signaling research, with emphasis on one Rho effector, ROCK*. *The Rho GTPase family. Rho family GTPases have now expanded to contain 20 members. …”
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“…We combined the shallow ice approximation and a glacial erosion rule to calculate ice surface and bed topography from prescribed glacier mass balance gradient and rock uplift rate. Our approach is inspired by the classic application of the stream power law for describing a fluvial steady state but with the striking difference that, in the glacial realm, glacier mass balance is added as an altitude‐dependent variable. …”
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“…A delicate micromodel with a complex pore geometry that represents a two-dimensional (2D) cross-section profile of a fractured rock in a natural oil or groundwater reservoir was developed for two-phase-flow experiments. …”
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“…Seismic data demonstrate the existence of a positive spatial correlation between gas discharges and extensional tectonic regimes and confirms that such processes would play a key role in creating pathways for the rising gases at micro- and macro-scales, increasing the rock permeability and connecting the deep crust to the earth surface.…”
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“…We identify that they act as effectors coupling RhoA and ROCK dependent signaling pathway to MLC2 phosphorylation and actin polymerization. …”
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“…These findings suggested that DL0805 is a novel vasorelaxant compound associated with inhibition of Rho/ROCK signaling pathway. The NO-cGMP pathway may be involved in the relaxation of DL0805 in endothelium-intact aorta. …”
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“…However, there is a pressing need for new algorithms to characterize oil/brine/rock system wettability, thus better predict and manage CO(2) geological storage and enhanced oil recovery in oil reservoirs. …”
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“…The ability of Trichoderma harzianum (strain OMG-08) as plant growth promoting fungus (PGPF), was tested on Zea mays plants grown in soil pots added with different inorganic (triple superphosphate and rock phosphate) and organic (cow and horse manure composts) P fertilizers. …”
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“…The objective of this study was to investigate the capacity of four endophytic Bacillus strains to solubilize iron phosphate (Fe-P), produce siderophores and indole-acetic acid (IAA) in vitro, and to evaluate their plant growth promotion ability in greenhouse conditions by inoculation into pearl millet cultivated in a P-deficient soils without P fertilization, with Araxá rock phosphate or soluble triple superphosphate. …”
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“…We found that the PDZ-mediated interaction of DLC3 and Scribble is essential for junctional DLC3 recruitment and its role as a local regulator of RhoA-ROCK signaling controlling adherens junction integrity and Scribble localization. …”
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“…This work demonstrates the formation of a network of permeable microfractures densely distributed throughout the entire rock body, representing a so-called cloud-fracture network. …”
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“…In this study Sydney rock oysters (S. glomerata) from six major sea ports of NSW, Australia were used as bioindicators to assess the distribution and levels of trace element accumulation in the ports. …”
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“…The reaction mechanism, examined by SEM technique and the reaction thermodynamic analysis suggested that the leaching of P(2)O(5) mainly resulted from the process of dissolution of dolomite (the main gangue mineral) in organic acid, consequently enriching the phosphate rock (the mineral of value). The effectiveness and impacts of different types of acid and reaction conditions were also studied. …”
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“…Built on the current research, the envisioned practical application of the proposed method may include clogging fractured rock, reducing seepage and prevent piping through dams, excavation dewatering, and forming barriers for remediating specific contaminants.…”
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“…Here, we use HTS of the internal transcribed spacer 2 (ITS2) to assess the taxonomic composition and diversity of a well-characterized, alpine rock lichen community that includes thalli symptomatically infected by lichenicolous fungi as well as asymptomatic thalli. …”
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“…Downregulation of one of the key GPCR effectors, endothelial differentiation GPCR5 (EDG5), impacted the maintenance of pluripotency, actin cytoskeleton organization, colony integrity, and focal adhesions in human embryonic stem cells, which were associated with the alteration in the RhoA‐ROCK‐Cofilin‐PAXILLIN‐actin signaling pathway. Similarly, downregulation of EDG5 during the initiation stage of somatic cell‐induced reprogramming resulted in alteration of cytoskeleton, loss of human‐induced pluripotent stem cell colony integrity, and a significant reduction in partially and fully reprogrammed cells as well as the number of alkaline phosphatase positive colonies at the end of the reprogramming process. …”
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“…Motile arrest after YAP/TAZ ablation was partially rescued by depletion of the YAP/TAZ-dependent myosin phosphatase regulator, NUAK2, or by inhibition of Rho-ROCK-myosin II. Together, these data establish a transcriptional feedback axis necessary to maintain a responsive cytoskeletal equilibrium and persistent migration.…”
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“…In mice harboring the Ser75Ala Src mutant, the activity of Rho-associated kinase (ROCK) in the striatum was significantly lower and Akt Ser473 phosphorylation was significantly higher than in wild-type mice. …”
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“…We demonstrate that host defense exerts strong phenotypic selection for crypsis in lice transferred to different colored rock pigeons (Columba livia). During four years of experimental evolution (∼60 generations), the lice evolved heritable differences in color. …”
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